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The anticancer activity of catechol-typed lignan and neolignan in Jatropha seeds

Research Project

Project/Area Number 17H06914
Research Category

Grant-in-Aid for Research Activity Start-up

Allocation TypeSingle-year Grants
Research Field Wood science
Research InstitutionKagawa University

Principal Investigator

Katagi Ayako  香川大学, 医学部, 研究員 (30799458)

Research Collaborator Katayama Takeshi  
Suzuki Toshisada  
Tokuda Masaaki  
Kamitori Kazuyo  
Project Period (FY) 2017-08-25 – 2019-03-31
Project Status Completed (Fiscal Year 2018)
Budget Amount *help
¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
Fiscal Year 2018: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2017: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Keywordsジャトロファ / ネオリグナン / イソアメリカノールA / MCF-7 / MCF-10A / モノポーラースピンドル形成 / Hela / Protein kinase C beta / モノポーラスピンドル / エストロゲンレセプター / HeLa / Protein Kinase C beta / リグナン / カテコール / HuH-7 / ジャトロファ種子 / 抗癌活性
Outline of Final Research Achievements

The organic and water extracts of EtOAc and MEOH obtained from defatted jatropha seeds have been shown to inhibit the growth of hepatocytes and breast cancer cells. In addition, it became clear that isoamecanol A has different rates for inhibition on each cancer cell type. Isoamecanol A inhibited human breast cancer cell growth by 25.9 ± 6.14% (n = 4, p <0.05) than normal human breast cells. Furthermore, it was revealed that the inhibition of breast cancer cell growth is due to monopolar spindle formation, which leads to M stage of the cell cycle arrest.
The cell growth inhibition was induced in Hela cells due to G1 arrest by isoamecanol A treatment. In addition, it was suggested that the treatment increases the expression of protein kinase C beta, which suppresses the function of phorbol ester contained in seeds.

Academic Significance and Societal Importance of the Research Achievements

熱帯、亜熱帯を中心に育つジャトロファ種子は油が豊富であり、二酸化酸素の排出の少ない次世代燃料としての注目がある。また同時にジャトロファは古くから伝わる民間薬としての利用があるため、脱脂種子廃棄物の医療への利用、そして新たな抗癌剤の開発は経済的にも重要な試みである。

Report

(3 results)
  • 2018 Annual Research Report   Final Research Report ( PDF )
  • 2017 Annual Research Report
  • Research Products

    (12 results)

All 2019 2018 2017

All Journal Article (7 results) (of which Peer Reviewed: 7 results,  Open Access: 4 results) Presentation (5 results) (of which Int'l Joint Research: 2 results)

  • [Journal Article] Monopolar Spindle Induced by Isoamericanol A Suppresses Human Breast Cancer Cell (MCF-7) Growth2019

    • Author(s)
      Ayako Katagi , Li Sui, Kazuyo Kamitori, Toshisada Suzuki, Takeshi Katayama, Youyi Dong, Toshitaka Nakagawa, Koichi Yube, Akram Hossain, Fuminori Yamaguchi and Masaaki Tokuda
    • Journal Title

      Asian Journal of Cell Biology

      Volume: 14 (1) Issue: 1 Pages: 1-6

    • DOI

      10.3923/ajcb.2019.1.6

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Antioxidative catechol lignans/neolignans isolated from defatted seed of Tung tree2018

    • Author(s)
      Toshisada Suzuki、Tetsuaki Kato、Ayako Katagi、Takeshi Katayama
    • Journal Title

      Journal of the Forest Biomass Utilization Society

      Volume: 13 Pages: 47-51

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Inhibition of Atherosclerotic Plaque Development by Oral Administration of α-Glucosyl Hesperidin and Water-Dispersible Hesperetin in Apolipoprotein E Knockout Mice2018

    • Author(s)
      Sugasawa Noriko、Katagi Ayako、Kurobe Hirotsugu、Nakayama Taisuke、Nishio Chika、Takumi Hiroko、Higashiguchi Fumiharu、Aihara Ken-ichi、Shimabukuro Michio、Sata Masataka、Kitagawa Tetsuya
    • Journal Title

      Journal of the American College of Nutrition

      Volume: 38 Issue: 1 Pages: 15-22

    • DOI

      10.1080/07315724.2018.1468831

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Both Ser361 phosphorylation and the C-arrestin domain of thioredoxin interacting protein are important for cell cycle blockade at the G1/S checkpoint2018

    • Author(s)
      Kamitori Kazuyo、Yamaguchi Fuminori、Dong Youyi、Hossain Akram、Katagi Ayako、Noguchi Chisato、Hirata Yuko、Tsukamoto Ikuko、Hatano Naoya、Tokuda Masaaki
    • Journal Title

      FEBS Open Bio

      Volume: 8 Issue: 11 Pages: 1804-1819

    • DOI

      10.1002/2211-5463.12518

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Additive antitumour effect of D-allose in combination with cisplatin in non-small cell lung cancer cells2018

    • Author(s)
      Kanaji Nobuhiro、Kamitori Kazuyo、Hossain Akram、Noguchi Chisato、Katagi Ayako、Kadowaki Norimitsu、Tokuda Masaaki
    • Journal Title

      Oncology reports

      Volume: 39 Pages: 1292-1298

    • DOI

      10.3892/or.2018.6192

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] The role of calcitonin gene-related peptide in migraine prevention by botulinum toxin type A2018

    • Author(s)
      Juntima Pleumsamran、Apisate Pleumsamran、Supang Maneesri-le Grand、Siwaporn Chankrachang、Fuminori Yamaguchi、Kazuyo Kamitori、Akram Hossain、Chisato Noguchi、Li Sui、Ayako Katagi、Youyi Dong、Masaaki Tokuda
    • Journal Title

      Neurology Asia

      Volume: 23 Pages: 45-53

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] High Anticancer Properties of Defatted Jatropha Curcus Seed Residue and its Active Compound, Isoamericanol A.2017

    • Author(s)
      Ayako Katagia, Li Sui, Kazuyo Kamitori, Toshisada Suzuki, Takeshi Katayama, Akram Hossain, Chisato Noguchi, Youyi Dong, Fuminori Yamaguchi and Masaaki Tokuda
    • Journal Title

      Natural Product Communications

      Volume: 12 Pages: 1881-1884

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Presentation] High Anticancer Properties of Defatted Jatropha Curcas Seed Residue and its Active Compound, Isoamericanol A2018

    • Author(s)
      Ayako Katagi、Li Sui、Kazuyo Kamitori、Toshisada Suzuki、Takeshi Katayama、Youyi Dong、Toshitaka Nakagawa、Koichi Yube、Akram Hossain、Fuminori Yamaguchi、Masaaki Tokuda.
    • Organizer
      2018 SWST/JWRS International Convention
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Isoamericanol A from Jatropha curcas seed extract inhibits human breast cancer cell (MCF-7) proliferation by disrupting spindle formation at metaphase.2018

    • Author(s)
      Ayako Katagi、Li Sui、Kazuyo Kamitori、Suzuki T、Takashi Katayama、Akram Hossain、Chisato Noguchi、Youyi Dong、Fuminori Yamaguchi、Masaaki Tokuda.
    • Organizer
      The 68th Annual Meeting of the Japan Wood Research Society in Kyoto; Kyoto, Japan
    • Related Report
      2018 Annual Research Report
  • [Presentation] シナアブラギリ種子油のバイオディーゼル燃料利用と抗酸化活性成分の探索2018

    • Author(s)
      鈴木利貞、松山恵、加藤哲明、片木絢子、片山健至
    • Organizer
      樹木抽出成分討論会
    • Related Report
      2018 Annual Research Report
  • [Presentation] Antioxidative catechol lignans/neolignans isolated from defatted kernel of Tung tree.2018

    • Author(s)
      Toshisada Suzuki、Tetsuaki Kato、Ayako Katagi、Takeshi Katayama
    • Organizer
      The 61st International Convention of the Society of Wood Science and Technology and Japan Wood Research Society
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] イソアメリカノールAのMCF-7ヒト乳癌細胞に対する細胞増殖抑制効果のメカニズムはG2/M期アレストによる2017

    • Author(s)
      片木絢子、隋麗 、神鳥和代、鈴木利貞、片山健至、ホセインアクラム、野口知里、董有毅、山口文徳、徳田雅明
    • Organizer
      第67回日本木材学会大会 福岡
    • Related Report
      2017 Annual Research Report

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Published: 2017-08-25   Modified: 2020-03-30  

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