| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2019: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2018: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2017: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Outline of Final Research Achievements |
The pathogenic mechanism of renal angiopathy in prostacyclin (PGI2) deficient mice is unclear. In this study, we aimed to clarify the onset time and signal transduction pathway of renal disorder using PGI2 synthase gene-modified mice. In addition, the relationship with adipose tissue was examined using cultured adipocytes. It was revealed that PGI2 deficiency increased the expression of inflammatory cytokines in renal tissue by 28 days after birth. It was also suggested that the signal transduction system via PGI2-PPAR-delta may be important for the maintenance of renal function. The increased expression of inflammatory adipocytokines in adipocytes due to inflammation was suppressed by n-3 polyunsaturated fatty acids, and it was expected that the onset of renal vascular disorders could be prevented.
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