| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2019: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2018: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2017: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Outline of Final Research Achievements |
To study the contribution of sympathetic nerve activity (SNA) to the process of low sodium intake, experiments were designed to continuously and simultaneously measure renal (RSNA) and lumbar SNA during the development of hypertension induced by 8% salt loading and then returned to a normal diet to low sodium diet in Dahl salt-sensitive rats. Mean arterial pressure (MAP) significantly increased during 2 weeks of salt loading. However, the sympathetic nerve activity did not increase. After to the process of low sodium intake, MAP returned to the pre-salt loading level, but RSNA was significantly increased by 32 ± 3%. It was suggested that RSNA activity is hypersensitive to salt loss.
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