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Safety and Efficacy of CT Perfusion Evaluation of Reperfusion Therapy in Acute Ischemic Stroke

Research Project

Project/Area Number 17K00426
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Life / Health / Medical informatics
Research InstitutionNational Cardiovascular Center Research Institute

Principal Investigator

INOUE MANABU  国立研究開発法人国立循環器病研究センター, 病院, 医長 (60439362)

Co-Investigator(Kenkyū-buntansha) 豊田 一則  国立研究開発法人国立循環器病研究センター, 病院, 副院長 (50275450)
古賀 政利  国立研究開発法人国立循環器病研究センター, 病院, 部長 (30512230)
山上 宏  国立研究開発法人国立循環器病研究センター, 病院, 医長 (00455552)
Project Period (FY) 2017-04-01 – 2020-03-31
Project Status Completed (Fiscal Year 2019)
Budget Amount *help
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2019: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2018: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2017: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Keywords急性期脳梗塞 / CT / 灌流画像 / 再灌流療法 / 脳神経疾患 / 放射線 / 脳・神経
Outline of Final Research Achievements

Research proceeded smoothly for three years in line with the original plan. We had 700 cases of acute ischemic strokes at our institution every year, and the usefulness of CT perfusion imaging has increased and was considered as a patient selection tool for reperfusion therapy. The European and American guidelines for acute stroke treatment referred to the usefulness and safety of perfusion imaging selection for reperfusion therapy, and these changes also influenced the Japanese stroke guidelines with extended time window. This study had a great impact of achieving CT perfusion imaging for patient selection for early time window and late time window for effective reperfusion therapy, and we believe that out outcome contributed to incorporating perfusion imaging software as a standard tool for acute ischemic stroke treatment in Japan.

Academic Significance and Societal Importance of the Research Achievements

急性期脳梗塞に対してCT造影灌流画像を撮影することで,MRIが撮像できない症例に対しても脳梗塞の判定が可能になり,経静脈的血栓溶解療法や機械的血栓回収術に安全に臨むことができるようになった.本ソフトを利用した研究は本邦初であり,研究期間中に薬機法にて本ソフトRAPIDは国内でも承認を受けている.本研究をもとに,急性期脳梗塞の治療対象患者を増やすべく,実臨床での国内での多数の使用が大いに期待できる結果となった.

Report

(4 results)
  • 2019 Annual Research Report   Final Research Report ( PDF )
  • 2018 Research-status Report
  • 2017 Research-status Report
  • Research Products

    (31 results)

All 2020 2019 2018 2017

All Journal Article (10 results) (of which Int'l Joint Research: 2 results,  Peer Reviewed: 10 results,  Open Access: 7 results) Presentation (10 results) (of which Int'l Joint Research: 3 results,  Invited: 7 results) Book (9 results) Funded Workshop (2 results)

  • [Journal Article] Early Initiation of Direct Oral Anticoagulants After Onset of Stroke and Short- and Long-Term Outcomes of Patients With Nonvalvular Atrial Fibrillation2020

    • Author(s)
      Mizoguchi Tadataka、Tanaka Kanta、Toyoda Kazunori、Yoshimura Sohei、Itabashi Ryo、Takagi Masahito、Todo Kenichi、Shiozawa Masayuki、Yagita Yoshiki、Yoshimoto Takeshi、Terasaki Tadashi、Yamagami Hiroshi、Takizawa Shunya、Inoue Manabu et al. on behalf of the SAMURAI Study Investigators
    • Journal Title

      Stroke

      Volume: 51 Issue: 3 Pages: 883-891

    • DOI

      10.1161/strokeaha.119.028118

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Use of Diffusion‐Weighted Imaging‐Alberta Stroke Program Early Computed Tomography Score (DWI‐ASPECTS) and Ischemic Core Volume to Determine the Malignant Profile in Acute Stroke2019

    • Author(s)
      Yoshimoto Takeshi、Inoue Manabu、Yamagami Hiroshi、Fujita Kyohei、Tanaka Kanta、Ando Daisuke、Sonoda Kazutaka、Kamogawa Naruhiko、Koga Masatoshi、Ihara Masafumi、Toyoda Kazunori
    • Journal Title

      Journal of the American Heart Association

      Volume: 8 Issue: 22

    • DOI

      10.1161/jaha.119.012558

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Validation and iteration of CT perfusion defined malignant profile thresholds for acute ischemic stroke2019

    • Author(s)
      Keenan Kevin J、Christensen Soren、Inoue Manabu、Mlynash Michael、Albers Gregory W、Smith Wade S
    • Journal Title

      International Journal of Stroke

      Volume: 15 Issue: 1 Pages: 55-60

    • DOI

      10.1177/1747493019832987

    • Related Report
      2019 Annual Research Report 2018 Research-status Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Guidelines for Intravenous Thrombolysis (Recombinant Tissue-type Plasminogen Activator), the Third Edition, March 2019: A Guideline from the Japan Stroke Society2019

    • Author(s)
      TOYODA Kazunori、KOGA Masatoshi、IGUCHI Yasuyuki、ITABASHI Ryo、INOUE Manabu、OKADA Yasushi、OGASAWARA Kuniaki、TSUJINO Akira、HASEGAWA Yasuhiro、HATANO Taketo、YAMAGAMI Hiroshi、IWAMA Toru、SHIOKAWA Yoshiaki、TERAYAMA Yasuo、MINEMATSU Kazuo
    • Journal Title

      Neurologia medico-chirurgica

      Volume: 59 Issue: 12 Pages: 449-491

    • DOI

      10.2176/nmc.st.2019-0177

    • NAID

      130007761493

    • ISSN
      0470-8105, 1349-8029
    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Tissue Plasminogen Activator for Cortical Embolism Stroke with Magnetic Resonance Perfusion Imaging: A Report of Two Cases2019

    • Author(s)
      Yi Kenichiro、Inoue Manabu、Irie Kenichi、Mizoguchi Tadataka、Miwa Kaori、Toyoda Kazunori、Koga Masatoshi
    • Journal Title

      Case Reports in Neurology

      Volume: 11 Issue: 2 Pages: 222-229

    • DOI

      10.1159/000501547

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Small but Steady Steps in Stroke Medicine in Japan2019

    • Author(s)
      Toyoda Kazunori、Inoue Manabu、Koga Masatoshi
    • Journal Title

      Journal of the American Heart Association

      Volume: 8 Issue: 16

    • DOI

      10.1161/jaha.119.013306

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Acute CT/MRI perfusion imaging in reperfusion therapy2019

    • Author(s)
      Inoue Manabu
    • Journal Title

      Japanese Journal of Stroke

      Volume: 41 Issue: 1 Pages: 52-57

    • DOI

      10.3995/jstroke.10621

    • NAID

      130007557021

    • ISSN
      0912-0726, 1883-1923
    • Related Report
      2019 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Prior Anticoagulation and Short‐ or Long‐Term Clinical Outcomes in Ischemic Stroke or Transient Ischemic Attack Patients With Nonvalvular Atrial Fibrillation2019

    • Author(s)
      Tokunaga K, Koga M, Itabashi R, ...、Toyoda Kazunori (last author)
    • Journal Title

      Journal of the American Heart Association

      Volume: 8 Issue: 3

    • DOI

      10.1161/jaha.118.010593

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Rivaroxaban concentrations in acute stroke patients with different dosage forms2019

    • Author(s)
      Wada Shinichi、Inoue Manabu、Matsuki Takayuki、Okata Takuya、Kumamoto Masaya、Tagawa Naoki、Okamoto Akira、Miyata Toshiyuki、Ihara Masafumi、Koga Masatoshi、Toyoda Kazunori
    • Journal Title

      PLOS ONE

      Volume: 14 Issue: 3 Pages: e0214132-e0214132

    • DOI

      10.1371/journal.pone.0214132

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Direct oral anticoagulants versus vitamin K antagonists after recent ischemic stroke in patients with atrial fibrillation2019

    • Author(s)
      Seiffge David J.、Paciaroni Maurizio、Wilson Duncan、Koga Masatoshi、Macha Kosmas、Cappellari Manuel、Schaedelin Sabine、Shakeshaft Clare、Takagi Masahito、...、Toyoda Kazunori、他
    • Journal Title

      Annals of Neurology

      Volume: 85 Issue: 6 Pages: 823-834

    • DOI

      10.1002/ana.25489

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Presentation] 脳灌流画像を用いた安全な再灌流療法2019

    • Author(s)
      井上 学
    • Organizer
      第44回日本脳卒中学会学術集会
    • Related Report
      2019 Annual Research Report 2018 Research-status Report
    • Invited
  • [Presentation] AHA/ASA 脳卒中ガイドライン2018レビュー2019

    • Author(s)
      井上 学
    • Organizer
      第36回日本神経治療学会学術集会
    • Related Report
      2019 Annual Research Report
    • Invited
  • [Presentation] AHA/ASA 脳卒中ガイドライン2018レビュー2018

    • Author(s)
      井上 学
    • Organizer
      第36回日本神経治療学会学術集会
    • Related Report
      2018 Research-status Report
    • Invited
  • [Presentation] 診断ソフトRAPIDとはどんなものか?2018

    • Author(s)
      井上 学
    • Organizer
      脳血管内治療ブラッシュアップセミナー2018
    • Related Report
      2018 Research-status Report
    • Invited
  • [Presentation] 教育講演:脳梗塞診療の国内最新情報2018

    • Author(s)
      井上 学
    • Organizer
      第59回日本神経学会総会
    • Related Report
      2018 Research-status Report
    • Invited
  • [Presentation] Does Intracranial Atherosclerotic Disease With Low NIHSS Effect Outcomes in Reperfusion Therapy Eligible Acute Stroke Patients?2018

    • Author(s)
      井上 学
    • Organizer
      International Stroke Conference
    • Related Report
      2017 Research-status Report
    • Int'l Joint Research
  • [Presentation] Volumetric and Hemorrhagic Assessment of Reperfusion Therapy Eligible Patients in Acute Ischemic Stroke by MRI.2017

    • Author(s)
      井上 学
    • Organizer
      European Stroke Organisation Conference
    • Related Report
      2017 Research-status Report
    • Int'l Joint Research
  • [Presentation] Volumetric DWI Malignant Profile Assessment in Acute Ischemic Patients With Reperfusion Therapy.2017

    • Author(s)
      井上 学
    • Organizer
      International Stroke Conference
    • Related Report
      2017 Research-status Report
    • Int'l Joint Research
  • [Presentation] 急性期脳梗塞におけるPerfusion Imagingの有用性2017

    • Author(s)
      井上 学
    • Organizer
      第60回日本脳循環代謝学会学術集会
    • Related Report
      2017 Research-status Report
    • Invited
  • [Presentation] 急性期CT/MR造影灌流画像による再灌流療法の適応2017

    • Author(s)
      井上 学
    • Organizer
      第42回日本脳卒中学会学術集会
    • Related Report
      2017 Research-status Report
    • Invited
  • [Book] 血栓回収療法 Technical Tips 治療成功のコツ!画像診断のポイント2019

    • Author(s)
      吉村 紳一
    • Total Pages
      224
    • Publisher
      メディカ出版
    • ISBN
      9784840469081
    • Related Report
      2019 Annual Research Report
  • [Book] 脳血管内治療の進歩-ブラッシュアップセミナー2018 灌流ミスマッチ診断ソフトの意義2019

    • Author(s)
      坂井 信幸
    • Total Pages
      204
    • Publisher
      診断と治療社
    • ISBN
      9784787823786
    • Related Report
      2019 Annual Research Report
  • [Book] リハビリテーション医療に活かす画像のみかた 脳画像のみかた2019

    • Author(s)
      水間 正澄、川手 信行
    • Total Pages
      252
    • Publisher
      南江堂
    • ISBN
      9784524259076
    • Related Report
      2019 Annual Research Report
  • [Book] Medical Practice 組織評価に基づく急性期脳梗塞治療 次世代脳灌流解析プログラムの臨床応用2019

    • Author(s)
      井上 学
    • Total Pages
      176
    • Publisher
      文光堂
    • Related Report
      2019 Annual Research Report
  • [Book] RadFan 脳CT Perfusionで見える、脳卒中治療の新戦略2019

    • Author(s)
      井上 学
    • Total Pages
      88
    • Publisher
      メディカルアイ
    • Related Report
      2019 Annual Research Report
  • [Book] 脳卒中治療ガイドライン2015[追補2019対応] 井上 学.脳梗塞・TIA実務担当 p.54-1382019

    • Author(s)
      井上 学
    • Total Pages
      345
    • Publisher
      協和企画
    • Related Report
      2019 Annual Research Report
  • [Book] RadFan2019

    • Author(s)
      井上 学
    • Total Pages
      88
    • Publisher
      メディカルアイ
    • Related Report
      2018 Research-status Report
  • [Book] 循環器病研究の進歩2018

    • Author(s)
      井上 学
    • Total Pages
      86
    • Publisher
      協和企画
    • Related Report
      2018 Research-status Report
  • [Book] 週間日本医事新報2017

    • Author(s)
      井上 学
    • Total Pages
      1
    • Publisher
      日本医事新報社
    • Related Report
      2017 Research-status Report
  • [Funded Workshop] International Stroke Conference2017

    • Related Report
      2017 Research-status Report
  • [Funded Workshop] European Stroke Organisation Conference2017

    • Related Report
      2017 Research-status Report

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Published: 2017-04-28   Modified: 2021-02-19  

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