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The Relationship between Low Vitamin D Status and Hypertension/Cardiovascular Disease in Japanese: Epidemiological and Basic Approaches

Research Project

Project/Area Number 17K00895
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Eating habits
Research InstitutionOsaka Shoin Women's University

Principal Investigator

Tsugawa Naoko  大阪樟蔭女子大学, 健康栄養学部, 教授 (30207352)

Project Period (FY) 2017-04-01 – 2020-03-31
Project Status Completed (Fiscal Year 2019)
Budget Amount *help
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2019: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2018: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2017: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
KeywordsビタミンD / 25-ヒドロキシビタミンD / 血圧 / 副甲状腺ホルモン / ビタミンD / 25-ヒドロキシビタミンD / 心血管疾患 / ストレス / 栄養学 / ビタミン
Outline of Final Research Achievements

In cross sectional study of elderly women, low serum 25-hydroxyvitamin D (25OHD) concentration were detected as siginificant factors for elevation of blood pressure independent of age, BMI, serum PTH concentration, and eGFR by multiple regression analysis. On the other hand, we could not find no direct relationship between serum 25OHD concentration and blood pressure in the subjects including young generation.
In basic study, blood pressure of vitamin D receptor gene knockout mice (VDRKO) was significantly higher than that of wild type. We confirmed that vitamin D was a negative regulator of renal Renin gene expression independent of serum Ca concentration, and increase of renal epithelial sodium channel (ENaC) gene expression would contribute to increase of blood pressure in VDRKO.

Academic Significance and Societal Importance of the Research Achievements

国民の収縮期血圧水準が平均2mmHg低下すれば、心血管疾患は約5%、脳卒中罹患率は約6%減少すると推計されている。ビタミンDと血圧・心血管疾患の関連については幾つか報告があるが、そのほとんどは欧米人を対象としたものである。欧米人と日本人では食生活、体格、遺伝的要因も大きく異なり、そのまま日本人に当てはめることはできない。本研究の第一の意義は日本人を対象としてビタミンDと血圧・心血管疾患の関連を調査したことにあり、実験動物を用いた基礎研究結果を合わせたデータは日本人のビタミンD栄養改善を進める上で重要な意義を持つ。

Report

(4 results)
  • 2019 Annual Research Report   Final Research Report ( PDF )
  • 2018 Research-status Report
  • 2017 Research-status Report
  • Research Products

    (19 results)

All 2019 2018 2017

All Journal Article (7 results) (of which Int'l Joint Research: 1 results,  Peer Reviewed: 7 results,  Open Access: 6 results) Presentation (12 results) (of which Int'l Joint Research: 2 results,  Invited: 3 results)

  • [Journal Article] 25-Hydroxyvitamin D profiles and maternal bone mass during pregnancy and lactation in Japanese women2019

    • Author(s)
      Yoshikata Hiromi、Tsugawa Naoko、Watanabe Yuna、Tsuburai Taku、Chaki Osamu、Hirahara Fumiki、Miyagi Etsuko、Sakakibara Hideya、Uenishi Kazuhiro、Okano Toshio
    • Journal Title

      Journal of Bone and Mineral Metabolism

      Volume: 38 Issue: 1 Pages: 99-108

    • DOI

      10.1007/s00774-019-01032-w

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] A simple questionnaire for the prediction of vitamin D deficiency in Japanese adults (Vitaimn D Deficiency questionnaire for Japanese: VDDQ-J).2019

    • Author(s)
      Kuwabara A, Tsugawa N, Mizuno K, Ogasawara H, Watanabe Y, Tanaka K
    • Journal Title

      J Bone Miner Metab

      Volume: ー Issue: 5 Pages: 854-863

    • DOI

      10.1007/s00774-018-0984-2

    • NAID

      130007882286

    • Related Report
      2019 Annual Research Report 2018 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Generation of 1,25-dihydroxyvitamin D3 in Cyp27b1 knockout mice by treatment with 25-hydroxyvitamin D3 rescued their rachitic phenotypes.2019

    • Author(s)
      Nishikawa M, Yasuda K, Takamatsu M, Abe K, Nakagawa K, Tsugawa N, Hirota Y, Tanaka K, Yamashita S, Ikushiro S, Suda T, Okano T, Sakaki T
    • Journal Title

      J Steroid Biochem Mol Biol.

      Volume: 185 Pages: 71-79

    • DOI

      10.1016/j.jsbmb.2018.07.012

    • Related Report
      2019 Annual Research Report 2018 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Significance of urinary C-megalin excretion in vitamin D metabolism in pre-dialysis CKD patients.2019

    • Author(s)
      Toi N, Inaba M, Ishimura E, Tsugawa N, Imanishi Y, Emoto M, Hirayama Y, Nakatani S, Saito A, Yamada S
    • Journal Title

      Science reports

      Volume: 9 Issue: 1 Pages: 2207-2207

    • DOI

      10.1038/s41598-019-38613-8

    • Related Report
      2019 Annual Research Report 2018 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Optimal vitamin D intake for preventing serum 25-hydroxyvitamin D insufficiency in young Japanese women.2018

    • Author(s)
      Ohta H, Kuroda T, Tsugawa N, Onoe Y, Okano T, Shiraki M
    • Journal Title

      J Bone Miner Metab

      Volume: 36 Issue: 5 Pages: 620-625

    • DOI

      10.1007/s00774-017-0879-7

    • Related Report
      2018 Research-status Report 2017 Research-status Report
    • Peer Reviewed
  • [Journal Article] Surveillance evaluation of the standardization of assay values for serum total 25-hydroxyvitamin D concentration in Japan.2018

    • Author(s)
      Ihara H, Kiuchi S, Ishige T, Nishimura M, Matsushita K, Satoh M, Nomura F, Yamashita M, Kitajima I, Tsugawa N, Okano T, Hirota K, Miura M, Totani M, Hashizume N; Nutrition Division, Japan Society of Clinical Chemistry.
    • Journal Title

      Ann Clin Biochem.

      Volume: Epub ahead of print Issue: 6 Pages: 0-0

    • DOI

      10.1177/0004563218765570

    • Related Report
      2018 Research-status Report 2017 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Nongenomic effects of 1α,25-dihydroxyvitamin D3 on cartilage formation deduced from comparisons between Cyp27b1 and Vdr knockout mice2017

    • Author(s)
      Y Hirota K Nakagawa S Mimatsu N Sawada T Sakaki N Kubodera M Kamao N Tsugawa Y Suhara T Okano
    • Journal Title

      Biochemical and Biophysical Research Communications

      Volume: 483 Issue: 1 Pages: 359-365

    • DOI

      10.1016/j.bbrc.2016.12.139

    • Related Report
      2017 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Presentation] ビタミンD, K摂取の現状と課題2019

    • Author(s)
      津川尚子
    • Organizer
      日本ビタミン学会第71回大会
    • Related Report
      2019 Annual Research Report
    • Invited
  • [Presentation] 血中25-hydroxyvitamin D3濃度に対するカルシウム摂取量の影響ならびにvitamin D3および25-hydroxyvitamin D3の補給効果の検討2019

    • Author(s)
      小笠原帆南、石野穂乃果、井ノ倉里菜、岡田真由子、中谷友香、鎌尾まや、津川尚子
    • Organizer
      日本ビタミン学会第71回大会
    • Related Report
      2019 Annual Research Report
  • [Presentation] 日本人健常成人を対象とした健康計測におけるビタミンD栄養調査2019

    • Author(s)
      津川尚子、桒原晶子、浦千尋、小笠原帆南、水野敬、渡辺恭良、田中清
    • Organizer
      第21回日本骨粗鬆症学会
    • Related Report
      2019 Annual Research Report 2018 Research-status Report
  • [Presentation] ビタミンD欠乏判定簡易質問票(Vitamin D deficiency questionnaire for Japanese: VDDQ-J)の妥当性および下肢筋力との関連性の検討2019

    • Author(s)
      桒原晶子、津川尚子、水野敬、小笠原帆南、中津由香、渡辺恭良、田中清
    • Organizer
      第21回日本骨粗鬆症学会
    • Related Report
      2019 Annual Research Report
  • [Presentation] 教育講演:日本人のビタミンD栄養の現状と骨および筋肉における役割2019

    • Author(s)
      津川尚子
    • Organizer
      日本スポーツ栄養学会第6回大会
    • Related Report
      2019 Annual Research Report
    • Invited
  • [Presentation] 高齢化社会におけるビタミン・バイオファクター 摂取の現状と問題点 「ビタミンD不足と健康影響:栄養改善へ向けた取り組み」2019

    • Author(s)
      津川尚子
    • Organizer
      フォーラム2019 衛生薬学・環境トキシコロジー
    • Related Report
      2019 Annual Research Report
    • Invited
  • [Presentation] Comparison of breast milk vitamin D and 25-hydroxyvitamin D concentration of Japanese breastfeeding women in 1989 and 2016-20172019

    • Author(s)
      Nishino Mayu、Kuwabara Akiko、Ogasawara Honami、Kamao Maya、Kobayashi Syunjiro、Yamamura Juniichi、Tsugawa Naoko
    • Organizer
      Internattional Conference on Food Factors: ICoFF 2019
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Cross-sectional survey for vitamin D status of healthy Japanese adults in the health life research complex program2019

    • Author(s)
      Tsugawa Naoko, Kuwabara Akiko, Ura Chihiro, Ogasawara Honami, Mizuno Kei, Watanabe Yasuyoshi, Tanaka Kiyoshi
    • Organizer
      Internattional Conference on Food Factors: ICoFF 2019
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 血中25-hydroxyvitamin D3濃度に対するカルシウム摂取量の影響ならびにvitamin D3および25-hydroxyvitamin D3の補給効果の検討2019

    • Author(s)
      小笠原帆南、石野穂乃果、井ノ倉里菜、岡田真由子、中谷友香、鎌尾まや 、津川尚子
    • Organizer
      日本ビタミン学会第71回大会
    • Related Report
      2018 Research-status Report
  • [Presentation] 若齢ラットの血中25-Hydroxyvitamin D3濃度に対するvitamin D3および25-hydroxyvitamin D3の補給効果ならびにカルシウム摂取量の影響2018

    • Author(s)
      津川尚子、小笠原帆南、堤彩香、中塚はつき、吉田みのり、鎌尾まや
    • Organizer
      日本ビタミン学会第70回大会
    • Related Report
      2018 Research-status Report 2017 Research-status Report
  • [Presentation] 若年成人女性のビタミンD栄養とライフスタイルの年間実態調査2017

    • Author(s)
      小笠原帆南、桒原晶子、尾坂郁恵 、小野智子、鎌尾まや、中川公恵、長谷川 潤、田中 清、津川尚子
    • Organizer
      日本ビタミン学会第69回大会
    • Related Report
      2017 Research-status Report
  • [Presentation] 若年成人女性におけるビタミンD栄養とライフスタイルの年間調査ならびにビタミンD栄養改善に対する意識調査2017

    • Author(s)
      津川尚子、桒原晶子、小笠原帆南、中川公恵、長谷川 潤、田中 清
    • Organizer
      第19回日本骨粗鬆症学会
    • Related Report
      2017 Research-status Report

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Published: 2017-04-28   Modified: 2021-02-19  

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