• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

Control of obesity and inflammatory bowel disease by polyunsaturated fatty acid adjusted diet

Research Project

Project/Area Number 17K00856
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Eating habits
Research InstitutionDokkyo Medical University (2018-2019)
Yamaguchi University (2017)

Principal Investigator

Nobuko Tokuda  獨協医科大学, 医学部, 教授 (70227578)

Co-Investigator(Kenkyū-buntansha) 大和田 祐二  東北大学, 医学系研究科, 教授 (20292211)
山本 由似  東北医科薬科大学, 医学部, 助教 (80635087)
Project Period (FY) 2017-04-01 – 2020-03-31
Project Status Completed (Fiscal Year 2019)
Budget Amount *help
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2019: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2018: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2017: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Keywords脂肪酸 / 炎症 / 肥満 / FABP / 腸炎 / 組織再生 / 腸 / 微小環境 / 消化管 / 栄養学 / 細菌 / 細胞・組織 / 脂質 / 免疫学
Outline of Final Research Achievements

Intake of n-3 fatty acid deficient diet and deficiency of FABP7 (brain-type fatty acid binding protein), which has high affinity for n-3 fatty acids, may affect weight gain, peripheral immune cell number and differentiation. FABP7 deficiency suppressed food intake and obesity when a high-fat diet was consumed. FABP7 has also been shown to play a role in regulating inflammation and protecting cell death. Another polyunsaturated fatty acid regulator has also been shown to control the exacerbation of inflammatory bowel disease.

Academic Significance and Societal Importance of the Research Achievements

多価不飽和脂肪酸が肥満や炎症に与える影響について、これまで栄養学的な知見によって確認されてきた事項を、動物モデルや細胞学的なデータから解析し、その機序の一旦を示すことができた。定常状態の解析結果については疾患の予防、炎症時の解析結果については疾患の機序の解明や新しい治療の開発に繋げることができると考えられる。

Report

(4 results)
  • 2019 Annual Research Report   Final Research Report ( PDF )
  • 2018 Research-status Report
  • 2017 Research-status Report
  • Research Products

    (87 results)

All 2020 2019 2018 2017 2016 Other

All Journal Article (25 results) (of which Int'l Joint Research: 8 results,  Peer Reviewed: 23 results,  Open Access: 17 results,  Acknowledgement Compliant: 1 results) Presentation (60 results) (of which Int'l Joint Research: 8 results,  Invited: 6 results) Remarks (2 results)

  • [Journal Article] TRAF5 promotes plasmacytoid dendritic cell development from bone marrow progenitors2020

    • Author(s)
      Kobayashi Shuhei、Shiota Yuka、Kawabe Takeshi、Phung Hai The、Maruyama Takashi、Owada Yuji、So Takanori、Ishii Naoto
    • Journal Title

      Biochemical and Biophysical Research Communications

      Volume: 521 Issue: 2 Pages: 353-359

    • DOI

      10.1016/j.bbrc.2019.10.123

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 脂肪酸結合蛋白質による脂質ラフトを介した細胞外部刺激応答の調節機構2020

    • Author(s)
      香川慶輝, 大和田祐二
    • Journal Title

      アグリバイオ

      Volume: 4 Pages: 74-77

    • NAID

      40022166987

    • Related Report
      2019 Annual Research Report
  • [Journal Article] Novel Targeting to XCR1+ Dendritic Cells Using Allogeneic T Cells for Polytopical Antibody Responses in the Lymph Nodes2019

    • Author(s)
      Kitazawa Yusuke、Ueta Hisashi、Sawanobori Yasushi、Katakai Tomoya、Yoneyama Hiroyuki、Ueha Satoshi、Matsushima Kouji、Tokuda Nobuko、Matsuno Kenjiro
    • Journal Title

      Frontiers in Immunology

      Volume: 10 Pages: 1195-1195

    • DOI

      10.3389/fimmu.2019.01195

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] The guanylate cyclase C agonist linaclotide ameliorates the gut?cardio?renal axis in an adenine-induced mouse model of chronic kidney disease2019

    • Author(s)
      Nanto-Hara F、Kanemitsu Y、Fukuda S、Kikuchi K、Asaji K、Saigusa D、Iwasaki T、Ho H、Mishima E、Suzuki T、Suzuki C、Tsukimi T、Matsuhashi T、Oikawa Y、Akiyama Y、Kure S、Owada Y、Tomioka Y、Soga T、Ito S, Abe T
    • Journal Title

      Nephrology Dialysis Transplantation

      Volume: 35 Pages: 250-264

    • DOI

      10.1093/ndt/gfz126

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] FABP7 Protects Astrocytes Against ROS Toxicity via Lipid Droplet Formation2019

    • Author(s)
      Islam Ariful、Kagawa Yoshiteru、Miyazaki Hirofumi、Shil Subrata Kumar、Umaru Banlanjo A.、Yasumoto Yuki、Yamamoto Yui、Owada Yuji
    • Journal Title

      Molecular Neurobiology

      Volume: - Issue: 8 Pages: 5763-5779

    • DOI

      10.1007/s12035-019-1489-2

    • Related Report
      2019 Annual Research Report 2018 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] TNF Receptor-Associated Factor 5 Limits Function of Plasmacytoid Dendritic Cells by Controlling IFN Regulatory Factor 5 Expression2019

    • Author(s)
      Kobayashi Shuhei、Sakurai Tsuyoshi、So Takanori、Shiota Yuka、Asao Atsuko、Phung Hai The、Tanaka Riou、Kawabe Takeshi、Maruyama Takashi、Kanno Emi、Kawakami Kazuyoshi、Owada Yuji、Ishii Naoto
    • Journal Title

      The Journal of Immunology

      Volume: 203 Issue: 6 Pages: 1447-1456

    • DOI

      10.4049/jimmunol.1900188

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] The Role of Fatty Acid Binding Protein 7 in Spinal Cord Astrocytes in a Mouse Model of Experimental Autoimmune Encephalomyelitis2019

    • Author(s)
      Kamizato Kenyu、Sato Sho、Shil Subrata Kumar、Umaru Banlanjo A.、Kagawa Yoshiteru、Yamamoto Yui、Ogata Masaki、Yasumoto Yuki、Okuyama Yuko、Ishii Naoto、Owada Yuji、Miyazaki Hirofumi
    • Journal Title

      Neuroscience

      Volume: - Pages: 120-129

    • DOI

      10.1016/j.neuroscience.2019.03.050

    • Related Report
      2019 Annual Research Report 2018 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Gut microbiome-derived phenyl sulfate contributes to albuminuria in diabetic kidney disease2019

    • Author(s)
      Kikuchi Koichi、Saigusa Daisuke、Kanemitsu Yoshitomi、Matsumoto Yotaro、Tsukamoto Hiroki、Abe Takaaki
    • Journal Title

      Nature Communications

      Volume: 10 Issue: 1 Pages: 1835-1835

    • DOI

      10.1038/s41467-019-09735-4

    • Related Report
      2019 Annual Research Report 2018 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] 脂肪酸結合蛋白質FABP7による脂質ラフト機能調節メカニズムの解明2019

    • Author(s)
      香川慶輝, 大和田祐二
    • Journal Title

      月刊「細胞」

      Volume: 51 Pages: 28-30

    • Related Report
      2019 Annual Research Report
  • [Journal Article] Effects of FABP7 on functional recovery after spinal cord injury in adult mice2019

    • Author(s)
      Senbokuya Nobuo、Yoshioka Hideyuki、Yagi Takashi、Owada Yuji、Kinouchi Hiroyuki
    • Journal Title

      Journal of Neurosurgery: Spine

      Volume: - Issue: 2 Pages: 1-7

    • DOI

      10.3171/2019.2.spine18844

    • Related Report
      2018 Research-status Report
    • Peer Reviewed
  • [Journal Article] Evaluation of the role of fatty acid-binding protein 7 in controlling schizophrenia-relevant phenotypes using newly established knockout mice2019

    • Author(s)
      Shimamoto-Mitsuyama Chie、Ohnishi Tetsuo、Balan Shabeesh、Ohba Hisako、Watanabe Akiko、Maekawa Motoko、Hisano Yasuko、Iwayama Yoshimi、Owada Yuji、Yoshikawa Takeo
    • Journal Title

      Schizophrenia Research

      Volume: - Pages: 52-59

    • DOI

      10.1016/j.schres.2019.02.002

    • Related Report
      2018 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Role of FABP7 in tumor cell signaling2019

    • Author(s)
      Kagawa Yoshiteru、Umaru Banlanjo A.、Ariful Islam、Shil Subrata Kumar、Miyazaki Hirofumi、Yamamoto Yui、Ogata Masaki、Owada Yuji
    • Journal Title

      Advances in Biological Regulation

      Volume: 71 Pages: 206-218

    • DOI

      10.1016/j.jbior.2018.09.006

    • Related Report
      2018 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Optimization of fixative solution for retinal morphology: a comparison with Davidson’s fixative and other fixation solutions2018

    • Author(s)
      Tokuda Kazuhiro、Baron Byron、Kuramitsu Yasuhiro、Kitagawa Takao、Tokuda Nobuko、Morishige Naoyuki、Kobayashi Masaaki、Kimura Kazuhiro、Nakamura Kazuyuki、Sonoda Koh-Hei
    • Journal Title

      Japanese Journal of Ophthalmology

      Volume: 62 Issue: 4 Pages: 481-490

    • DOI

      10.1007/s10384-018-0592-7

    • Related Report
      2018 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Fatty acid binding protein 7 may be a marker and therapeutic targets in clear cell renal cell carcinoma2018

    • Author(s)
      Nagao Kazuhiro、Shinohara Nachi、Smit Frank、de Weijert Mirjam、Jannink Sander、Owada Yuji、Mulders Peter、Oosterwijk Egbert、Matsuyama Hideyasu
    • Journal Title

      BMC Cancer

      Volume: 18 Issue: 1 Pages: 1114-1114

    • DOI

      10.1186/s12885-018-5060-8

    • Related Report
      2018 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] FABP3 in the Anterior Cingulate Cortex Modulates the Methylation Status of the Glutamic Acid Decarboxylase67 Promoter Region2018

    • Author(s)
      Yamamoto Yui、Kida Hiroyuki、Kagawa Yoshiteru、Yasumoto Yuki、Miyazaki Hirofumi、Islam Ariful、Ogata Masaki、Yanagawa Yuchio、Mitsushima Dai、Fukunaga Kohji、Owada Yuji
    • Journal Title

      The Journal of Neuroscience

      Volume: 38 Issue: 49 Pages: 10411-10423

    • DOI

      10.1523/jneurosci.1285-18.2018

    • NAID

      130007813353

    • Related Report
      2018 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Down-regulation of fatty acid binding protein 7 (Fabp7) is a hallmark of the postpartum brain2018

    • Author(s)
      Driessen Terri M.、Zhao Changjiu、Saenz Marissa、Stevenson Sharon A.、Owada Yuji、Gammie Stephen C.
    • Journal Title

      Journal of Chemical Neuroanatomy

      Volume: 92 Pages: 92-101

    • DOI

      10.1016/j.jchemneu.2018.07.003

    • Related Report
      2018 Research-status Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Glial Fatty Acid-Binding Protein 7 (FABP7) Regulates Neuronal Leptin Sensitivity in the Hypothalamic Arcuate Nucleus2018

    • Author(s)
      Yasumoto Yuki、Miyazaki Hirofumi、Ogata Masaki、Kagawa Yoshiteru、Yamamoto Yui、Islam Ariful、Yamada Tetsuya、Katagiri Hideki、Owada Yuji
    • Journal Title

      Molecular Neurobiology

      Volume: - Issue: 12 Pages: 9016-9028

    • DOI

      10.1007/s12035-018-1033-9

    • Related Report
      2018 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Utility of Bartonella henselae IgM Western Blot Bands for Serodiagnosis of Cat Scratch Disease2017

    • Author(s)
      Otsuyama Ken-ichiro、Tsuneoka Hidehiro、Yoshidomi Hiroka、Haraguchi Mio、Yanagihara Masashi、Tokuda Nobuko、Nojima Junzo、Ichihara Kiyoshi
    • Journal Title

      Journal of Clinical Microbiology

      Volume: 56 Issue: 1 Pages: 1-6

    • DOI

      10.1128/jcm.01322-17

    • Related Report
      2017 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Ultrastructural histomeric evidence for expansion of sustentacular cell envelop in response to hypersecretion of adrenal chromaffin cells in mice.2017

    • Author(s)
      Pakkarato S, Thoungseabyoun W, Tachow A, Rawangwong A, Kagawa Y, Owada Y, Kondo H, Hipkaeo W.
    • Journal Title

      Anat Sci Int

      Volume: 印刷中 Issue: 1 Pages: 75-81

    • DOI

      10.1007/s12565-016-0370-x

    • Related Report
      2017 Research-status Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Dab1 contributes differently to the morphogenesis of the hippocampal subdivisions2017

    • Author(s)
      Blume Marissa、Inoguchi Fuduki、Sugiyama Taku、Owada Yuji、Osumi Noriko、Aimi Yoshinari、Taki Kosuke、Katsuyama Yu
    • Journal Title

      Development, Growth & Differentiation

      Volume: 59 Issue: 8 Pages: 657-673

    • DOI

      10.1111/dgd.12393

    • Related Report
      2017 Research-status Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Mitochonic Acid 5 (MA-5) Facilitates ATP Synthase Oligomerization and Cell Survival in Various Mitochondrial Diseases2017

    • Author(s)
      Tetsuro Matsuhashi, Takeya Sato,(間30名),Yuji Owada, 他9名
    • Journal Title

      EBioMedicine

      Volume: 20 Pages: 27

    • DOI

      10.1016/j.ebiom.2017.05.016

    • NAID

      120007134536

    • URL

      https://pure.teikyo.jp/en/publications/b6fee86c-4659-43f6-98ca-a57629957a0b

    • Related Report
      2017 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Retinoic acid regulates cell-shape and -death of E-FABP (FABP5)-immunoreactive septoclasts in the growth plate cartilage of mice2017

    • Author(s)
      Bando Y, Yamamoto M, Sakiyama K, Sakashita H, Taira F, Miyake G, Iseki S, Owada Y, Amano O
    • Journal Title

      Hsitochem. Cell Biol.

      Volume: 148(3) Issue: 3 Pages: 229-238

    • DOI

      10.1007/s00418-017-1578-0

    • Related Report
      2017 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Normal sleep requires the astrocyte brain-type fatty acid binding protein FABP72017

    • Author(s)
      Gerstner JR, Perron IJ, Riedy SM, Yoshikawa T, Kadotani H, Y Owada, van Dongen HPA, Galante RJ, Dickinson K, Yin JCP, Pack AI, Frank MG
    • Journal Title

      Science Advances

      Volume: 3 Issue: 4

    • DOI

      10.1126/sciadv.1602663

    • NAID

      120006539728

    • Related Report
      2017 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Epidural focal brain cooling abolishes neocortical seizures in cats and non-human primates2017

    • Author(s)
      Inoue Takao、Fujii Masami、Kida Hiroyuki、Yamakawa Toshitaka、Maruta Yuichi、Tokiwa Tatsuji、He Yeting、Nomura Sadahiro、Owada Yuji、Yamakawa Takeshi、Suzuki Michiyasu
    • Journal Title

      Neuroscience Research

      Volume: 122 Pages: 35-44

    • DOI

      10.1016/j.neures.2017.04.007

    • Related Report
      2017 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Dorsal Forebrain-Specific Deficiency of Reelin-Dab1 Signal Causes Behavioral Abnormalities Related to Psychiatric Disorders.2016

    • Author(s)
      Imai, H.;Shoji, H.;Ogata, M.;Kagawa, Y.;Owada, Y.;Miyakawa, T.;Sakimura, K.;Terashima, T.;Katsuyama, Y.
    • Journal Title

      Cereb Cortex

      Volume: - Issue: 7 Pages: 1-17

    • DOI

      10.1093/cercor/bhv334

    • Related Report
      2017 Research-status Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Presentation] 小腸特異的エクソソームの単離と分子解析2020

    • Author(s)
      上田祐司, 徳田信子
    • Organizer
      第125回 日本解剖学会学術集会(誌上開催)
    • Related Report
      2019 Annual Research Report
  • [Presentation] 悪性グリオーマでIDH遺伝子変異の有無とFABP7の発現・核局在は相関する2020

    • Author(s)
      香川慶輝, Umaru Banlanjo Abdulaziz, 大和田祐二
    • Organizer
      第125回日本解剖学会学術総会全国学術集会 (誌上開催)
    • Related Report
      2019 Annual Research Report
  • [Presentation] 接触性過敏症におけるFABP3の関与機構2020

    • Author(s)
      小林周平, 香川慶輝, 宮崎啓史, 大和田祐二
    • Organizer
      第125回日本解剖学会学術総会全国学術集会 (誌上開催)
    • Related Report
      2019 Annual Research Report
  • [Presentation] FABP7は細胞内脂質代謝制御を介してマクロファージの抗炎症性機能に関わる2020

    • Author(s)
      宮崎啓史, 香川慶輝, 小林周平, 大和田祐二
    • Organizer
      第125回日本解剖学会学術総会全国学術集会 (誌上開催)
    • Related Report
      2019 Annual Research Report
  • [Presentation] Ndufs4 loss results in glial activation in cerebral cortex and hippocampus.2020

    • Author(s)
      Shil Subrata, Yoshiteru Kagawa, Umaru Banlanjo Abdulaziz, Hirofumi Miyazaki, Yui Yamamoto, Takaaki Abe, Yuji Owada
    • Organizer
      第125回日本解剖学会学術総会全国学術集会 (誌上開催)
    • Related Report
      2019 Annual Research Report
  • [Presentation] Fatty acid binding protein 7 (FABP7)-Oleic acid interaction, a potent access promoting glioma cell proliferation.2020

    • Author(s)
      Umaru Banlanjo Abdulaziz, Yoshiteru Kagawa, Yuji Owada
    • Organizer
      第125回日本解剖学会学術総会全国学術集会 (誌上開催)
    • Related Report
      2019 Annual Research Report
  • [Presentation] 脂肪酸結合タンパク質3(FABP3)が前帯状皮質におけるパルブアルブミン発現とペリニューロナルネット形成に及ぼす影響2020

    • Author(s)
      山本由似, 尾形雅君, 上条桂樹, 大和田祐二
    • Organizer
      第125回日本解剖学会学術総会全国学術集会 (誌上開催)
    • Related Report
      2019 Annual Research Report
  • [Presentation] マウス小腸における腸上皮細胞間リンパ球(IEL)の役割: IELの活性化、死の転帰、そして再構築2020

    • Author(s)
      尾形雅君, 山本由似, 上条桂樹, 伊藤恒敏, 大和田祐二
    • Organizer
      第125回日本解剖学会学術総会全国学術集会 (誌上開催)
    • Related Report
      2019 Annual Research Report
  • [Presentation] パイエル板胚中心マクロファージの取り込み能における表皮型脂肪酸結合タンパク質の機能2020

    • Author(s)
      鈴木良地, 大和田祐二, 板東良雄
    • Organizer
      第125回日本解剖学会学術総会全国学術集会 (誌上開催)
    • Related Report
      2019 Annual Research Report
  • [Presentation] Alteration of parvalbumin expression and perineuronal nets formation in the anterior cingulate cortex of Fabp3 KO mice.2020

    • Author(s)
      山本由似, 福永浩司, 大和田祐二, 上条桂樹
    • Organizer
      第93回日本薬理学会年会(誌上開催)
    • Related Report
      2019 Annual Research Report
  • [Presentation] うつ病モデルラットにおける免疫器官の組織学的解析2019

    • Author(s)
      調 美奈, 上田 祐司, 沢登 祥史, 北沢 祐介, 徳田 信子
    • Organizer
      第47回 獨協医学会
    • Related Report
      2019 Annual Research Report
  • [Presentation] Novel DC targeting by allogenic T-cells for multifocal prophylactic antibody production2019

    • Author(s)
      Ueta H, Kitazawa Y, Sawanobori Y, Katakai T, Ueha S, Matsushima K, Tokuda N, Matsuno K
    • Organizer
      第48回日本免疫学会学術集会
    • Related Report
      2019 Annual Research Report
  • [Presentation] Medullary epithelium-free areas in the rat thymus: Unique functional compartment populated by a thymic DC subset and Foxp3+ cells.2019

    • Author(s)
      Yasushi Sawanobori, Hisashi Ueta, Yusuke Kitazawa, Kenjiro Matsuno, Nobuko Tokuda
    • Organizer
      第48回日本免疫学会学術集会
    • Related Report
      2019 Annual Research Report
  • [Presentation] FABP7によるacetyl-CoA代謝の制御機構2019

    • Author(s)
      香川慶輝, Banlanjo Abdulaziz Umaru, 大和田祐二
    • Organizer
      第42回日本分子生物学会年会
    • Related Report
      2019 Annual Research Report
  • [Presentation] FABP7による細胞内脂肪酸代謝とグリオーマ増殖の関連2019

    • Author(s)
      Banlanjo Abdulaziz Umaru, 香川慶輝, 大和田祐二
    • Organizer
      第42回日本分子生物学会年会
    • Related Report
      2019 Annual Research Report
  • [Presentation] Upregulating blood-brain barrier FABP5 as a novel way to resore DHA levels in Alzheimer's disease brain2019

    • Author(s)
      Yijun Pan, Yi Ling Low, Joseph Nicolazzo, Yuji Owada
    • Organizer
      11th Models of Physiology and Disease Symposium and 2019 International Perspectives on Geroscience Meeting
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 創傷治癒過程におけるTRAF5を介した形質細胞様樹状細胞(pDC)の関与2019

    • Author(s)
      小林周平, 宗孝紀, 石井直人, 大和田祐二
    • Organizer
      日本解剖学会 第65回東北・北海道連合支部学術集会
    • Related Report
      2019 Annual Research Report
  • [Presentation] 核内FABP7による核内アセチルCoA代謝の制御機構2019

    • Author(s)
      香川慶輝, 大和田祐二
    • Organizer
      日本解剖学会 第65回東北・北海道連合支部学術集会
    • Related Report
      2019 Annual Research Report
  • [Presentation] パルブアルブミン陽性介在ニューロンにおける脂肪酸結合タンパク質FABP3の機能解析2019

    • Author(s)
      山本由似, 上条桂樹, 大和田祐二
    • Organizer
      日本解剖学会 第65回東北・北海道連合支部学術集会
    • Related Report
      2019 Annual Research Report
  • [Presentation] The mechanism of epigenetic regulation by nuclear fatty acid binding protein 7 (FABP7)2019

    • Author(s)
      Yoshiteru Kagawa, Banlanjo A Umaru, Yuji Owada
    • Organizer
      60th International Conference on the Bioscience of Lipids
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Fatty acid binding protein 3 (FABP3) in the anterior cingulate cortex modulates the methylation status of the glutamic decarboxylase67 promoter region2019

    • Author(s)
      Yui Yamamoto, Yuji Owada
    • Organizer
      60th International Conference on the Bioscience of Lipids
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] The involvement of fatty acid binding protein 5 in the blood-brain barrier transport of docosahexaenoic acid and cognition2019

    • Author(s)
      Yijun Pan, Joseph Nicolazzo, Yuji Owada
    • Organizer
      60th International Conference on the Bioscience of Lipids
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Upregulating blood-brain barrier FABP5 as a novel way to restore DHA in AD brain2019

    • Author(s)
      Yijun Pan, Yi Ling Low, Joseph Nicolazzo, Yuji Owada
    • Organizer
      Australian Dementia Forum 19
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 再循環Tリンパ球による小腸の迅速な免疫監視:パイエル板の特殊性とその意義2019

    • Author(s)
      上田祐司、内田知見、沢登祥史、北沢祐介、松野健二郎、徳田信子
    • Organizer
      第43回日本リンパ学会総会
    • Related Report
      2018 Research-status Report
  • [Presentation] 免疫系微小環境解析によるドナー特異的輸血DSTの移植免疫寛容の機序解明とその臨床応用2019

    • Author(s)
      上田祐司、北沢祐介、沢登祥史、松野健二郎、徳田信子
    • Organizer
      第124回日本解剖学会学術総会全国学術集会
    • Related Report
      2018 Research-status Report
    • Invited
  • [Presentation] ドナーT細胞のXCR+樹状細胞による抗体産生応答2019

    • Author(s)
      北沢祐介、上田祐司、沢登祥史、松野健二郎、徳田信子
    • Organizer
      第124回日本解剖学会学術総会全国学術集会
    • Related Report
      2018 Research-status Report
  • [Presentation] うつ病モデルラットにおける免疫系微小構造の組織学的解析2019

    • Author(s)
      調美奈、上田祐司、北沢祐介、沢登祥史、徳田信子
    • Organizer
      第124回日本解剖学会学術総会全国学術集会
    • Related Report
      2018 Research-status Report
  • [Presentation] 骨吸収細胞septclastにおける脂肪酸結合タンパクの発現と役割2019

    • Author(s)
      板東康彦、坂下英、﨑山浩司、徳田信子、天野修
    • Organizer
      第124回日本解剖学会学術総会全国学術集会
    • Related Report
      2018 Research-status Report
  • [Presentation] 脂肪酸結合タンパク質を介した細胞内脂質環境の変化がエピゲノムに及ぼす影響2019

    • Author(s)
      山本由似, 大和田祐二
    • Organizer
      第124回日本解剖学会学術総会全国学術集会
    • Related Report
      2018 Research-status Report
    • Invited
  • [Presentation] 脂肪酸結合タンパク質FABP7とATP-citrate lyase (ACLY) の相互作用による核内Acetyl-CoAの量的調節機構2019

    • Author(s)
      香川慶輝, Umaru Banlanjo Abdulaziz, 大和田祐二
    • Organizer
      第124回日本解剖学会学術総会全国学術集会
    • Related Report
      2018 Research-status Report
  • [Presentation] ラット小腸における腸上皮細胞間リンパ節 (IEL) の役割:粘膜固有層マクロファージとの相互作用2019

    • Author(s)
      尾形雅君, 山本由似, 上条桂樹, 伊藤恒敏, 大和田祐二
    • Organizer
      第124回日本解剖学会学術総会全国学術集会
    • Related Report
      2018 Research-status Report
  • [Presentation] 脱髄疾患におけるアストロサイトの脂肪酸結合タンパク質FABP7の機能的役割の検討2019

    • Author(s)
      宮崎啓史, 神里賢勇, 佐藤匠, 香川慶輝, 大和田祐二
    • Organizer
      第124回日本解剖学会学術総会全国学術集会
    • Related Report
      2018 Research-status Report
  • [Presentation] Role of mitochondorial complex I and its subunit Ndufs4 in the regulation of glial and neuronal mitochondrial morphology and function2019

    • Author(s)
      Shil Subrata, Fumika Nanto, Hirofumi Miyazaki, Yoshiteru Kagawa, Yui Yamamoto, Yuji Owada
    • Organizer
      第124回日本解剖学会学術総会全国学術集会
    • Related Report
      2018 Research-status Report
  • [Presentation] Fatty acid binding protein 7 (FABP7) promotes glioma cell proliferation through modulation of Wnt/b-catenin signaling.2019

    • Author(s)
      Umaru Banlanjo Abdulaziz, Yoshiteru Kagawa, Yuji Owada
    • Organizer
      第124回日本解剖学会学術総会全国学術集会
    • Related Report
      2018 Research-status Report
  • [Presentation] パイエル板胚中心マクロファージにおける表皮型脂肪酸結合タンパク質の機能2019

    • Author(s)
      鈴木良地, 大和田祐二, 板東良雄
    • Organizer
      第124回日本解剖学会学術総会全国学術集会
    • Related Report
      2018 Research-status Report
  • [Presentation] FABP3 in the anterior cingulate cortex modulates the methylation status of the glutamic acid decarboxylase 67 promoter region2019

    • Author(s)
      山本由似, 大和田祐二, 福永浩司
    • Organizer
      第92回日本薬理学会年会
    • Related Report
      2018 Research-status Report
  • [Presentation] Attenuation and alteration of thymic epithelial cells and enhanced autoreactivity in cyclosporine A-treated rats.2018

    • Author(s)
      沢登祥史、上田祐司、北沢祐介、松野健二郎、徳田信子
    • Organizer
      第47回日本免疫学会学術集会
    • Related Report
      2018 Research-status Report
  • [Presentation] 細胞核内FABP7とATP citrate lyase (ACLY) の相互作用によるエピゲノム制御機構2018

    • Author(s)
      香川慶輝, 大和田祐二
    • Organizer
      第41回日本分子生物学会
    • Related Report
      2018 Research-status Report
  • [Presentation] Role of FABP7 in astrocytes and its possible association with psychiatric diseases.2018

    • Author(s)
      Yuji Owada
    • Organizer
      59th International Symposium on "Biological Regulation and Enzyme Activity in Normal and Neoplastic Tissues" Symposium "Signaling and Disease"
    • Related Report
      2018 Research-status Report
    • Int'l Joint Research / Invited
  • [Presentation] 脂肪酸結合タンパク質の細胞核局在がエピゲノム変化におよぼす影響2018

    • Author(s)
      香川慶輝, 大和田祐二
    • Organizer
      第59回日本組織細胞化学会総会
    • Related Report
      2018 Research-status Report
    • Invited
  • [Presentation] 脂肪酸結合タンパク質によるエピゲノム制御2018

    • Author(s)
      大和田祐二
    • Organizer
      第91回日本生化学会大会
    • Related Report
      2018 Research-status Report
    • Invited
  • [Presentation] 脂肪酸結合タンパク質(FABP)を通して精神疾患を理解する2018

    • Author(s)
      大和田祐二
    • Organizer
      第14回REDEEMシンポジウム
    • Related Report
      2018 Research-status Report
    • Invited
  • [Presentation] 脱髄疾患におけるFABP7の発現変化と病態生理への関与2018

    • Author(s)
      宮崎啓史, 神里賢勇, 佐藤匠, 大和田祐二
    • Organizer
      日本解剖学会 第64回東北・北海道連合支部学術集会
    • Related Report
      2018 Research-status Report
  • [Presentation] パイエル板胚中心における表皮型脂肪酸結合タンパク質の機能2018

    • Author(s)
      鈴木良地, 大和田祐二, 板東良雄
    • Organizer
      日本解剖学会 第64回東北・北海道連合支部学術集会
    • Related Report
      2018 Research-status Report
  • [Presentation] FABP3 in the anterior cingulate cortex mediates methylation status of gluatamic acid decarboxylase 67 promoter region.2018

    • Author(s)
      Yui Yamamoto, Hiroyuki Kida, Dai Mitsushma, Keiju Kamijo, Yuji Owada, Kohji Fukunaga
    • Organizer
      18th World Congress of Basic and Clinical Pharmacology
    • Related Report
      2018 Research-status Report
    • Int'l Joint Research
  • [Presentation] Fibroblastic reticular cells (FRC)におけるFABP7の局在と機能2018

    • Author(s)
      徳田信子, 山本由似, 児玉孝憲, 徳田和央, 木村和博, 坂東康彦, 天野修, 宮崎啓史, 大和田祐二
    • Organizer
      第123回日本解剖学会総会
    • Related Report
      2017 Research-status Report
  • [Presentation] アストロサイトにおける脂肪酸結合蛋白質FABP7の機能解析2018

    • Author(s)
      香川慶輝, 大和田祐二
    • Organizer
      第123回日本解剖学会総会
    • Related Report
      2017 Research-status Report
  • [Presentation] 脂肪酸結合蛋白質FABP3による介在ニューロンのエピゲノム調節機構2018

    • Author(s)
      山本由似, 木田裕之, 美津島大, 福永浩司, 尾形雅君, 上条桂樹, 大和田祐二
    • Organizer
      第123回日本解剖学会総会
    • Related Report
      2017 Research-status Report
  • [Presentation] FABP7 protects astrocyte against ROS toxicity under ROS stress2018

    • Author(s)
      Ariful Islam, Yoshiteru Kagawa, Hirofumi Miyazaki, Subrata Kumar Shil, Yuji Owada
    • Organizer
      第123回日本解剖学会総会
    • Related Report
      2017 Research-status Report
  • [Presentation] 腸上皮細胞間リンパ球の活性化に伴う小腸絨毛上皮細胞の剥離機構2018

    • Author(s)
      尾形雅君, 上条桂樹, 伊藤恒敏, 大和田祐二
    • Organizer
      第123回日本解剖学会総会
    • Related Report
      2017 Research-status Report
  • [Presentation] パイエル板表皮型脂肪酸結合タンパク質発現によるB細胞アポトーシス誘導2018

    • Author(s)
      鈴木良地, 大和田祐二, 阿部寛
    • Organizer
      第123回日本解剖学会総会
    • Related Report
      2017 Research-status Report
  • [Presentation] FABP5-KO マウスにおけるseptoclastの形態変化とPPARサブタイプの局在2018

    • Author(s)
      坂東康彦, 坂下英, 崎山浩司, 徳田信子, 大和田祐二, 天野修
    • Organizer
      第123回日本解剖学会総会
    • Related Report
      2017 Research-status Report
  • [Presentation] PACAP plays an essential role for neurogenesis and nerve regeneration after brain ischemia and spinal cord injury2017

    • Author(s)
      Seiji Shioda, Takahiro Hirabayashi, Fumiko Takenoya, Nobuhiro Wada, Nobuko Tokuda, Tomoya Nakamachi
    • Organizer
      13th International Symposium on VIP, PACAP and Related Peptides
    • Related Report
      2017 Research-status Report
    • Int'l Joint Research
  • [Presentation] FABP7 is involved in M2 polarization of macrophages via mitochondrial fatty-acid oxidation2017

    • Author(s)
      Hirofumi Miyazaki, Ai Shishido, Yoshiteru Kagawa, Yuki Yasumoto, Fumika Nannto, Yuji Owada
    • Organizer
      第46回日本免疫学会学術集会
    • Related Report
      2017 Research-status Report
  • [Presentation] FABP7は核内Acetyl-CoAレベル調節を介してエピジェネティックに遺伝子発現を制御する2017

    • Author(s)
      香川慶輝, 大和田祐二
    • Organizer
      第40回日本分子生物学会
    • Related Report
      2017 Research-status Report
  • [Presentation] マクロファージの抗炎症性機能分化における細胞内代謝の変化とFABP7の関与2017

    • Author(s)
      宮崎啓史, 宍戸愛, 香川慶輝, 安本有希, 南都文香, 大和田祐二
    • Organizer
      日本解剖学会 第63回東北・北海道連合支部学術集会
    • Related Report
      2017 Research-status Report
  • [Presentation] Role of FABP7 in astrocytes and its possible association with human psychiatric diseases2017

    • Author(s)
      Yuji Owada
    • Organizer
      Protein Misfolding Diseases and Therapy 2017
    • Related Report
      2017 Research-status Report
  • [Presentation] FABP3 in the anterior cingulate cortex mediates methylation status of GAD67 promotor region2017

    • Author(s)
      Yuji Owada, Yui Yamamoto, Hiroyuki Kida, Yuchio Yanagawa, Dai Mitsushima, Kohji Fukunaga
    • Organizer
      第40回日本神経科学大会
    • Related Report
      2017 Research-status Report
  • [Presentation] Abnormal neuronal activity in the basolateral amygdala mediates PTSD-like behaviors in FABP3 null mice2017

    • Author(s)
      Yasushi Yabuki, Ibuki Takahata, Yuji Owada, Kohji Fukunaga
    • Organizer
      第40回日本神経科学大会
    • Related Report
      2017 Research-status Report
  • [Presentation] 脂肪酸結合蛋白質FABP7によるヒストンアセチル化を介したcaveolin-1転写調節機構2017

    • Author(s)
      香川慶輝, 大和田祐二
    • Organizer
      第11回エピジェネティクス研究会年会
    • Related Report
      2017 Research-status Report
  • [Remarks]

    • URL

      http://macro.dokkyomed.ac.jp/index.html

    • Related Report
      2018 Research-status Report
  • [Remarks] 解剖学(マクロ)講座のホームページ

    • URL

      http://macro.dokkyomed.ac.jp/index.html

    • Related Report
      2017 Research-status Report

URL: 

Published: 2017-04-28   Modified: 2021-02-19  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi