• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

The role of ER-derived signaling in axonal regeneration

Research Project

Project/Area Number 17H06891
Research Category

Grant-in-Aid for Research Activity Start-up

Allocation TypeSingle-year Grants
Research Field Neurochemistry/Neuropharmacology
Research InstitutionOsaka University (2018)
Hiroshima University (2017)

Principal Investigator

Ohtake Yosuke  大阪大学, 医学系研究科, 特任研究員(常勤) (40405915)

Project Period (FY) 2017-08-25 – 2019-03-31
Project Status Completed (Fiscal Year 2018)
Budget Amount *help
¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
Fiscal Year 2018: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2017: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Keywords小胞体 / 小胞体ストレス応答 / 神経再生 / 軸索損傷 / 神経軸索再生 / 脊髄損傷 / 小胞体ストレス / 末梢神経 / 軸索再生 / カルシウム / 脳・神経
Outline of Final Research Achievements

We revealed that peripheral axonal injury-dependent calcium release from the endoplasmic reticulum (ER) activated unfolded protein response (UPR) signaling, resulting in axonal regeneration after the injury. The local induction of UPR signaling leads to axonal regeneration through the regulation of axonal ER morphology and growth cone formation. In central nervous system, UPR activation by the genetic modulation enhances the growth capacity of mature neurons, although UPR signaling is decreased in response to spinal cord injury.

Academic Significance and Societal Importance of the Research Achievements

本研究では、これまで盲点であった小胞体シグナルを起点とする軸索再生制御と、細胞の機能維持・制御に重要な役割を担う小胞体ストレス応答系を結びつけたものであり、神経機能研究の分野に新たな概念を提示し、パラダイムシフトをもたらすことが期待される。さらに、小胞体機能が軸索再生の新規ターゲットとして確立されることにより、神経損傷だけでなく難治性の脳神経系疾患の革新的な治療法の開発に結び付くブレイクスルーとなることも期待され、国民の健康・福祉レベルの向上にもつながることから、社会的にも大きな意義を持つ研究である。

Report

(3 results)
  • 2018 Annual Research Report   Final Research Report ( PDF )
  • 2017 Annual Research Report
  • Research Products

    (5 results)

All 2019 2018 2017

All Journal Article (2 results) (of which Peer Reviewed: 2 results,  Open Access: 2 results) Presentation (3 results) (of which Int'l Joint Research: 1 results)

  • [Journal Article] Promoting Axon Regeneration in Adult CNS by Targeting Liver Kinase B12019

    • Author(s)
      Ohtake Yosuke、Sami Armin、Jiang Xinpei、Horiuchi Makoto、Slattery Kieran、Ma Lena、Smith George M.、Selzer Michael E.、Muramatsu Shin-ichi、Li Shuxin
    • Journal Title

      Molecular Therapy

      Volume: 27 Issue: 1 Pages: 102-117

    • DOI

      10.1016/j.ymthe.2018.10.019

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Axonal Activation of the Unfolded Protein Response Promotes Axonal Regeneration Following Peripheral Nerve Injury.2018

    • Author(s)
      Ohtake Y, Matsuhisa K, Kaneko M, Kanemoto S, Asada R, Imaizumi K, Saito A.
    • Journal Title

      Neuroscience

      Volume: 375 Pages: 34-48

    • DOI

      10.1016/j.neuroscience.2018.02.003

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Presentation] Signaling of the Unfolded Protein Response is Critical for Axon Regeneration after Nerve Injury2017

    • Author(s)
      Yosuke Ohtake, Atsushi Saito, Kazunori Imaizumi
    • Organizer
      日本神経化学学会大会
    • Related Report
      2017 Annual Research Report
  • [Presentation] Retrograde propagation of signaling regulated by UPR branches promotes peripheral nerve regeneration2017

    • Author(s)
      Yosuke Ohtake, Atsushi Saito, Koji Matsuhisa, Kazunori Imaizumi
    • Organizer
      Consortium of Biological Sciences 2017
    • Related Report
      2017 Annual Research Report
  • [Presentation] Axon Regeneration Promoted by Signaling of the Unfolded Protein Response in Peripheral Nerve Injury2017

    • Author(s)
      Yosuke Ohtake, Atsushi Saito, Kazunori Imaizumi
    • Organizer
      Neuroscience Annual Meeting
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research

URL: 

Published: 2017-08-25   Modified: 2020-03-30  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi