Research Project
Grant-in-Aid for Research Activity Start-up
Oral and fecal microbiota from volunteers having inflammatory bowel disease (IBD) were investigated using an advanced next generation sequencing technology and compared with those of healthy volunteers. Oral and fecal samples of ten healthy volunteers and 12 IBD volunteers were sequenced after extracting whole DNA using a 16S rRNA sequencing on the Ion Torrent Personal Genome Machine (I-PGM) System.Streptococcus salivarius and Streptococcus oralis were detected in both oral and fecal samples collected from most volunteers in either group. Streptococcus mutans, Streptococcus gordonii and Actinomyces spp. were present in both samples of few volunteers. Granulicatella adiacens and Streptococcus salivarius were detected in both oral and fecal samples collected from three IBD volunteers. All volunteers from both groups had Streptococcus sinensis in their oral cavity. With few exceptions most volunteers had Streptococcus sinensis in their fecal samples.
近年、IBDの患者数は急増しているにも関わらず、根本原因がわからないため、効果的な予防方法や根治療法は確立していない。本研究によりIBD患者の口腔および腸内細菌叢から細菌学的な知見が得られたことにより、予防方法や根治療法の発見の一助となることが期待される。
All 2019 2018 2017
All Journal Article (2 results) (of which Int'l Joint Research: 2 results, Peer Reviewed: 2 results, Open Access: 2 results) Presentation (10 results) (of which Int'l Joint Research: 2 results) Book (1 results)
Journal of Oral Science
Volume: in press
Journal of Oral Health & Dentistry
Volume: 1 Pages: 39-41
