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Neurophysiological approach to improve postural control in elderly people

Research Project

Project/Area Number 17H07047
Research Category

Grant-in-Aid for Research Activity Start-up

Allocation TypeSingle-year Grants
Research Field Developmental mechanisms and the body works
Research InstitutionHealth Sciences University of Hokkaido

Principal Investigator

SUZUKI Shinya  北海道医療大学, リハビリテーション科学部, 助教 (20803654)

Project Period (FY) 2017-08-25 – 2019-03-31
Project Status Completed (Fiscal Year 2018)
Budget Amount *help
¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
Fiscal Year 2018: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2017: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Keywordsリハビリテーション / 転倒予防 / 姿勢制御 / 神経可塑性 / 経頭蓋的磁気刺激 / 前庭刺激 / 姿勢反応 / 予測的姿勢調節 / 可塑性 / 可塑的変化
Outline of Final Research Achievements

We investigated methodology to enhance neural functions for postural control in humans. First, we found that arm muscle responses which could be mediated by spinal interneurons were facilitated by galvanic vestibular stimulation. Second, we demonstrated that postural responses associated with voluntary arm movements and corticospinal excitation in leg muscles showed plastic changes after repetitive paired associative stimulation of the motor cortex and peripheral nerve. The present findings suggest that noninvasive brain stimulation modulates neural functions for postural control in intact humans.

Academic Significance and Societal Importance of the Research Achievements

直立姿勢を崩した際に、再び体幹を直立位に保つ、素早く手足を踏み出すといった反応は、高度に自動化されたものであるため、これまで学習が困難であると考えられてきた。本研究では、大脳皮質、前庭あるいは末梢神経への非侵襲的刺激法を用いることにより、姿勢反応に関わる神経経路を賦活させ、可塑的変化を誘導することが可能であることが明らかとなった。これらの知見は、高齢者の転倒予防法の開発に向けた基礎的知見であると考えられる。

Report

(3 results)
  • 2018 Annual Research Report   Final Research Report ( PDF )
  • 2017 Annual Research Report
  • Research Products

    (3 results)

All 2017

All Journal Article (1 results) (of which Peer Reviewed: 1 results,  Open Access: 1 results,  Acknowledgement Compliant: 1 results) Presentation (2 results)

  • [Journal Article] Vestibular stimulation-induced facilitation of cervical premotoneuronal systems in humans.2017

    • Author(s)
      S. Suzuki, T. Nakajima, S. Irie, R. Ariyasu, T. Komiyama and Y. Ohki.
    • Journal Title

      PlosOne

      Volume: 12(4) Issue: 4 Pages: e0175131-e0175131

    • DOI

      10.1371/journal.pone.0175131

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Presentation] ヒト頸髄介在ニューロン系への前庭入力の収束2017

    • Author(s)
      鈴木伸弥、中島剛、入江駿、有安諒平、小宮山伴与志、大木紫
    • Organizer
      第52回日本理学療法学術大会
    • Related Report
      2017 Annual Research Report
  • [Presentation] ガルバニック前庭刺激と反復的コンバインド刺激を併用した新たな間接的皮質脊髄路の強化法2017

    • Author(s)
      鈴木伸弥、中島剛、入江駿、有安諒平、一寸木洋平、小宮山伴与志、大木紫
    • Organizer
      第3回作業療法神経科学研究会学術集会
    • Related Report
      2017 Annual Research Report

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Published: 2017-08-25   Modified: 2020-03-30  

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