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Preventive effect of polyphenols intake during lactation on the obesity-related inflammation in high-fat-diet fed rat offspring exposed to maternal malnutrition

Research Project

Project/Area Number 17K00922
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Eating habits
Research InstitutionAomori University of Health and Welfare

Principal Investigator

SATO Shin  青森県立保健大学, 健康科学部, 教授 (40310099)

Co-Investigator(Kenkyū-buntansha) 向井 友花  神奈川県立保健福祉大学, 保健福祉学部, 准教授 (60331211)
乗鞍 敏夫  青森県立保健大学, 健康科学部, 講師 (40468111)
Project Period (FY) 2017-04-01 – 2020-03-31
Project Status Completed (Fiscal Year 2019)
Budget Amount *help
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2019: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2018: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2017: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Keywords:妊娠期授乳期低栄養 / 肥満 / 慢性炎症 / マクロファージ / オートファジー / ケルセチン / 胎生期低栄養 / 炎症細胞 / 線維化 / 骨格筋 / 炎症性サイトカイン / 脂質代謝 / DNAメチル基転移酵素 / 茶カテキン / 栄養学 / 食品 / 脂質 / 生理活性
Outline of Final Research Achievements

Maternal undernutrition is known to increase the risk of obesity and kidney diseases in offspring. We investigated whether Quercetin (Q), a flavonoid compound, intake during lactation could modulate inflammation and autophagy flux in the kidneys of high-fructose-diet (HFD)-fed adult female offspring from dams fed on normal- or low-protein diets during pregnancy and lactation. When Q was given during lactation, the increased macrophages infiltration and upregulated IL-6 mRNA levels were attenuated in the kidneys of HFD-fed adult female offspring exposed to maternal normal- or low-protein diets. In addition, Q intake upregulated the autophagy flux, LC3B-II levels, in the kidneys. Therefore, Q intake during lactation may cause long-term alterations in inflammation and autophagy flux in the kidneys of HFD-fed adult female offspring. Q intake during lactation could be a useful preventive strategy for HFD-related kidney diseases in adult female offspring.

Academic Significance and Societal Importance of the Research Achievements

本研究の学術的意義は、妊娠期及び授乳期に低栄養に曝された母ラットの授乳期にケルセチンを投与すると、ケルセチンは離乳後に果糖を負荷した雌性仔ラットの腎臓に生じる慢性炎症を軽減したり、低下したオートファジー活性を増加したりするという事実を見出した点にある。これは、これまでになかったケルセチンの新しい生理機能といえる。また、授乳期に摂取するケルセチンは、胎生期や乳児期の低栄養に起因する児の、成長後の果糖負荷によって生じる腎臓病等を軽減することが示唆される。本研究の社会的意義は、本研究の成果が早期医療・早期介入とする「先制医療」を見据えた新しい予防方策に寄与するという点にある。

Report

(4 results)
  • 2019 Annual Research Report   Final Research Report ( PDF )
  • 2018 Research-status Report
  • 2017 Research-status Report
  • Research Products

    (24 results)

All 2020 2019 2018 2017

All Journal Article (10 results) (of which Int'l Joint Research: 1 results,  Peer Reviewed: 9 results,  Open Access: 2 results) Presentation (14 results)

  • [Journal Article] Lignin-derived low-molecular-weight oxidized lignophenol stimulates AMP-activated protein kinase and suppresses renal inflammation and interstitial fibrosis in high fat diet-fed mice2020

    • Author(s)
      Sato Shin、Norikura Toshio、Mukai Yuuka、Yamaoka Shin、Mikame Keigo
    • Journal Title

      Chemico-Biological Interactions

      Volume: 318 Pages: 108977-108977

    • DOI

      10.1016/j.cbi.2020.108977

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] cis-Banglene, a bangle (Zingiber purpureum)-derived bioactive compound, promotes mitochondrial biogenesis and glucose uptake by activating the IL-6/AMPK signaling pathway in C2C12 skeletal muscle cells.2020

    • Author(s)
      Norikura T, Kajiya S, Sugawara M, Kubo M, Fukuyama Y, Sato S.
    • Journal Title

      Journal of Functional Foods

      Volume: 64 Pages: 103632-103632

    • DOI

      10.1016/j.jff.2019.103632

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Long-term effects of maternal resveratrol intake during lactation on cholesterol metabolism in male rat offspring.2020

    • Author(s)
      Yamasaki S, Tomihara T, Kimura G, Ueno Y, Ketema RM, Sato S, Mukai Y, Sikder T, Kurasaki M, Hosokawa T, Saito T.
    • Journal Title

      International Journal of Food Sciences and Nutrition.

      Volume: 71 Issue: 2 Pages: 226-234

    • DOI

      10.1080/09637486.2019.1639638

    • NAID

      120006869880

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Maternal quercetin intake during lactation attenuates renal inflammation and modulates autophagy flux in high-fructose-diet-fed female rat offspring exposed to maternal malnutrition.2019

    • Author(s)
      Sato S, Norikura T, Mukai Y.
    • Journal Title

      Food & Function

      Volume: 10 Issue: 8 Pages: 5018-5031

    • DOI

      10.1039/c9fo01134j

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Polyphenol-enriched azuki bean (Vina angularis) extract reduces the oxidative stress and prevents DNA oxidation in the hearts of streptozotocin-induced early diabetic rats2019

    • Author(s)
      Kita-Tomihara T, Sato S, Yamasaki S, Ueno Y, Kimura G, Ketema RM, Kawahara T, Kurasaki M, Saito T
    • Journal Title

      International Journal of Food Sciences and Nutrition

      Volume: 70 Issue: 7 Pages: 1-11

    • DOI

      10.1080/09637486.2019.1576598

    • Related Report
      2018 Research-status Report
    • Peer Reviewed
  • [Journal Article] Sorghum (Sorghum bicolor) Extract Affects Plasma Lipid Metabolism and Hepatic Macrophage Infiltration in Diabetic Rats2019

    • Author(s)
      Mukai Y, Kataoka S, Sato S
    • Journal Title

      Current Nutrition & Food Science

      Volume: 15 Issue: 5 Pages: 1-9

    • DOI

      10.2174/1573401315666190114153933

    • Related Report
      2018 Research-status Report
    • Peer Reviewed
  • [Journal Article] Effect of Bangle (Zingiber purpureum) extract and low-intensity exercise on mTOR phosphorylation and autophagy flux in skeletal muscles of rats on a high-fat diet.2018

    • Author(s)
      Sato S, Kataoka S, Sato M, Takahashi A, Norikura T, Mukai Y
    • Journal Title

      Journal of Functional Foods

      Volume: 47 Pages: 554-561

    • DOI

      10.1016/j.jff.2018.06.010

    • Related Report
      2018 Research-status Report
    • Peer Reviewed
  • [Journal Article] 臨床医として知っておきたいミネラルの知識、「銅」2018

    • Author(s)
      佐藤 伸
    • Journal Title

      成人病と生活習慣病

      Volume: 48 Pages: 659-663

    • Related Report
      2018 Research-status Report
  • [Journal Article] Melinjo (Gnetum gnemon) seed extract consumption during lactation improved vasodilation and attenuated the development of hypertension in female offspring of fructose-fed pregnant rats.2018

    • Author(s)
      Uson-Lopez RA, Kataoka S, Mukai Y, Sato S, Kurasaki M
    • Journal Title

      Birth Defects Research.

      Volume: 110 Issue: 1 Pages: 27-34

    • DOI

      10.1002/bdr2.1109

    • Related Report
      2017 Research-status Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Maternal green tea polyphenol intake during lactation attenuates kidney injury in high-fat diet-fed male offspring programmed by maternal protein restriction in rats.2018

    • Author(s)
      Kataoka S, Norikura T, Sato S
    • Journal Title

      Journal of Nutritional Biochemistry

      Volume: 56 Pages: 99-108

    • DOI

      10.1016/j.jnutbio.2018.01.012

    • Related Report
      2017 Research-status Report
    • Peer Reviewed
  • [Presentation] 高脂肪食摂取ラットの骨格筋中のオートファジーに及ぼすジャワショウガ抽出物並びに運動負荷の影響.2019

    • Author(s)
      佐藤 伸、乗鞍敏夫、片岡沙織、向井友花.
    • Organizer
      第73回日本栄養・食糧学会大会
    • Related Report
      2019 Annual Research Report
  • [Presentation] 高脂肪食を摂取した老化促進マウス(SAMP8)の骨格筋中の炎症細胞の浸潤に及ぼすジャワショウガの影響.2019

    • Author(s)
      高橋なごみ、山口満里奈、鹿野綾乃、杉澤春奈、乗鞍敏夫、山岡 伸、向井友花、佐藤 伸.
    • Organizer
      第66回日本栄養改善学会学術総会
    • Related Report
      2019 Annual Research Report
  • [Presentation] 胎生期・乳児期に低蛋白食に曝された仔ラットの離乳後の高脂肪食摂取による腎障害に及ぼすケルセチンの影響.2019

    • Author(s)
      山口満里奈、鹿野綾乃、高橋なごみ、山岡伸、向井友花、佐藤 伸.
    • Organizer
      第66回日本栄養改善学会学術総会
    • Related Report
      2019 Annual Research Report
  • [Presentation] 胎生期乳児期に低栄養に曝された仔ラットの高脂肪食による肝臓の炎症細胞浸潤に及ぼすケルセチンの影響2019

    • Author(s)
      鹿野綾乃、山口満里奈、高橋なごみ、山岡伸、向井友花、佐藤 伸.
    • Organizer
      第66回日本栄養改善学会学術総会
    • Related Report
      2019 Annual Research Report
  • [Presentation] タカキビ抽出物が糖尿病ラットの脂質代謝と肝臓へのマクロファージ浸潤に及ぼす影響2018

    • Author(s)
      向井友花、佐藤伸
    • Organizer
      第72回日本栄養・食糧学会大会
    • Related Report
      2018 Research-status Report
  • [Presentation] 胎生期及び乳児期に低栄養に曝された仔ラットの離乳後高脂肪食負荷による腎臓の炎症細胞に及ぼす茶カテキン類の影響2018

    • Author(s)
      佐藤 伸、片岡 沙織、乗鞍 敏夫
    • Organizer
      第4回日本栄養改善学会 東北支部学術総会
    • Related Report
      2018 Research-status Report
  • [Presentation] 胎生期乳児期に低蛋白食に曝された雌性仔ラットの離乳後の骨格筋組織に及ぼす過剰果糖液摂取の影響2018

    • Author(s)
      菅野 萌、戸巻 理奈、林 和佳奈、對馬 和、向井 友花、佐藤 伸
    • Organizer
      第65回日本栄養改善学会学術総会
    • Related Report
      2018 Research-status Report
  • [Presentation] 高脂肪食摂取ラットの腎障害に及ぼすジャワショウガ抽出物並びに運動負荷併用の影響2018

    • Author(s)
      對馬 和、向井友花、片岡沙織、乗鞍敏夫、佐藤 伸
    • Organizer
      第65回日本栄養改善学会学術総会
    • Related Report
      2018 Research-status Report
  • [Presentation] 胎生期乳児期に低蛋白食に曝された仔ラットの過剰果糖負荷による肝臓の炎症細胞に及ぼすケルセチンの影響2018

    • Author(s)
      戸巻 理奈、林 和佳奈、菅野 萌、對馬 和、向井 友花、佐藤 伸
    • Organizer
      第65回日本栄養改善学会学術総会
    • Related Report
      2018 Research-status Report
  • [Presentation] ケルセチンは胎生期・乳児期に低栄養に曝された仔ラットの果糖負荷による腎障害を軽減する2018

    • Author(s)
      林和佳奈、戸巻理奈、菅野 萌、對馬 和、向井友花、佐藤 伸
    • Organizer
      第65回日本栄養改善学会学術総会
    • Related Report
      2018 Research-status Report
  • [Presentation] 授乳期に摂取する茶カテキンは胎児期・乳児期に低栄養に曝された仔ラットの離乳後高脂肪食負荷による腎臓の炎症を軽減する2018

    • Author(s)
      佐藤 伸、片岡 沙織、乗鞍 敏夫
    • Organizer
      日本栄養・食糧学会北海道支部、日本栄養・食糧学会東北支部合同支部大会
    • Related Report
      2018 Research-status Report
  • [Presentation] タカキビ抽出物が糖尿病ラットの脂質代謝に及ぼす影響2017

    • Author(s)
      向井友花、真下温子、飯島史奈、佐藤伸
    • Organizer
      日本食品科学工学会 第64 回大会
    • Related Report
      2017 Research-status Report
  • [Presentation] 胎生期及び乳児期に高脂肪食に曝された雄性仔ラットの成長後の脂肪組織に及ぼす緑茶抽出物の影響2017

    • Author(s)
      櫻井南奈、片岡沙織、向井友花、佐藤伸
    • Organizer
      第64回日本栄養改善学会学術総会
    • Related Report
      2017 Research-status Report
  • [Presentation] 高脂肪食摂取ラットの脂肪組織及び骨格筋中の炎症細胞の浸潤に及ぼすジャワショウガ並びに運動負荷の影響2017

    • Author(s)
      高橋あかね、佐藤恵、梶田光里、片岡沙織、向井友花、乗鞍敏夫、佐藤伸
    • Organizer
      第64回日本栄養改善学会学術総会
    • Related Report
      2017 Research-status Report

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Published: 2017-04-28   Modified: 2021-02-19  

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