| Project/Area Number |
17K00233
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Perceptual information processing
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| Research Institution | Osaka University |
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Principal Investigator |
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| Project Period (FY) |
2017-04-01 – 2020-03-31
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| Project Status |
Completed (Fiscal Year 2019)
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| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2019: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2018: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2017: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
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| Keywords | 光波イメージング / 位相イメージング / デジタルホログラフィ / 散乱イメージング / 位相回復 / コンピュテーショナルイメージング / 光計測 |
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| Outline of Final Research Achievements |
Wavefront imaging is an important technique for visualizing transparent targets, such as biological cells, without staining. Various methods for wavefront imaging have been reported but they have serious several issues, including bulky hardware, quantitativeness, and imaging speeds. We have developed single-shot phase tomographic microscopy by using a random illumination generated from a scattering plate. Furthermore, as an extension of this method, we have extended speckle-correlation imaging, which is a non-invasive method for imaging through scattering media, to a three-dimensional case.
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| Academic Significance and Societal Importance of the Research Achievements |
生体細胞を含む無色透明な試料の撮影には蛍光染色が用いられることが多いが，侵襲性や手間・コストが課題となっている．本研究では非染色透明試料の可視化法として長年研究が進められている光波イメージングの高機能化に取り組んだ．従来法では困難だった小型な筐体，定量性，高速性を伴う光波イメージング法を実現した．また非侵襲に散乱体内部を三次元的に可視化するイメージング手法も実現した．これらの手法はシンプルな光学系で実装できるため汎用性が高く，ライフサイエンスやセキュリティなどの様々な分野での利用が期待される．
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