| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2019: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2018: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2017: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
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| Outline of Final Research Achievements |
Psoriasis is a disorder of unknown cause in which chronic dermatitis is disabling and persistent, and is complicated by arthritis with joint destruction in about 10% of patients. It is also prone to comorbidity with metabolic syndrome and cardiovascular The life expectancy is shortened by 6 years due to the cardiovascular disorder. Fatty acid-binding protein (FABP) is responsible for intracellular fatty acid transport and is closely associated with a variety of systemic diseases. The applicant extracted RNA from whole skin layers of psoriasis patients to examine gene expression of subclasses of FABP and to study the localization of FABP in the patients' skin. In a preliminary study, a subclass of FABPs that was highly expressed by comprehensive gene expression analysis was methylated in all psoriasis patients and unmethylated in the target group, suggesting a link to the pathogenesis of psoriasis.
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