• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

Identification of components of orally administered Pyropia spp. extract and elucidation of the mechanisms underlying its insulin-like effects

Research Project

Project/Area Number 17K00825
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Eating habits
Research InstitutionPrefectural University of Kumamoto

Principal Investigator

tomoyori hiroko  熊本県立大学, 環境共生学部, 准教授 (10347700)

Co-Investigator(Kenkyū-buntansha) 池田 剛  崇城大学, 薬学部, 教授 (80295138)
Project Period (FY) 2017-04-01 – 2020-03-31
Project Status Completed (Fiscal Year 2019)
Budget Amount *help
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2019: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2018: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2017: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Keywords糖尿病 / インスリン / 機能性食品 / 海藻 / 海苔 / のり / 血糖降下作用 / 実験動物 / ラット / マウス / 血糖値
Outline of Final Research Achievements

The study aimed was to identify the components of orally Pyropia spp. extract (Nori extract) and to elucidate the mechanisms underlying its insulin-like effects. It has previously been shown that Nori extract suppresses blood glucose in vivo by exerting insulin-like effects. Here, we assessed the inhibitory effects of Nori extract on carbohydrate-digesting enzymes and its antioxidant activity. These factors were not involved in blood glucose suppression, indicating that the suppressive effects of Nori extract is due to an insulin-like effect and is not mediated by other factors.Correlations were evident between Nori grade and parameters including insulin-like effect, crude soluble dietary fiber fraction content, protein content, and antioxidant activity. Based on these correlations, we suggest that low-grade Nori extract would be advantageous in identifying components exhibiting insulin-like effects.

Academic Significance and Societal Importance of the Research Achievements

インスリンは糖尿病の治療に欠かせないホルモンであり、その補充には皮下投与が一般的であるが、我々はこれまで経口摂取可能なインスリン様作用成分をのり由来成分中に見出してきている。本研究の結果から廃棄品質ののりが成分抽出に適していることが明らかになり、有効活用が期待される。さらに、高品質ののりにはたんぱく質や抗酸化性成分が、低品質ののりには水溶性食物繊維画分やインスリン様作用成分が多く含まれることが明らかになり、のりはどの品質でも血糖降下作用が期待できる。

Report

(4 results)
  • 2019 Annual Research Report   Final Research Report ( PDF )
  • 2018 Research-status Report
  • 2017 Research-status Report
  • Research Products

    (6 results)

All 2019 2018 2017

All Presentation (5 results) (of which Invited: 1 results) Book (1 results)

  • [Presentation] 脂肪分解抑制作用を示す海苔由来低分子画分の分離および品質差による違い2019

    • Author(s)
      鴨美優紀, 野坂瑠璃子, 市木美帆, 阿蘇品里紗, 友寄博子
    • Organizer
      日本食品科学工学会
    • Related Report
      2019 Annual Research Report
  • [Presentation] 海苔由来低分子画分の長期摂取による高インスリン血症改善作用2018

    • Author(s)
      友寄 博子、浅川牧夫
    • Organizer
      日本栄養・食糧学会
    • Related Report
      2018 Research-status Report
  • [Presentation] 海苔の成分組成に及ぼす品質差による影響2018

    • Author(s)
      友寄博子,大田黒 香織、阿蘇品里紗、市木美帆、野坂瑠璃子
    • Organizer
      日本未病システム学会
    • Related Report
      2018 Research-status Report
  • [Presentation] 食品成分による生体機能調節の可能性2018

    • Author(s)
      友寄博子
    • Organizer
      糖尿病学会
    • Related Report
      2018 Research-status Report
    • Invited
  • [Presentation] 海苔由来低分子画分の長期摂取による高インスリン血症改善作用2017

    • Author(s)
      友寄博子, 浅川牧夫
    • Organizer
      日本機能性食品医用学会
    • Related Report
      2017 Research-status Report
  • [Book] アマノリ生物学の最前線2019

    • Author(s)
      三上 浩司編
    • Total Pages
      355
    • Publisher
      GlobeEdit
    • ISBN
      6139413575
    • Related Report
      2019 Annual Research Report

URL: 

Published: 2017-04-28   Modified: 2021-02-19  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi