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Elucidation of dietary habits suitable for the control of serum phosphorus levels

Research Project

Project/Area Number 17K00927
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Eating habits
Research InstitutionFukuoka Women's University (2021)
Sugiyama Jogakuen University (2017-2020)

Principal Investigator

Sakuma Masae  福岡女子大学, 国際文理学部, 准教授 (10551749)

Project Period (FY) 2017-04-01 – 2022-03-31
Project Status Completed (Fiscal Year 2021)
Budget Amount *help
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2019: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2018: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2017: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Keywordsリン / 血清リン濃度 / 食習慣 / 高脂質食 / 栄養学
Outline of Final Research Achievements

Since elevated serum phosphorus levels are strongly associated with the development of atherosclerotic diseases, the control of serum phosphorus levels must be controlled even healthy individuals. Therefore, the purpose of this study was to elucidate the dietary habits suitable for the control of serum phosphorus levels.
The effects of dietary fat on phosphorus metabolism were examined in rats, suggesting that a high fat diet, particularly high saturated fatty acid diet, increases intestinal phosphate absorption compared with control. In addition, the association between serum phosphorus concentration and food intake status was evaluated in young healthy subjects, suggesting that high frequency of confectionery and noodle intake may be associated with high serum phosphorus levels.

Academic Significance and Societal Importance of the Research Achievements

血清リン濃度の上昇は、高血糖・高血圧・脂質異常症などの生活習慣病と同様に動脈硬化を惹起する因子であるが、その危険性に対する世間の認知度は低く、適切な食事療法についても十分に解明されていない。本研究は、健康に及ぼす危険性が高いにも関わらず、あまり注目されてこなかった「食習慣による血清リン濃度の管理」に焦点を当てた研究である。本研究結果は、食習慣による血清リン濃度の管理に役立つことが考えられ、健康長寿の達成や、増加の一途を辿っている医療費の削減に貢献できると考えられる。

Report

(6 results)
  • 2021 Annual Research Report   Final Research Report ( PDF )
  • 2020 Research-status Report
  • 2019 Research-status Report
  • 2018 Research-status Report
  • 2017 Research-status Report
  • Research Products

    (27 results)

All 2021 2020 2019 2018 2017

All Journal Article (8 results) (of which Int'l Joint Research: 2 results,  Peer Reviewed: 8 results,  Open Access: 6 results,  Acknowledgement Compliant: 1 results) Presentation (18 results) (of which Int'l Joint Research: 2 results,  Invited: 1 results) Book (1 results)

  • [Journal Article] Greater consumption of noodle is associated with higher serum phosphorus levels: a cross-sectional study on healthy participants2021

    • Author(s)
      Saito Y, Sakuma M, Narishima Y, Yoshida T, Kumagai H, Arai H
    • Journal Title

      Journal of Clinical Biochemistry and Nutrition

      Volume: 68 Issue: 1 Pages: 78-85

    • DOI

      10.3164/jcbn.20-23

    • NAID

      130007965307

    • ISSN
      0912-0009, 1880-5086
    • Related Report
      2020 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] High-fat diets provoke phosphorus absorption from the small intestine in rats.2020

    • Author(s)
      Kawamoto K, Sakuma M, Tanaka S, Masuda M, Nakao-Muraoka M, Niida Y, Nakamatsu Y, Ito M, Taketani Y, Arai H.
    • Journal Title

      Nutrition

      Volume: 72 Pages: 110694-110694

    • DOI

      10.1016/j.nut.2019.110694

    • NAID

      120006939630

    • Related Report
      2019 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Relationship between age-related decreases in serum 25-hydroxyvitamin D levels and skeletal muscle mass in Japanese women2020

    • Author(s)
      Sato M, Morishita T, Katayama T, Satomura S, Okuno H, Sumida N, Sakuma M, Arai H, Katoh S, Sairyo K, Kawaura A, Takeda E.
    • Journal Title

      The Journal of Medical Investigation

      Volume: 67 Issue: 1.2 Pages: 151-157

    • DOI

      10.2152/jmi.67.151

    • NAID

      130007839831

    • ISSN
      1343-1420, 1349-6867
    • Related Report
      2019 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Habitual confectionery intake is associated with serum phosphorus levels: A cross-sectional study on healthy subjects2019

    • Author(s)
      Saito Y, Sakuma M, Narishima Y, Yoshida T, Kumagai H, Arai H
    • Journal Title

      The Journal of Medical Investigation

      Volume: 66 Pages: 134-140

    • NAID

      130007638762

    • Related Report
      2018 Research-status Report
    • Peer Reviewed
  • [Journal Article] Soymilk intake has desirable effects on phosphorus and calcium metabolism2018

    • Author(s)
      Sakuma M, Suzuki A, Kikuchi M, Arai H
    • Journal Title

      Journal of Clinical Biochemistry and Nutrition

      Volume: 62 Issue: 3 Pages: 259-263

    • DOI

      10.3164/jcbn.17-79

    • NAID

      130006730781

    • ISSN
      0912-0009, 1880-5086
    • Related Report
      2018 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Skeletal muscle mass of old Japanese women suffering from walking difficulty in nursing home2018

    • Author(s)
      Morishita T, Sato M, Kume H, Sakuma M, Arai H, Katayama T, Katoh S, Sairyo K, Takeda E.
    • Journal Title

      The Journal of Medical Investigation

      Volume: 65 Issue: 1.2 Pages: 122-130

    • DOI

      10.2152/jmi.65.122

    • NAID

      130006575577

    • ISSN
      1343-1420, 1349-6867
    • Related Report
      2017 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Availability of 24-h urine collection method on dietary phosphorus intake estimation2017

    • Author(s)
      Sakuma M, Morimoto Y, Suzuki Y, Suzuki A, Noda S, Nishino K, Ando S, Ishikawa M, Arai H.
    • Journal Title

      Journal of Clinical Biochemistry and Nutrition

      Volume: 60 Issue: 2 Pages: 125-129

    • DOI

      10.3164/jcbn.16-50

    • NAID

      130005398538

    • ISSN
      0912-0009, 1880-5086
    • Related Report
      2017 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] 若年者における24時間蓄尿法によるリン摂取量の把握およびリン摂取量に影響を及ぼす食品構成の評価2017

    • Author(s)
      佐久間理英、太田紘之、新井英一
    • Journal Title

      栄養学雑誌

      Volume: 75 Pages: 131-140

    • NAID

      130006198858

    • Related Report
      2017 Research-status Report
    • Peer Reviewed
  • [Presentation] 若年健常女性における血清リン濃度と体組成の関連性2021

    • Author(s)
      佐久間 理英
    • Organizer
      第68回日本栄養改善学会学術総会
    • Related Report
      2021 Annual Research Report
  • [Presentation] 歩行障害を呈する介護施設高齢者の筋肉量、筋力・筋 機能低下とビタミンD 欠乏2020

    • Author(s)
      武田 英二
    • Organizer
      第23回日本病態栄養学会年次学術集会
    • Related Report
      2019 Research-status Report
  • [Presentation] 茹で調理が食品のリン含有量と嗜好性に及ぼす影響2019

    • Author(s)
      佐久間 理英
    • Organizer
      第73回日本栄養・食糧学会大会
    • Related Report
      2019 Research-status Report
  • [Presentation] Effects of boiling on phosphorus content and palatability of meats2019

    • Author(s)
      Masae Sakuma
    • Organizer
      13th Asia Congress of Nutrition
    • Related Report
      2019 Research-status Report
    • Int'l Joint Research
  • [Presentation] 若年健常女性におけるリン・カルシウム代謝に及ぼす外食摂取頻度の影響2019

    • Author(s)
      竹内 万莉乃
    • Organizer
      第66回日本栄養改善学会学術総会
    • Related Report
      2019 Research-status Report
  • [Presentation] Dietary phosphorus and human health2019

    • Author(s)
      Masae Sakuma
    • Organizer
      The 7th International Conference on Food Factors
    • Related Report
      2019 Research-status Report
    • Int'l Joint Research / Invited
  • [Presentation] 血清リン濃度およびリン代謝調節因子に及ぼす習慣的な主食摂取パターンの影響2019

    • Author(s)
      齋藤 瑛介
    • Organizer
      第22回日本病態栄養学会年次学術集会
    • Related Report
      2018 Research-status Report
  • [Presentation] 茹で調理が肉および魚のリン、たんぱく質含有量に及ぼす影響2018

    • Author(s)
      佐久間 理英
    • Organizer
      第72回日本栄養・食糧学会大会
    • Related Report
      2018 Research-status Report
  • [Presentation] 腸管リン吸収に及ぼす高脂肪食摂取の影響2018

    • Author(s)
      新井 英一
    • Organizer
      第72回日本栄養・食糧学会大会
    • Related Report
      2018 Research-status Report
  • [Presentation] 透析患者の食事療法における茹で調理の有用性の評価2018

    • Author(s)
      佐久間 理英
    • Organizer
      第7回日本栄養改善学会東海支部会学術総会
    • Related Report
      2018 Research-status Report
  • [Presentation] 脂肪酸の種類がリン代謝動態に及ぼす影響2018

    • Author(s)
      秋山 萌
    • Organizer
      第6回日本腎栄養代謝研究会
    • Related Report
      2018 Research-status Report
  • [Presentation] 若年健常者において習慣的な菓子類摂取は血清リン濃度と関係する2018

    • Author(s)
      齋藤 瑛介
    • Organizer
      第6回日本腎栄養代謝研究会
    • Related Report
      2018 Research-status Report
  • [Presentation] 若年者におけるマグネシウム摂取量の評価およびカルシウム・リン代謝指標との関連性2018

    • Author(s)
      金子 麻由
    • Organizer
      第65回日本栄養改善学会総会
    • Related Report
      2018 Research-status Report
  • [Presentation] 生体内リン代謝に及ぼす性別および体格の影響2018

    • Author(s)
      竹内万莉乃
    • Organizer
      第65回日本栄養改善学会総会
    • Related Report
      2018 Research-status Report
  • [Presentation] 脂肪酸の質の異なる高脂肪食摂取が腸管リン吸収に及ぼす影響2018

    • Author(s)
      川上 由香
    • Organizer
      第40回日本臨床栄養学会総会
    • Related Report
      2018 Research-status Report
  • [Presentation] 介護施設入所高齢者の筋肉量と栄養評価2018

    • Author(s)
      武田英二
    • Organizer
      第21回日本病態栄養学会年次学術集会
    • Related Report
      2017 Research-status Report
  • [Presentation] 糖・脂肪の組成比率がリン代謝動態に及ぼす影響2017

    • Author(s)
      川本桂祐
    • Organizer
      第5回日本腎栄養代謝研究会
    • Related Report
      2017 Research-status Report
  • [Presentation] 血清リン濃度の管理における豆乳の有効性の評価2017

    • Author(s)
      佐久間理英
    • Organizer
      第64回日本栄養改善学会学術総会
    • Related Report
      2017 Research-status Report
  • [Book] リンの事典2017

    • Author(s)
      大竹久夫
    • Total Pages
      360
    • Publisher
      朝倉書店
    • ISBN
      9784254141047
    • Related Report
      2017 Research-status Report

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Published: 2017-04-28   Modified: 2023-01-30  

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