| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2019: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2018: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2017: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
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| Outline of Final Research Achievements |
Enhancers play a major role in the regulation of tissue-specific gene expression in eukaryotes. In this study, we tried to understand how enhancers work to their target genes mainly from the analyses of genome sequence data. We reanalyzed different sources of Hi-C data and figured out where in the genome shows differential TAD and/or A/B compartment structures among cell types. Then, we checked if the expression pattern of genes in these regions is correlated with the changes of their cell types. Indeed, we found some interesting correlations in their expression and function between B-cells and their lymphomas, for example.
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