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Effect of Baked milk for milk allergy

Research Project

Project/Area Number 17K00831
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Eating habits
Research InstitutionNagoya University of Arts and Sciences

Principal Investigator

IZUMI HIDEHIKO  名古屋学芸大学, 管理栄養学部, 教授 (80351211)

Project Period (FY) 2017-04-01 – 2021-03-31
Project Status Completed (Fiscal Year 2020)
Budget Amount *help
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2019: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2018: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Fiscal Year 2017: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Keywords牛乳アレルギー / ベイクドミルク / アレルギー
Outline of Final Research Achievements

It has been suggested that patients with cow’s milk allergy can ingest baked milk without adverse reactions, although this has not been characterized sufficiently. Here, we investigated the solubility and digestibility of αs1-casein and β-lactoglobulin when milk was mixed with gluten, and then baked. Samples were analyzed using SDS-PAGE and immunoblot. αs1-Casein and β-lactoglobulin in the PBS extract from the baked milk with gluten were not detected compared with that in the milk. αs1-Casein and β-lactoglobulin were detected as insoluble fractions. The digestibility of αs1-casein in BM was deceased compared with that in the non-baked milk. The insolubilized β-lactoglobulin was not digested and thus remained.

Academic Significance and Societal Importance of the Research Achievements

本研究により、ベイクドミルク中の主要アレルゲンであるαs1-カゼインおよびβ-ラクトグロブリンの性質は、牛乳中とは異なり不溶化し、消化性も低下していることが明らかとなった。この性質の変化により、患者の牛乳摂取可能量を増加させること、食事のバリエーションを増加させることができると考える。さらに、免疫療法の導入初期に利用することで、患児が直面している微量の誤食によるアナフィラキシーのリスクを軽減できると考える。

Report

(5 results)
  • 2020 Annual Research Report   Final Research Report ( PDF )
  • 2019 Research-status Report
  • 2018 Research-status Report
  • 2017 Research-status Report
  • Research Products

    (5 results)

All 2020 2019 2018

All Journal Article (3 results) (of which Int'l Joint Research: 1 results,  Peer Reviewed: 3 results,  Open Access: 2 results) Presentation (2 results)

  • [Journal Article] Changes in Solubility, Allergenicity, and Digestibility of Cow's Milk Proteins in Baked Milk.2020

    • Author(s)
      Michihiro Naito, Chikako Yamada, Tsukasa Matsuda, Hidehiko Izumi
    • Journal Title

      Food Science and Technology Research

      Volume: 26 Pages: 129-138

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Composition of Cow’s Milk Proteins with Processing2019

    • Author(s)
      内藤宙大,山田千佳子,和泉秀彦
    • Journal Title

      Nippon Shokuhin Kagaku Kogaku Kaishi

      Volume: 66 Issue: 6 Pages: 195-200

    • DOI

      10.3136/nskkk.66.195

    • NAID

      130007676999

    • ISSN
      1341-027X, 1881-6681
    • Year and Date
      2019-06-15
    • Related Report
      2019 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] 牛乳アレルゲンのIgEエピトープ2018

    • Author(s)
      内藤宙大,山田千佳子,和泉秀彦
    • Journal Title

      名古屋栄養科学雑誌

      Volume: 4 Pages: 67-72

    • NAID

      40021992816

    • Related Report
      2018 Research-status Report
    • Peer Reviewed
  • [Presentation] 牛乳経口免疫療法によるカゼイン特異抗体の変動2019

    • Author(s)
      内藤宙大、山田千佳子、和泉秀彦
    • Organizer
      第73回日本栄養・食糧学会大会
    • Related Report
      2018 Research-status Report
  • [Presentation] ベイクドミルク中のカゼインの吸収性2018

    • Author(s)
      内藤宙大、山田千佳子、和泉秀彦
    • Organizer
      第72回日本栄養・食糧学会大会
    • Related Report
      2017 Research-status Report

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Published: 2017-04-28   Modified: 2022-01-27  

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