| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2020: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2019: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2018: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2017: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
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| Outline of Final Research Achievements |
Endothelial function is considered to be impaired at an early phase of atherosclerosis. The flow-mediated dilation (FMD) test is used to assess the endothelial function. FMD is induced by the wall shear stress exerted by blood flow on endothelial cells. However, the details of the response are not still clear because the path of signal transduction is highly complicated. In this study, we developed a mathematical model that integrates endothelial and smooth muscle cells. We evaluated the model by comparing the results obtained through simulations and experiments on FMD. We demonstrated that the model is applicable for the simulation of the dynamics of intracellular ion movements to analyze the physiological mechanisms and sequence of endothelial function.
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