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Investigation of nutritional treatment for cerebral energy metabolism and brain function improvement

Research Project

Project/Area Number 17H07244
Research Category

Grant-in-Aid for Research Activity Start-up

Allocation TypeSingle-year Grants
Research Field Applied health science
Research InstitutionRitsumeikan University

Principal Investigator

Tsukamoto Hayato  立命館大学, 総合科学技術研究機構, 研究員 (70802099)

Project Period (FY) 2017-08-25 – 2019-03-31
Project Status Completed (Fiscal Year 2018)
Budget Amount *help
¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
Fiscal Year 2018: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2017: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Keywords認知機能 / 脳循環調節機能 / 高血糖 / エネルギー代謝 / 神経栄養因子 / 脳循環 / 低血糖 / 脳エネルギー代謝 / 脳循環自己調節機能 / フラバノール / 乳酸
Outline of Final Research Achievements

This study was conducted to determine the relationship between blood glucose level, which is an important energy substrate for the human brain at rest, and brain behavior-physiological alterations after breakfast glycemic control in human. Moreover, this study was conducted to determine the impact of post-prandial hyperlipidemia on brain behavior-physiological alterations. It is suggested that, as well as skipping breakfast, post-prandial hyperglycemia and hyperlipidemia negatively affect brain behavior-physiological alterations.

Academic Significance and Societal Importance of the Research Achievements

本研究は、日常生活で必ず気にしなければならない朝食摂取(食事の質)が、エネルギー代謝(基質)の観点から脳機能(現象・生理学)にどのような影響を与えているのか示したものである。具体的に、朝食を摂取することは、ブレインヘルスケアのために、非常に重要な行為であることを示した。さらに、高血糖を惹起する高グリセミックインデックス食や、高脂血を招来する高脂肪食は、朝食摂取誘発性の脳への有益性を打ち消してしまう可能性を示した。

Report

(3 results)
  • 2018 Annual Research Report   Final Research Report ( PDF )
  • 2017 Annual Research Report
  • Research Products

    (21 results)

All 2019 2018 2017 Other

All Int'l Joint Research (2 results) Journal Article (5 results) (of which Int'l Joint Research: 5 results,  Peer Reviewed: 5 results,  Open Access: 2 results) Presentation (14 results) (of which Int'l Joint Research: 11 results)

  • [Int'l Joint Research] University of Copenhagen(デンマーク)

    • Related Report
      2018 Annual Research Report
  • [Int'l Joint Research] University of South Wales(英国)

    • Related Report
      2018 Annual Research Report
  • [Journal Article] Dynamic Cerebral Autoregulation Is Maintained during High-Intensity Interval Exercise.2019

    • Author(s)
      Tsukamoto H, Hashimoto T, Olesen ND, Petersen LG, Sorensen H, Nielsen HB, Secher NH, Ogoh S.
    • Journal Title

      Med Sci Sports Exerc.

      Volume: Feb;51(2) Issue: 2 Pages: 372-378

    • DOI

      10.1249/mss.0000000000001792

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Self-selected music-induced reduction of perceived exertion during moderate-intensity exercise does not interfere with post-exercise improvements in inhibitory control2018

    • Author(s)
      Tanaka D, Tsukamoto H, Suga T, Takenaka S, Hamaoka T, Hashimoto T, Isaka T
    • Journal Title

      Physiology and Behavior

      Volume: 194 Pages: 170-176

    • DOI

      10.1016/j.physbeh.2018.05.030

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Maintained exercise-enhanced brain executive function related to cerebral lactate metabolism in men2018

    • Author(s)
      Hashimoto T, Tsukamoto H, Takenaka S, Olesen N.D., Petersen L.G., Sorensen H, Nielsen H.B., Secher N.H., Ogoh S
    • Journal Title

      FASEB Journal

      Volume: 32 Issue: 3 Pages: 1417-1427

    • DOI

      10.1096/fj.201700381rr

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Flavanol-rich cocoa consumption enhances exercise-induced executive function improvements in humans2018

    • Author(s)
      Tsukamoto H, Suga T, Ishibashi A, Takenaka S, Tanaka D, Hirano Y, Hamaoka T, Goto K, Ebi K, Isaka T, and Hashimoto T
    • Journal Title

      Nutrition

      Volume: 46 Pages: 90-96

    • DOI

      10.1016/j.nut.2017.08.017

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] An acute bout of localized resistance exercise can rapidly improve inhibitory control2017

    • Author(s)
      Tsukamoto H, Suga T, Takenaka S, Takeuchi T, Tanaka D, Hamaoka T, Hashimoto T, and Isaka T
    • Journal Title

      PLoS One

      Volume: 12 Issue: 9 Pages: e0184075-e0184075

    • DOI

      10.1371/journal.pone.0184075

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Presentation] 低酸素刺激誘発性の脳循環調節機能低下に対する交感神経活動の役割2019

    • Author(s)
      塚本敏人、ベンジャミン・ステューシー、ダミアン・ベイリー
    • Organizer
      日本体力医学会第33回近畿地方会
    • Related Report
      2018 Annual Research Report
  • [Presentation] Can repeated bouts of exercise improve equally post- exercise inhibitory control as single bout of exercise?2019

    • Author(s)
      Sugimoto T, Suga T, Tsukamoto H, Isaka T, Hashimoto T
    • Organizer
      American College of Sports Medicine’s 66th Annual Meeting
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Catechin-rich green tea intake reduces exercise-induced blood pressure elevation and enhances executive function2019

    • Author(s)
      Tsukamoto H, Hattori T, Hashimoto T
    • Organizer
      24th annual Congress of the European College of Sport Science
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Self-selected music reduces perceived exertion during high-intensity interval exercise without affecting exercise-induced improvements in inhibitory control2019

    • Author(s)
      Sugimoto T, Suga T, Tsukamoto H, Isaka T, Hashimoto T
    • Organizer
      24th annual Congress of the European College of Sport Science
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] The importance of breakfast glycemic control on systemic BDNF and dynamic cerebral autoregulation in men2019

    • Author(s)
      Tsukamoto H, Ishibashi A, Marley CJ, Shinohara Y, Ando S, Bailey DM, Hashimoto T, Ogoh S
    • Organizer
      Physiology 2019
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Post-prandial hyperlipidaemia impairs dynamic cerebral autoregulation2019

    • Author(s)
      Marley CJ, Tsukamoto H, Davis D, Brugniaux JV, Smirl J, Bailey DM
    • Organizer
      Physiology 2019
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Recurrent concussion in retired rugby union players is associated with cerebral hypoperfusion and cognitive impairment2019

    • Author(s)
      Owens TS, Calverley TA, Stacey BS, Marley CJ, Tsukamoto H, Steggall MJ, Jones GL, Fall L, Venables L, Davies B, Williams P, Bailey DM
    • Organizer
      Physiology 2019
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Physical activity confers neuroprotective benefits in young females; focus on improved cerebrovascular reactivity2019

    • Author(s)
      Calverley TA, Marley CJ, Owens TS, Stacey BS, Steggall M, Fall L, Venables L, Tsukamoto H, Bailey DM
    • Organizer
      Physiology 2019
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Dynamic cerebral autoregulation is not impaired during high-intensity interval exercise2018

    • Author(s)
      Tsukamoto H, Hashimoto T, Olesen ND, Petersen LG, Sorensen H, Nielsen HB, Secher NH, Ogoh S
    • Organizer
      23rd annual Congress of the European College of Sport Science
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 低容量高強度間欠的運動が実行機能に及ぼす効果2018

    • Author(s)
      杉本岳史、菅唯志、塚本敏人、田中大智、武中沙葵、下寶賢人、伊坂忠夫、橋本健志
    • Organizer
      第73回日本体力医学会大会
    • Related Report
      2018 Annual Research Report
  • [Presentation] Plasma oxytocin level is enhanced by acute high- intensity interval exercise in men2018

    • Author(s)
      Tsukamoto H, Olesen ND, Petersen LG, Suga T, Sorensen H, Nielsen HB, Ogoh S, Secher NH, Hashimoto T
    • Organizer
      Europhysiology 2018
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] High intensity exercise training prior to major elective surgery is well tolerated and associated with impressive cardiopulmonary improvement2018

    • Author(s)
      Rose G, Calverly TA, Tsukamoto H, Byfield D, Davies R, Appadurai I, Bailey DM
    • Organizer
      Europhysiology 2018
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 間断的運動が運動誘発性の実行機能改善に及ぼす効果2018

    • Author(s)
      杉本岳史、菅唯志、塚本敏人、伊坂忠夫、橋本健志
    • Organizer
      第31回日本トレーニング科学会大会
    • Related Report
      2018 Annual Research Report
  • [Presentation] Effect of low-volume high-intensity interval exercise on post-exercise inhibitory control2018

    • Author(s)
      Sugimoto T, Suga T, Tsukamoto H, Tanaka D, Takenaka S, Shimoho K, Isaka T, Hashimoto T
    • Organizer
      9th Federation of the Asian and Oceanian Physiological Societies Congress
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research

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Published: 2017-08-25   Modified: 2020-03-30  

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