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The study for the molecular metabolic basis of novel glycosylation sensor molecules

Research Project

Project/Area Number 17K00846
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Eating habits
Research InstitutionSaitama Medical University (2019)
The University of Tokyo (2017-2018)

Principal Investigator

IZUMIDA Yoshihiko  埼玉医科大学, 医学部, 教授 (80384410)

Project Period (FY) 2017-04-01 – 2020-03-31
Project Status Completed (Fiscal Year 2019)
Budget Amount *help
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2019: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2018: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
Fiscal Year 2017: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Keywords糖鎖 / 代謝 / 脂質 / 非アルコール性脂肪肝炎 / 免疫難病 / 神経 / ミトコンドリア / 酸化ストレス / エネルギー / 非アルコール性脂肪性肝炎 / 炎症 / 脂質代謝 / 糖代謝 / エネルギー代謝 / シグナル伝達 / 神経科学 / 情報工学
Outline of Final Research Achievements

The neural pathway via hepatic vagus nerve causes physiological lipolysis based on hepatic glycogen consumption information, in turn translating hepatic metabolism pattern as common nervous system information. As a result of working on the elucidation of this mechanism, by inhibiting the molecule X synthesized from the liver, Triglyceride in adipose tissue is preferentially used as an energy substrate of hepatocytes as compared with glycogen. Moreover the adipose tissue would be reprogrammed into brown adipose tissue. As a sum of these mechanisms, hepatic β-oxidation enhancement, inflammation suppression, and oxidative stress reduction could be triggered after the induction of RNAi on the molecule X. Based on this knowledge, PCT international patent was published.

Academic Significance and Societal Importance of the Research Achievements

特許取得し開発研究を進めるとともに医薬品開発につなげていく。 さらに神経系代謝制御のメカニズムの探求し、さらに代謝を決定する細胞内器質の性状を糖鎖構造による変化から推測可能とする新たな代謝生理学へとつなげ、学術的発展に寄与できるように研究を進める。

Report

(4 results)
  • 2019 Annual Research Report   Final Research Report ( PDF )
  • 2018 Research-status Report
  • 2017 Research-status Report
  • Research Products

    (10 results)

All 2020 2019 2018 2017

All Journal Article (5 results) (of which Int'l Joint Research: 3 results,  Peer Reviewed: 5 results,  Open Access: 5 results,  Acknowledgement Compliant: 1 results) Presentation (2 results) Patent(Industrial Property Rights) (3 results) (of which Overseas: 3 results)

  • [Journal Article] Insulin- and Lipopolysaccharide-Mediated Signaling in Adipose Tissue Macrophages Regulates Postprandial Glycemia through Akt-mTOR Activation2020

    • Author(s)
      Toda G、Soeda K、Okazaki Y、Kobayashi N、Masuda Y、Arakawa N、Suwanai H、Masamoto Y、Izumida Y、Kamei N、Sasako T、Suzuki R、Kubota T、Kubota N、Kurokawa M、Tobe K、Noda T、Honda K、Accili D、Yamauchi T、Kadowaki T、Ueki K
    • Journal Title

      Molecular Cell

      Volume: 79 Issue: 1 Pages: 1-2

    • DOI

      10.1016/j.molcel.2020.04.033

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Glucocorticoid receptor suppresses gene expression of Rev-erbα (Nr1d1) through interaction with the CLOCK complex2019

    • Author(s)
      Murayama Yuki, Takafumi Miyamoto, et al.
    • Journal Title

      FEBS Letters

      Volume: 593 Issue: 4 Pages: 423-432

    • DOI

      10.1002/1873-3468.13328

    • Related Report
      2019 Annual Research Report 2018 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] The association between health literacy levels and patient-reported outcomes in Japanese type 2 diabetic patients2019

    • Author(s)
      Ueno Haruka、Ishikawa Hirono、Suzuki Ryo、Izumida Yoshihiko、Ohashi Yumiko、Yamauchi Toshimasa、Kadowaki Takashi、Kiuchi Takahiro
    • Journal Title

      SAGE Open Medicine

      Volume: 7 Pages: 1-10

    • DOI

      10.1177/2050312119865647

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] A candidate functional SNP rs7074440 in TCF7L2 alters gene expression through C-FOS in hepatocytes.2018

    • Author(s)
      Piao X, Yahagi N, Takeuchi Y, Aita Y, Murayama Y, Sawada Y, Shikama A, Masuda Y, Nishi-Tatsumi M, Kubota M, Izumida Y, Sekiya M, Matsuzaka T, Nakagawa Y, Sugano Y, Iwasaki H, Kobayashi K, Yatoh S, Suzuki H, Yagyu H, Kawakami Y, Shimano H.
    • Journal Title

      FEBS Lett.

      Volume: 592(3) Issue: 3 Pages: 422-433

    • DOI

      10.1002/1873-3468.12975

    • Related Report
      2018 Research-status Report 2017 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] A key role of nuclear factor Y in the refeeding response of fatty acid synthase in adipocytes.2017

    • Author(s)
      Nishi-Tatsumi M, Yahagi N, Takeuchi Y, Toya N, Takarada A, Murayama Y, Aita Y, Sawada Y, Piao X, Oya Y, Shikama A, Masuda Y, Kubota M, Izumida Y, Matsuzaka T, Nakagawa Y, Sekiya M, Iizuka Y, Kawakami Y, Kadowaki T, Yamada N, Shimano H.
    • Journal Title

      FEBS Lett

      Volume: 591 Issue: 7 Pages: 965-978

    • DOI

      10.1002/1873-3468.12620

    • Related Report
      2017 Research-status Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Presentation] 糖質と脂肪酸のエネルギー基質動員を制御する分子基盤の探求2019

    • Author(s)
      泉田欣彦、和田亘弘、矢作直也、武内謙憲、李恩旭、呼延延人、升田紫、 沢田義一、戸谷直樹、 朴賢英、會田雄一、志鎌明人、飯塚陽子、島野仁、山内敏正、門脇孝
    • Organizer
      第62回日本糖尿病学会
    • Related Report
      2019 Annual Research Report
  • [Presentation] 多価不飽和脂肪酸(PUFA)によるSREBP-1特異的な抑制機序の解明2019

    • Author(s)
      升田紫、矢作直也、武内謙憲、和田亘弘、李恩旭、呼延宣人、Saber Zahara Mehrazad, 沢田義一、村山友樹、會田雄一、西(辰巳)真貴子、泉田欣彦、飯塚陽子、井高啓史、片岡一則、島野仁、門脇孝
    • Organizer
      第62回日本糖尿病学会
    • Related Report
      2019 Annual Research Report
  • [Patent(Industrial Property Rights)] Patent2017

    • Inventor(s)
      泉田欣彦、和田亘弘、升田紫、門脇孝
    • Industrial Property Rights Holder
      泉田欣彦、和田亘弘、升田紫、門脇孝
    • Industrial Property Rights Type
      特許
    • Filing Date
      2017
    • Acquisition Date
      2019
    • Related Report
      2019 Annual Research Report
    • Overseas
  • [Patent(Industrial Property Rights)] OBESITY-RELATED DISEASE THERAPEUTIC AGENT BY HEPATIC SECRETORY METABOLIC REGULATOR INHIBITORY ACTION2017

    • Inventor(s)
      Yoshihiko IZUMIDA
    • Industrial Property Rights Holder
      Yoshihiko IZUMIDA
    • Industrial Property Rights Type
      特許
    • Filing Date
      2017
    • Related Report
      2018 Research-status Report
    • Overseas
  • [Patent(Industrial Property Rights)] WO/2017/1959012017

    • Inventor(s)
      Yoshihiko IZUMIDA
    • Industrial Property Rights Holder
      Yoshihiko IZUMIDA
    • Industrial Property Rights Type
      特許
    • Filing Date
      2017
    • Acquisition Date
      2017
    • Related Report
      2017 Research-status Report
    • Overseas

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Published: 2017-04-28   Modified: 2023-03-23  

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