| Project/Area Number |
17H06698
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| Research Category |
Grant-in-Aid for Research Activity Start-up
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| Allocation Type | Single-year Grants |
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| Research Field |
Orthodontics/Pediatric dentistry
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| Research Institution | Niigata University |
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Principal Investigator |
Kitami Kohei 新潟大学, 医歯学総合病院, 医員 (20804579)
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| Project Period (FY) |
2017-08-25 – 2019-03-31
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| Project Status |
Completed (Fiscal Year 2018)
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| Budget Amount *help |
¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
Fiscal Year 2018: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2017: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
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| Keywords | プライマリーシリア / 歯根膜 / 歯学 / 細胞・組織 / 矯正学的歯の移動 / 機械的刺激 / メカノセンサー |
|---|
| Outline of Final Research Achievements |
Periodontal ligament is extremely sensitive to mechanical stimuli, that enables orthodontic tooth movement. It remains elusive how mechanical stimuli are perceived and controlling tissue modification. In this study, we analyzed the distribution and the mechano-response of primary cilia, which is expected to function as a mechanoreceptor in periodontal ligament, in response to orthodontic tooth movement. Primary cilia was present in periodontal ligament, and preferential localization at the cementum-side of periodontal ligament was observed. The rate of cilia-positive cells was altered after orthodontic tooth movement.
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| Academic Significance and Societal Importance of the Research Achievements |
本研究は、機械的刺激受容体としての機能が期待されるプライマリーシリアの歯根膜組織中の局在特性に着目し、その作用機序を明らかにしようとするものである。プライマリーシリアによる機械的刺激に対する細胞応答メカニズムの解明は、あらゆる機械的刺激にさらされる生体機能の理解に向けたメカノバイオロジーの観点から、疾患の発生、治癒、再生を含めた今後の医歯薬学領域における研究の発展に大きく寄与することが期待される。
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