• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

Evaluation of long-term nutritional status of geriatric patients using scalp hair components.

Research Project

Project/Area Number 17K00870
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Eating habits
Research InstitutionHealth Sciences University of Hokkaido

Principal Investigator

KIMURA Osamu  北海道医療大学, 薬学部, 講師 (10418882)

Project Period (FY) 2017-04-01 – 2020-03-31
Project Status Completed (Fiscal Year 2019)
Budget Amount *help
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2019: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2018: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2017: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
Keywords頭髪 / 炭素安定同位体 / 窒素安定同位体 / 経腸栄養 / 中心静脈栄養 / 高齢者 / 微量元素 / 安定同位体比 / 栄養 / 栄養学 / 安定同位体
Outline of Final Research Achievements

The stable isotope ratios (δ13C and δ15N) and trace elements in the scalp hair of patients who received enteral or parenteral nutrition were analyzed to assess long-term nutritional status of geriatric patients. The values of δ13C and δ15N in the scalp hair of geriatric patients ingesting enteral nutrition for long period may be good indicators to estimate nutritional status of patients. The duration of parenteral nutrition can be estimated by the δ13C and δ15N levels in the scalp hair of geriatric patients who are nutritionally controlled by parenteral nutrition. Deficiency and excess of trace elements could be estimated by the concentration of trace elements in the patient’s scalp hair.

Academic Significance and Societal Importance of the Research Achievements

臨床検査の多くは血液を用いているが、得られるデータのほとんどは採血時のものである。一方、頭髪は1ヶ月に約1cmずつ伸長するので、頭髪からは経時的かつ長期間の情報を得ることが可能である。頭髪は、経腸栄養や中心静脈栄養により長期間栄養管理を受けている患者、また糖尿病、高血圧、腎疾患などの慢性疾患をもつ患者の栄養評価に適した生体試料である。本研究では、高齢者の頭髪に含まれる炭素と窒素の安定同位体比および微量元素を測定することにより、高齢者の長期栄養状態の評価を試みた。

Report

(4 results)
  • 2019 Annual Research Report   Final Research Report ( PDF )
  • 2018 Research-status Report
  • 2017 Research-status Report
  • Research Products

    (9 results)

All 2020 2019 2018 2017

All Journal Article (5 results) (of which Int'l Joint Research: 1 results,  Peer Reviewed: 5 results) Presentation (4 results)

  • [Journal Article] Assessment of diabetics by the quantification of essential elements and stable isotope ratios of carbon and nitrogen in scalp hair2019

    • Author(s)
      Hotta Yohei、Fujino Ryoji、Kimura Osamu、Fujii Yukiko、Haraguchi Koichi、Endo Tetsuya
    • Journal Title

      Obesity Medicine

      Volume: 印刷中 Pages: 100106-100106

    • DOI

      10.1016/j.obmed.2019.100106

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Essential and Non-essential Elements in Scalp Hair of Diabetics: Correlations with Glycated Hemoglobin (HbA1c)2018

    • Author(s)
      Hotta Yohei、Fujino Ryoji、Kimura Osamu、Endo Tetsuya
    • Journal Title

      Biological and Pharmaceutical Bulletin

      Volume: 41 Issue: 7 Pages: 1034-1039

    • DOI

      10.1248/bpb.b18-00029

    • NAID

      130007387184

    • ISSN
      0918-6158, 1347-5215
    • Year and Date
      2018-07-01
    • Related Report
      2018 Research-status Report
    • Peer Reviewed
  • [Journal Article] Stable isotope ratios of carbon, nitrogen and selenium concentration in the scalp hair of Crohn's disease patients who ingested the elemental diet Elental ?2018

    • Author(s)
      Ogasawara Hideki、Hayasaka Moriaki、Maemoto Atsuo、Furukawa Shigeru、Ito Takahiro、Kimura Osamu、Endo Tetsuya
    • Journal Title

      Rapid Communications in Mass Spectrometry

      Volume: 33 Issue: 1 Pages: 41-48

    • DOI

      10.1002/rcm.8296

    • Related Report
      2018 Research-status Report
    • Peer Reviewed
  • [Journal Article] Nutritional assessment using stable isotope ratios of carbon and nitrogen in the scalp hair of geriatric patients who received enteral and parenteral nutrition formulas2017

    • Author(s)
      Hayasaka, M., Ogasawara, H., Hotta, Y., Tsukagoshi, K., Kimura, O., Kura, T., Tarumi, T., Muramatsu, H., and Endo, T.
    • Journal Title

      Clin. Nutr.

      Volume: 36 Issue: 6 Pages: 1661-1668

    • DOI

      10.1016/j.clnu.2016.10.017

    • Related Report
      2017 Research-status Report
    • Peer Reviewed
  • [Journal Article] Correlation between mercury concentration, and stable isotope ratios of carbon and nitrogen of amino acids in scalp hair from whale meat eaters and heavy fisheaters.2017

    • Author(s)
      Endo, T., Hayasaka, M., Ogasawara, H., Hotta, Y., Kimura, O., Petzke, K,J.
    • Journal Title

      Rapid Commun. Mass Spectrom

      Volume: 31 Issue: 9 Pages: 745-752

    • DOI

      10.1002/rcm.7841

    • Related Report
      2017 Research-status Report
    • Peer Reviewed / Int'l Joint Research
  • [Presentation] 中心静脈栄養輸液管理を受けた高齢者の頭髪中炭素および窒素安定同位体比と微量元素濃度2020

    • Author(s)
      木村 治、堀田洋平、垂水隆志、五十君篤哉、早坂敬明、浜上尚也、遠藤哲也
    • Organizer
      日本薬学会第140年会
    • Related Report
      2019 Annual Research Report
  • [Presentation] 中心静脈栄養輸液製剤により長期間栄養管理を受けた高齢者の頭髪中炭素・窒素の安定同位体比の変化2019

    • Author(s)
      木村 治、堀田洋平、垂水隆志、五十君篤哉、浅沼真介、早坂敬明、村松博士、浜上尚也、遠藤哲也
    • Organizer
      第3回日本老年薬学会学術大会
    • Related Report
      2019 Annual Research Report
  • [Presentation] 長期静脈栄養管理によるセレン欠乏の1例報告 患者頭髪中の微量元素と炭素および窒素安定同位体の分析について2017

    • Author(s)
      藤野陵二、村松博士、木村 治、佐藤英二、遠藤哲也
    • Organizer
      第27回日本医療薬学会
    • Related Report
      2017 Research-status Report
  • [Presentation] 成分栄養剤服用による頭髪中窒素・安定同位体比とセレンの変化について2017

    • Author(s)
      小笠原英樹、井上純孝、木村 治、遠藤哲也
    • Organizer
      第27回日本医療薬学会
    • Related Report
      2017 Research-status Report

URL: 

Published: 2017-04-28   Modified: 2021-02-19  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi