| Project/Area Number |
17J04196
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|---|
| Research Category |
Grant-in-Aid for JSPS Fellows
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| Allocation Type | Single-year Grants |
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| Section | 国内 |
|---|
| Research Field |
Morphological basic dentistry
|
|---|
| Research Institution | Nagasaki University |
|---|
Principal Investigator |
秦 昕 長崎大学, 医歯薬学総合研究科(歯学系), 特別研究員(DC2)
|
|---|
| Project Period (FY) |
2017-04-26 – 2019-03-31
|
| Project Status |
Completed (Fiscal Year 2018)
|
| Budget Amount *help |
¥2,100,000 (Direct Cost: ¥2,100,000)
Fiscal Year 2018: ¥1,000,000 (Direct Cost: ¥1,000,000)
Fiscal Year 2017: ¥1,100,000 (Direct Cost: ¥1,100,000)
|
|---|
| Keywords | osteoporosis / Fkbp5 / 骨代謝学 |
|---|
| Outline of Annual Research Achievements |
To examine the disuse osteoporosis, tail suspension was used for an animal model for unloading. In physiological condition, the bone volume of Fkbp5-/- mice was similar to that of wild-type mice. After tail suspension, bone loss was more severe in Fkbp5-/- mice than wild-type mice in micro-CT analyses.
To examine GC-induced osteoporosis, implantation of prednisolone or injection of Dex was performed in wild-type and Fkbp5-/- mice. The GC treatment reduced cortical bone volume and bone formation more severely in Fkbp5-/- mice than wild-type mice. These finding indicated that Fkbp5 inhibits bone loss in unloading and GC treatment.
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| Research Progress Status |
平成30年度が最終年度であるため、記入しない。
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| Strategy for Future Research Activity |
平成30年度が最終年度であるため、記入しない。
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