Evaluation of long-term nutritional status of geriatric patients using scalp hair components.

• Project/Area Number: 17K00870
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Eating habits
• Research Institution: Health Sciences University of Hokkaido
• Principal Investigator: KIMURA Osamu 北海道医療大学, 薬学部, 講師 (10418882)
• Project Period (FY): 2017-04-01 – 2020-03-31
• Project Status: Completed (Fiscal Year 2019)
• Budget Amount: ¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000); Fiscal Year 2019: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000); Fiscal Year 2018: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000); Fiscal Year 2017: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
• Keywords: 頭髪 / 炭素安定同位体 / 窒素安定同位体 / 経腸栄養 / 中心静脈栄養 / 高齢者 / 微量元素 / 安定同位体比 / 栄養 / 栄養学 / 安定同位体

Outline of Final Research Achievements

The stable isotope ratios (δ13C and δ15N) and trace elements in the scalp hair of patients who received enteral or parenteral nutrition were analyzed to assess long-term nutritional status of geriatric patients. The values of δ13C and δ15N in the scalp hair of geriatric patients ingesting enteral nutrition for long period may be good indicators to estimate nutritional status of patients. The duration of parenteral nutrition can be estimated by the δ13C and δ15N levels in the scalp hair of geriatric patients who are nutritionally controlled by parenteral nutrition. Deficiency and excess of trace elements could be estimated by the concentration of trace elements in the patient’s scalp hair.

Academic Significance and Societal Importance of the Research Achievements

臨床検査の多くは血液を用いているが、得られるデータのほとんどは採血時のものである。一方、頭髪は１ヶ月に約１cmずつ伸長するので、頭髪からは経時的かつ長期間の情報を得ることが可能である。頭髪は、経腸栄養や中心静脈栄養により長期間栄養管理を受けている患者、また糖尿病、高血圧、腎疾患などの慢性疾患をもつ患者の栄養評価に適した生体試料である。本研究では、高齢者の頭髪に含まれる炭素と窒素の安定同位体比および微量元素を測定することにより、高齢者の長期栄養状態の評価を試みた。

Research Products

• [Journal Article] Assessment of diabetics by the quantification of essential elements and stable isotope ratios of carbon and nitrogen in scalp hair (2019)
  • Author(s): Hotta Yohei、Fujino Ryoji、Kimura Osamu、Fujii Yukiko、Haraguchi Koichi、Endo Tetsuya
  • Journal Title: Obesity Medicine Volume: 印刷中 Pages: 100106-100106
  • DOI: 10.1016/j.obmed.2019.100106
  • Peer Reviewed
• [Journal Article] Essential and Non-essential Elements in Scalp Hair of Diabetics: Correlations with Glycated Hemoglobin (HbA1c) (2018)
  • Author(s): Hotta Yohei、Fujino Ryoji、Kimura Osamu、Endo Tetsuya
  • Journal Title: Biological and Pharmaceutical Bulletin Volume: 41 Issue: 7 Pages: 1034-1039
  • DOI: 10.1248/bpb.b18-00029
  • NAID: 130007387184
  • ISSN: 0918-6158, 1347-5215
  • Year and Date: 2018-07-01
  • Peer Reviewed
• [Journal Article] Stable isotope ratios of carbon, nitrogen and selenium concentration in the scalp hair of Crohn's disease patients who ingested the elemental diet Elental ? (2018)
  • Author(s): Ogasawara Hideki、Hayasaka Moriaki、Maemoto Atsuo、Furukawa Shigeru、Ito Takahiro、Kimura Osamu、Endo Tetsuya
  • Journal Title: Rapid Communications in Mass Spectrometry Volume: 33 Issue: 1 Pages: 41-48
  • DOI: 10.1002/rcm.8296
  • Peer Reviewed
• [Journal Article] Nutritional assessment using stable isotope ratios of carbon and nitrogen in the scalp hair of geriatric patients who received enteral and parenteral nutrition formulas (2017)
  • Author(s): Hayasaka, M., Ogasawara, H., Hotta, Y., Tsukagoshi, K., Kimura, O., Kura, T., Tarumi, T., Muramatsu, H., and Endo, T.
  • Journal Title: Clin. Nutr. Volume: 36 Issue: 6 Pages: 1661-1668
  • DOI: 10.1016/j.clnu.2016.10.017
  • Peer Reviewed
• [Journal Article] Correlation between mercury concentration, and stable isotope ratios of carbon and nitrogen of amino acids in scalp hair from whale meat eaters and heavy fisheaters. (2017)
  • Author(s): Endo, T., Hayasaka, M., Ogasawara, H., Hotta, Y., Kimura, O., Petzke, K,J.
  • Journal Title: Rapid Commun. Mass Spectrom Volume: 31 Issue: 9 Pages: 745-752
  • DOI: 10.1002/rcm.7841
  • Peer Reviewed / Int'l Joint Research
• [Presentation] 中心静脈栄養輸液管理を受けた高齢者の頭髪中炭素および窒素安定同位体比と微量元素濃度 (2020)
  • Author(s): 木村 治、堀田洋平、垂水隆志、五十君篤哉、早坂敬明、浜上尚也、遠藤哲也
  • Organizer: 日本薬学会第140年会
• [Presentation] 中心静脈栄養輸液製剤により長期間栄養管理を受けた高齢者の頭髪中炭素・窒素の安定同位体比の変化 (2019)
  • Author(s): 木村 治、堀田洋平、垂水隆志、五十君篤哉、浅沼真介、早坂敬明、村松博士、浜上尚也、遠藤哲也
  • Organizer: 第３回日本老年薬学会学術大会
• [Presentation] 長期静脈栄養管理によるセレン欠乏の１例報告 患者頭髪中の微量元素と炭素および窒素安定同位体の分析について (2017)
  • Author(s): 藤野陵二、村松博士、木村 治、佐藤英二、遠藤哲也
  • Organizer: 第27回日本医療薬学会
• [Presentation] 成分栄養剤服用による頭髪中窒素・安定同位体比とセレンの変化について (2017)
  • Author(s): 小笠原英樹、井上純孝、木村 治、遠藤哲也
  • Organizer: 第27回日本医療薬学会