Research Project
Grant-in-Aid for Research Activity Start-up
We have developed protein-based synthetic organelles in living mammalian cells. Chemogenetic protein-releasing/trapping system into the synthetic organelle was developed. Protein activity was inactivated by trapping into the synthetic organelles due to the isolation from the substrates. Releasing of the proteins from the synthetic organelles resulted in the activation of the downstream signaling.
本研究により、さまざまな細胞内のタンパク質の機能を自由に制御することが可能になった。本技術は、基礎的な細胞生物学における研究ツールだけではなく、幹細胞の分化制御や細胞治療などへの応用が期待される。
All 2018
All Presentation (5 results)
