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The association between serum lipids and diabetic nephropathy in Japanese patients with type 2 diabetes mellitus.

Research Project

Project/Area Number 17H06918
Research Category

Grant-in-Aid for Research Activity Start-up

Allocation TypeSingle-year Grants
Research Field Epidemiology and preventive medicine
Research InstitutionEhime University

Principal Investigator

Hidenori Senba  愛媛大学, 医学部附属病院, 助教 (10807019)

Project Period (FY) 2017-08-25 – 2019-03-31
Project Status Completed (Fiscal Year 2018)
Budget Amount *help
¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
Fiscal Year 2018: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2017: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Keywords糖尿病性腎症 / 脂質 / Lipoprotein(a) / 脂質異常症 / 血清脂質 / 糖尿病 / 臨床
Outline of Final Research Achievements

The aim of dis study was to evaluate the association between serum lipids and diabetic nephropathy among Japanese patients with type 2 diabetes mellitus. In this study of 763 patients, both serum levels of triglyceride and lipoprotein(a) were positively independently associated with the prevalence of diabetic nephropathy. Serum levels of low-density cholesterol, high-density cholesterol, or remnant lipoprotein were not related to the prevalence of diabetic nephropathy. The results suggest that the serum triglyceride and serum lipoprotein(a) could be the risk of diabetic nephropathy.
To clarify whether these serum lipids are associated with the onset or progression of diabetic nephropathy, we are collecting further evidence from prospective study in these subjects.

Academic Significance and Societal Importance of the Research Achievements

現在、日本では糖尿病性腎症は透析導入の最大の原因でありその対策が必要とされている。日本人2型糖尿病患者763人を対象とした調査を行ったところ、血液中の中性脂肪やリポ蛋白(a)と呼ばれる脂質が多い患者では糖尿病性腎症を合併している割合が多いことがわかった。今後これらの脂質と腎症との関連を明らかにし、治療介入を行うことで腎症の新規発症や悪化を阻止できる可能性が示唆された。

Report

(3 results)
  • 2018 Annual Research Report   Final Research Report ( PDF )
  • 2017 Annual Research Report
  • Research Products

    (2 results)

All 2018 2017

All Journal Article (1 results) (of which Peer Reviewed: 1 results) Presentation (1 results) (of which Int'l Joint Research: 1 results)

  • [Journal Article] Eating Behaviours and Prevalence of Gastroesophageal Reflux Disease in Japanese Patients with Type 2 Diabetes Mellitus: The Dogo Study2017

    • Author(s)
      Takeshita Eiji、Furukawa Shinya、Sakai Takenori、Niiya Tetsuji、Miyaoka Hiroaki、Miyake Teruki、Yamamoto Shin、Senba Hidenori、Yamamoto Yasunori、Arimitsu Eiji、Yagi Sen、Utsunomiya Hiroki、Tanaka Keiko、Ikeda Yoshio、Matsuura Bunzo、Miyake Yoshihiro、Hiasa Yoichi
    • Journal Title

      Canadian Journal of Diabetes

      Volume: - Issue: 3 Pages: 308-3012

    • DOI

      10.1016/j.jcjd.2017.07.007

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Presentation] Breakfast Skipping and Fast Eating are Positively Associated with Metabolic Syndrome Among Japanese People2018

    • Author(s)
      Hidenori Senba, Teruki Miyake, Wataru Kurihara, Sakiko Yoshida, Shin Yamamoto, Shinya Furukawa, Masanori Abe, Bunzo Matsuura, Yoichi Hiasa
    • Organizer
      American Diabetes Association’s 78th Scientific Sessions
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research

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Published: 2017-08-25   Modified: 2020-03-30  

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