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Investigation into mechanism of eating and swallowing disorder and treatment strategy using mice model of Parkinson's disease

Research Project

Project/Area Number 17H06963
Research Category

Grant-in-Aid for Research Activity Start-up

Allocation TypeSingle-year Grants
Research Field Orthodontics/Pediatric dentistry
Research InstitutionNagasaki University

Principal Investigator

YOSHIMI Tomoko  長崎大学, 病院(歯学系), 医員 (20805973)

Project Period (FY) 2017-08-25 – 2019-03-31
Project Status Completed (Fiscal Year 2019)
Budget Amount *help
¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
Fiscal Year 2018: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2017: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Keywords咀嚼 / マウス / 顎運動 / 筋活動 / 筋電図 / 歯科矯正学
Outline of Final Research Achievements

We have developed a synchronized measurement of six-degrees of freedom motion and EMG that apply a motion capture system. With this system, in addition to three-dimensional jaw movement measurement at anatomical analysis points such as the mandibular condyle, occlusal contact with molars and incisors, and masseter and digastric muscles corresponding to each time point on the masticatory movement trajectory. In addition, by administering neurotransmitters to mice, the information transmission mechanism mediated by neurotransmitters plays an important role in the movement control of the masticatory and stomatognathic region and possibility that pharmacotherapy targeting brain transmitter is effective for an eating dysfunction.

Academic Significance and Societal Importance of the Research Achievements

現代において、加齢や脳神経疾患に付随する摂食・嚥下障害が急増していることは周知の事実である。摂食・嚥下障害の病因・病態を解明するためには、生きた実験動物を対象に、無麻酔・覚醒下での詳細な運動記録を継続的に観察する新たな実験系の構築が不可欠である。今回、光学式6自由度顎運動計測システムと筋活動同時計測システムを構築し、顎運動と筋活動のデータをリンクさせた。本研究により、中枢神経系への入力の変調による運動出力への影響を明らかにすることで、これまでその複雑な神経機構から困難とされてきた咀嚼・嚥下運動制御メカニズムの解明に貢献するもであると考える。

Report

(3 results)
  • 2019 Final Research Report ( PDF )
  • 2018 Annual Research Report
  • 2017 Annual Research Report
  • Research Products

    (9 results)

All 2019 2018 2017 Other

All Journal Article (2 results) (of which Int'l Joint Research: 1 results,  Peer Reviewed: 2 results,  Open Access: 2 results) Presentation (6 results) (of which Int'l Joint Research: 2 results) Remarks (1 results)

  • [Journal Article] Development and evaluation of a jaw-tracking system for mice: reconstruction of three-dimensional movement trajectories on an arbitrary point on the mandible2019

    • Author(s)
      Moriuchi E, Hamanaka R, Koga Y, Fujishita A, Yoshimi T, Yasuda G, Kohara H, Yoshida N
    • Journal Title

      Biomedical Engineering Online

      Volume: 18 Issue: 1 Pages: 59-59

    • DOI

      10.1186/s12938-019-0672-z

    • NAID

      120006987707

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Mechanism of motor coordination of masseter and temporalis muscles for increased masticatory efficiency in mice2017

    • Author(s)
      Yoshimi T.、Koga Y.、Nakamura A.、Fujishita A.、Kohara H.、Moriuchi E.、Yoshimi K.、Tsai C.Y.、Yoshida N.
    • Journal Title

      Journal of Oral Rehabilitation

      Volume: 44 Issue: 5 Pages: 363-374

    • DOI

      10.1111/joor.12491

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Presentation] マウス顎運動の特徴―6自由度顎運動および筋電図同期計測システムを用いて―2019

    • Author(s)
      森内絵美,林田佳央理、山田佳奈, 安田豪,吉見知子, 藤下あゆみ,濱中僚, 古賀義之, 吉田教明
    • Organizer
      第78回日本矯正歯科学会学術大会
    • Related Report
      2018 Annual Research Report
  • [Presentation] モーションキャプチャーを用いた6自由度顎運動と筋電図の同期計測による顎口腔機能解析2019

    • Author(s)
      安田豪,山田佳奈,森内絵美,吉見知子,藤下あゆみ,濱中僚,小原悠,古賀義之,吉田教明
    • Organizer
      日本顎口腔機能学会第62回学術大会
    • Related Report
      2018 Annual Research Report
  • [Presentation] Coordination of masticatory muscles and jaw movement in six degrees of freedom depending on food texture during mastication in mice2018

    • Author(s)
      Yoshimi T, Yasuda G, Moriuchi E, Fujishita A, Kohara H, Hamanaka R, Koga Y, Yoshida N
    • Organizer
      The 11th Asian Pacific Orthodontic Conference (APOC 2018)
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 咀嚼筋機能低下が歯の移動に及ぼす影響2018

    • Author(s)
      有薗ケイラ、佛坂斉祉、森田幸子、吉見知子、近藤崇伸、近藤愛理、吉田教明
    • Organizer
      第13回九州矯正歯科学会学術大会
    • Related Report
      2017 Annual Research Report
  • [Presentation] Biomechanical strategy for uprighting of impacted mandibular molar using temporary anchorage devices.2017

    • Author(s)
      Yoshimi T, Koga Y, Yoshida N
    • Organizer
      2017 6th Taiwan Association of Orthodontists (TAO) Resident Meeting, Kaohsiung, Taiwan.
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] モーションキャプチャーを用いた6自由度顎運動計測システムの改良と測定精度2017

    • Author(s)
      安田豪、森内絵美、吉見知子、藤下あゆみ、小原悠、濱中僚、古賀義之、吉田教明
    • Organizer
      第76回日本矯正歯科学会学術大会
    • Related Report
      2017 Annual Research Report
  • [Remarks] Researchmap

    • URL

      https://researchmap.jp/_tmk/

    • Related Report
      2018 Annual Research Report

URL: 

Published: 2017-08-25   Modified: 2021-02-19  

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