| Project/Area Number |
17K00574
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Risk sciences of radiation and chemicals
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| Research Institution | Daiichi University, College of Pharmaceutical Sciences |
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Principal Investigator |
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| Project Period (FY) |
2017-04-01 – 2021-03-31
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| Project Status |
Completed (Fiscal Year 2020)
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| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2019: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2018: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2017: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
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| Keywords | 体内動態 / 臭素化合物 / 海藻 / 天然化合物 / 曝露量 / GC/MS / 母乳 / ヒト / 残留 |
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| Outline of Final Research Achievements |
The origin of naturally produced and persistent brominated biphenyls (OH-BDEs) was found to be marine alga (Sargassum sp.) from east Asia. These OH-BDEs were accumulated as methoxylated products in higher trophic organisms such as cetaceans, followed by fish. Human exposure to MeO-BDEs via diet may result in hepatic metabolism by CYP2B6 to OH-BDEs, of which 6-OH-BDE47 may be retained in blood of human.
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| Academic Significance and Societal Importance of the Research Achievements |
ヒトや海洋哺乳動物には残留性有機汚染物質(POPs)と同レベルで天然由来の臭素化ビフェノール類(OH-BDE)が広範囲で検出されている。本研究では、海藻由来のOH-BDEのメチル化体が、食物連鎖により魚介類やヒト食事に検出されること、またヒトに取り込まれたMeO-PBDEは容易に脱メチル化されやすいことを明らかにした。OH-BDEは、抗菌・抗酸化能や内分泌かく乱性を有すると考えられ、そのヒト影響研究の基礎資料となる。
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