Sexual differences in neuroprotective effect and brain fragility by mouse brain sex hormones
Project/Area Number |
17K00569
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Risk sciences of radiation and chemicals
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Research Institution | Hiroshima University |
Principal Investigator |
Yamazaki Takeshi 広島大学, 統合生命科学研究科(総), 教授 (30192397)
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Project Period (FY) |
2017-04-01 – 2020-03-31
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Project Status |
Completed (Fiscal Year 2019)
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Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2019: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2018: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2017: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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Keywords | メチル水銀 / アクアポリン / 酸化ストレス / 脳室拡大 / アストロサイト / 中脳水道 / エストラジオール / 性差 |
Outline of Final Research Achievements |
Methyl mercury chloride was orally administered to ICR mice. Administration of half the amount of methylmercury that causes typical toxicity in mice induced oxidative stress, activation of astrocytes, protein expression of aquaporin and edema, specifically in periaqueductal gray matter. The amount of mercury accumulated in this region was similar to that in the cerebral cortex and cerebellum, where the effects of methylmercury toxicity were not observed. These results revealed that the periaqueductal gray matter was particularly vulnerable to methylmercury. We are currently investigating the relationship between sex steroid hormones and sex differences in toxicity to this new toxicity and other neurotoxicity.
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Academic Significance and Societal Importance of the Research Achievements |
水銀はいまだにかなりの量が環境に放出されており,メチル水銀によるヒトの低濃度汚染のリスクは続いている。一方,水俣病の原因が明らかになって60年以上経過した現在でも,メチル水銀による脳障害のメカニズムやその性差には不明な点が多い。この研究では,低用量のメチル水銀による新規の脳神経毒性が見出された。これはマウスでの結果であるが,ヒトの低濃度汚染の影響部位の予想にも,哺乳類の神経毒性の性差のメカニズム解明にも寄与する研究成果である。
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Report
(4 results)
Research Products
(17 results)
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[Journal Article] Ad4BP/SF-1 regulates cholesterol synthesis to boost the production of steroids2018
Author(s)
Takashi Baba, Hiroyuki Otake, Miki Inoue, Tetsuya Sato, Yasuhiro Ishihara, Ju-Yeon Moon, Megumi Tsuchiya, Kanako Miyabayashi, Hidesato Ogawa, Yuichi Shima, Lixiang Wang, Ryuichiro Sato, Takeshi Yamazaki, Mikita Suyama, Masatoshi Nomura, Man Ho Choi, Yasuyuki Ohkawa & Ken-ichirou Morohashi
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Journal Title
Communications Biology
Volume: 1
Issue: 1
Pages: 1-9
DOI
NAID
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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[Journal Article] Differential lactate and cholesterol synthetic activities in XY and XX Sertoli cells.2017
Author(s)
Shishido Y, Baba T, Sato T, Shima Y, Miyabayashi K, Inoue M, Akiyama H, Kimura H, Kanal Y, Ishihara Y, Haraguchi S, Miyazaki A, Rozman D, Yamazaki T, Choi MH, Ohkawa Y, Suyama M, Morohashi KI
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Journal Title
Sci Rep
Volume: 7
Issue: 1
Pages: 41912-41912
DOI
NAID
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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