• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

Angiotensin II type 1 receptor binding molecule as a therapeutic target for hypertension

Research Project

Project/Area Number 17H06993
Research Category

Grant-in-Aid for Research Activity Start-up

Allocation TypeSingle-year Grants
Research Field Endocrinology
Research InstitutionYokohama City University

Principal Investigator

Kobayashi Ryu  横浜市立大学, 医学部, 助教 (60805612)

Research Collaborator Tamura Koichi  
Project Period (FY) 2017-08-25 – 2019-03-31
Project Status Completed (Fiscal Year 2018)
Budget Amount *help
¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
Fiscal Year 2018: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2017: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Keywords高血圧 / レニン-アンジオテンシン系 / レニンアンジオテンシン系 / 慢性腎臓病
Outline of Final Research Achievements

We examined the in vivo functional role of renal proximal tubule ATRAP in angiotensin-dependent hypertension. We succeeded in generating proximal tubule-specific ATRAP knockout (PT-KO) mice for the firrst time using the Cre/loxP system with Pepck-Cre. ATRAP deficiency in proximal tubules did not exacerbate angiotensin-dependent hypertension in vivo. The results indicate that renal proximal tubule ATRAP has a minor role in angiotensin-dependent hypertension in vivo. (J Am Heart Assoc. 2019;8:e012395. DOI: 10.1161/JAHA.119.012395.)

Academic Significance and Societal Importance of the Research Achievements

これまで,アンジオテンシン受容体結合蛋白ATRAPは,腎尿細管において高い内在性発現レベルを認め,病的刺激下で生じる尿細管1型アンジオテンシン受容体シグナルの過剰活性化および一次性ナトリウム再吸収亢進を抑制することで,高血圧の発症を抑制する新規内在性システムとして機能していることを明らかにしてきた.今回,近位尿細管特異的ATRAP発現制御マウスの作製に成功し検討を行った結果,近位尿細管ではなく遠位尿細管系のATRAPが主に,高血圧発症抑制の内在性システムとして機能している可能性が高いことを明らかにした.尿細管ATRAPの機能を分析したことで,今後新規高血圧治療に結びつく可能性がある.

Report

(3 results)
  • 2018 Annual Research Report   Final Research Report ( PDF )
  • 2017 Annual Research Report
  • Research Products

    (14 results)

All 2019 2018 2017 Other

All Journal Article (6 results) (of which Int'l Joint Research: 6 results,  Peer Reviewed: 6 results,  Open Access: 6 results) Presentation (6 results) (of which Int'l Joint Research: 2 results) Remarks (1 results) Funded Workshop (1 results)

  • [Journal Article] Effects of ATRAP in Renal Proximal Tubules on Angiotensin‐Dependent Hypertension2019

    • Author(s)
      Kinguchi Sho、Wakui Hiromichi、Azushima Kengo、Haruhara Kotaro、Koguchi Tomoyuki、Ohki Kohji、Uneda Kazushi、Matsuda Miyuki、Haku Sona、Yamaji Takahiro、Yamada Takayuki、Kobayashi Ryu、Minegishi Shintaro、Ishigami Tomoaki、Yamashita Akio、Fujikawa Tetsuya、Tamura Kouichi
    • Journal Title

      Journal of the American Heart Association

      Volume: 8 Issue: 8

    • DOI

      10.1161/jaha.119.012395

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Effects of rikkunshito on renal fibrosis and inflammation in angiotensin II-infused mice2019

    • Author(s)
      Azushima Kengo、Uneda Kazushi、Wakui Hiromichi、Ohki Kohji、Haruhara Kotaro、Kobayashi Ryu、Haku Sona、Kinguchi Sho、Yamaji Takahiro、Minegishi Shintaro、Ishigami Tomoaki、Yamashita Akio、Tamura Kouichi
    • Journal Title

      Scientific Reports

      Volume: 9 Issue: 1 Pages: 6201-6201

    • DOI

      10.1038/s41598-019-42657-1

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Angiotensin receptor-binding molecule in leukocytes in association with the systemic and leukocyte inflammatory profile2018

    • Author(s)
      Haruhara Kotaro、Wakui Hiromichi、Azushima Kengo、Kurotaki Daisuke、Kawase Wataru、Uneda Kazushi、Haku Sona、Kobayashi Ryu、Ohki Kohji、Kinguchi Sho、Ohsawa Masato、Minegishi Shintaro、Ishigami Tomoaki、Matsuda Miyuki、Yamashita Akio、Nakajima Hideaki、Tamura Tomohiko、Tsuboi Nobuo、Yokoo Takashi、Tamura Kouichi
    • Journal Title

      Atherosclerosis

      Volume: 269 Pages: 236-244

    • DOI

      10.1016/j.atherosclerosis.2018.01.013

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Angiotensin II Type 1 Receptor-associated Protein Inhibits Angiotensin II-induced Insulin Resistance with Suppression of Oxidative Stress in Skeletal Muscle Tissue2018

    • Author(s)
      Ohki Kohji、Wakui Hiromichi、Kishio Nozomu、Azushima Kengo、Uneda Kazushi、Haku Sona、Kobayashi Ryu、Haruhara Kotaro、Kinguchi Sho、Yamaji Takahiro、Yamada Takayuki、Minegishi Shintaro、Ishigami Tomoaki、Toya Yoshiyuki、Yamashita Akio、Imajo Kento、Nakajima Atsushi、Kato Ikuma、Ohashi Kenichi、Tamura Kouichi
    • Journal Title

      Scientific Reports

      Volume: 8 Issue: 1 Pages: 2846-2846

    • DOI

      10.1038/s41598-018-21270-8

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Angiotensin II Type 1 Receptor‐Associated Protein Regulates Kidney Aging and Lifespan Independent of Angiotensin2017

    • Author(s)
      Uneda Kazushi、Wakui Hiromichi、Maeda Akinobu、Azushima Kengo、Kobayashi Ryu、Haku Sona、Ohki Kohji、Haruhara Kotaro、Kinguchi Sho、Matsuda Miyuki、Ohsawa Masato、Minegishi Shintaro、Ishigami Tomoaki、Toya Yoshiyuki、Atobe Yoshitoshi、Yamashita Akio、Umemura Satoshi、Tamura Kouichi
    • Journal Title

      Journal of the American Heart Association

      Volume: 6 Issue: 8

    • DOI

      10.1161/jaha.117.006120

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Enhancement of intrarenal plasma membrane calcium pump isoform 1 expression in chronic angiotensin II-infused mice2017

    • Author(s)
      Wakui Hiromichi、Sumida Koichiro、Fujita Megumi、Ohtomo Yuta、Ohsawa Masato、Kobayashi Ryu、Uneda Kazushi、Azushima Kengo、Haruhara Kotaro、Yatsu Keisuke、Hirawa Nobuhito、Minegishi Shintaro、Ishigami Tomoaki、Umemura Satoshi、Tamura Kouichi
    • Journal Title

      Physiological Reports

      Volume: 5 Issue: 11 Pages: e13316-e13316

    • DOI

      10.14814/phy2.13316

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Presentation] Leukocyte angiotensin II type 1 receptor binding molecule ATRAP and inflammatory profile in non-communicable diseases2018

    • Author(s)
      Kotaro Haruhara
    • Organizer
      ISN Frontiers 2018
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] AT1受容体結合因子ATRAPの白血球における発現と機能に関する検討2018

    • Author(s)
      春原 浩太郎
    • Organizer
      第22回日本心血管内分泌代謝学会学術総会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 慢性腎臓病における高血圧の進展に腎ATRAP発現の低下が深く関わる2017

    • Author(s)
      小林 竜
    • Organizer
      第39回 腎臓セミナー・Nexus Japan
    • Related Report
      2017 Annual Research Report
  • [Presentation] An angiotensin II type 1 receptor binding molecule has a critical role in hypertension in CKD model2017

    • Author(s)
      Ryu Kobayashi
    • Organizer
      Premium Hypertension Conference
    • Related Report
      2017 Annual Research Report
  • [Presentation] A role of AT1 receptor-associated protein in renal proximal tubule in angiotensin-dependent hypertension2017

    • Author(s)
      Tomoyuki Koguchi
    • Organizer
      第40回日本高血圧学会総会
    • Related Report
      2017 Annual Research Report
  • [Presentation] Leukocyte angiotensin II type 1 receptor-associated protein as a surrogate marker and inhibitory factor of inflammation2017

    • Author(s)
      Kotaro Haruhara
    • Organizer
      ASN Kidney Week 2017
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Remarks] 近位尿細管におけるATRAPと高血圧の病態生理との関連について発表

    • URL

      https://yokohama-medicine.org/news/

    • Related Report
      2018 Annual Research Report
  • [Funded Workshop] ASN Kidney week 20182018

    • Related Report
      2018 Annual Research Report

URL: 

Published: 2017-08-25   Modified: 2020-03-30  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi