Elucidation of dietary habits suitable for the control of serum phosphorus levels

• Project/Area Number: 17K00927
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Eating habits
• Research Institution: Fukuoka Women's University (2021); Sugiyama Jogakuen University (2017-2020)
• Principal Investigator: Sakuma Masae 福岡女子大学, 国際文理学部, 准教授 (10551749)
• Project Period (FY): 2017-04-01 – 2022-03-31
• Project Status: Completed (Fiscal Year 2021)
• Budget Amount: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000); Fiscal Year 2019: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2018: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2017: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
• Keywords: リン / 血清リン濃度 / 食習慣 / 高脂質食 / 栄養学

Outline of Final Research Achievements

Since elevated serum phosphorus levels are strongly associated with the development of atherosclerotic diseases, the control of serum phosphorus levels must be controlled even healthy individuals. Therefore, the purpose of this study was to elucidate the dietary habits suitable for the control of serum phosphorus levels.
The effects of dietary fat on phosphorus metabolism were examined in rats, suggesting that a high fat diet, particularly high saturated fatty acid diet, increases intestinal phosphate absorption compared with control. In addition, the association between serum phosphorus concentration and food intake status was evaluated in young healthy subjects, suggesting that high frequency of confectionery and noodle intake may be associated with high serum phosphorus levels.

Academic Significance and Societal Importance of the Research Achievements

血清リン濃度の上昇は、高血糖・高血圧・脂質異常症などの生活習慣病と同様に動脈硬化を惹起する因子であるが、その危険性に対する世間の認知度は低く、適切な食事療法についても十分に解明されていない。本研究は、健康に及ぼす危険性が高いにも関わらず、あまり注目されてこなかった「食習慣による血清リン濃度の管理」に焦点を当てた研究である。本研究結果は、食習慣による血清リン濃度の管理に役立つことが考えられ、健康長寿の達成や、増加の一途を辿っている医療費の削減に貢献できると考えられる。

Research Products

• [Journal Article] Greater consumption of noodle is associated with higher serum phosphorus levels: a cross-sectional study on healthy participants (2021)
  • Author(s): Saito Y, Sakuma M, Narishima Y, Yoshida T, Kumagai H, Arai H
  • Journal Title: Journal of Clinical Biochemistry and Nutrition Volume: 68 Issue: 1 Pages: 78-85
  • DOI: 10.3164/jcbn.20-23
  • NAID: 130007965307
  • ISSN: 0912-0009, 1880-5086
  • Peer Reviewed / Open Access
• [Journal Article] High-fat diets provoke phosphorus absorption from the small intestine in rats. (2020)
  • Author(s): Kawamoto K, Sakuma M, Tanaka S, Masuda M, Nakao-Muraoka M, Niida Y, Nakamatsu Y, Ito M, Taketani Y, Arai H.
  • Journal Title: Nutrition Volume: 72 Pages: 110694-110694
  • DOI: 10.1016/j.nut.2019.110694
  • NAID: 120006939630
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Relationship between age-related decreases in serum 25-hydroxyvitamin D levels and skeletal muscle mass in Japanese women (2020)
  • Author(s): Sato M, Morishita T, Katayama T, Satomura S, Okuno H, Sumida N, Sakuma M, Arai H, Katoh S, Sairyo K, Kawaura A, Takeda E.
  • Journal Title: The Journal of Medical Investigation Volume: 67 Issue: 1.2 Pages: 151-157
  • DOI: 10.2152/jmi.67.151
  • NAID: 130007839831
  • ISSN: 1343-1420, 1349-6867
  • Peer Reviewed / Open Access
• [Journal Article] Habitual confectionery intake is associated with serum phosphorus levels: A cross-sectional study on healthy subjects (2019)
  • Author(s): Saito Y, Sakuma M, Narishima Y, Yoshida T, Kumagai H, Arai H
  • Journal Title: The Journal of Medical Investigation Volume: 66 Pages: 134-140
  • NAID: 130007638762
  • Peer Reviewed
• [Journal Article] Soymilk intake has desirable effects on phosphorus and calcium metabolism (2018)
  • Author(s): Sakuma M, Suzuki A, Kikuchi M, Arai H
  • Journal Title: Journal of Clinical Biochemistry and Nutrition Volume: 62 Issue: 3 Pages: 259-263
  • DOI: 10.3164/jcbn.17-79
  • NAID: 130006730781
  • ISSN: 0912-0009, 1880-5086
  • Peer Reviewed / Open Access
• [Journal Article] Skeletal muscle mass of old Japanese women suffering from walking difficulty in nursing home (2018)
  • Author(s): Morishita T, Sato M, Kume H, Sakuma M, Arai H, Katayama T, Katoh S, Sairyo K, Takeda E.
  • Journal Title: The Journal of Medical Investigation Volume: 65 Issue: 1.2 Pages: 122-130
  • DOI: 10.2152/jmi.65.122
  • NAID: 130006575577
  • ISSN: 1343-1420, 1349-6867
  • Peer Reviewed / Open Access
• [Journal Article] Availability of 24-h urine collection method on dietary phosphorus intake estimation (2017)
  • Author(s): Sakuma M, Morimoto Y, Suzuki Y, Suzuki A, Noda S, Nishino K, Ando S, Ishikawa M, Arai H.
  • Journal Title: Journal of Clinical Biochemistry and Nutrition Volume: 60 Issue: 2 Pages: 125-129
  • DOI: 10.3164/jcbn.16-50
  • NAID: 130005398538
  • ISSN: 0912-0009, 1880-5086
  • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] 若年者における24時間蓄尿法によるリン摂取量の把握およびリン摂取量に影響を及ぼす食品構成の評価 (2017)
  • Author(s): 佐久間理英、太田紘之、新井英一
  • Journal Title: 栄養学雑誌 Volume: 75 Pages: 131-140
  • NAID: 130006198858
  • Peer Reviewed
• [Presentation] 若年健常女性における血清リン濃度と体組成の関連性 (2021)
  • Author(s): 佐久間 理英
  • Organizer: 第68回日本栄養改善学会学術総会
• [Presentation] 歩行障害を呈する介護施設高齢者の筋肉量、筋力・筋 機能低下とビタミンD 欠乏 (2020)
  • Author(s): 武田 英二
  • Organizer: 第23回日本病態栄養学会年次学術集会
• [Presentation] 茹で調理が食品のリン含有量と嗜好性に及ぼす影響 (2019)
  • Author(s): 佐久間 理英
  • Organizer: 第73回日本栄養・食糧学会大会
• [Presentation] Effects of boiling on phosphorus content and palatability of meats (2019)
  • Author(s): Masae Sakuma
  • Organizer: 13th Asia Congress of Nutrition
  • Int'l Joint Research
• [Presentation] 若年健常女性におけるリン・カルシウム代謝に及ぼす外食摂取頻度の影響 (2019)
  • Author(s): 竹内 万莉乃
  • Organizer: 第66回日本栄養改善学会学術総会
• [Presentation] Dietary phosphorus and human health (2019)
  • Author(s): Masae Sakuma
  • Organizer: The 7th International Conference on Food Factors
  • Int'l Joint Research / Invited
• [Presentation] 血清リン濃度およびリン代謝調節因子に及ぼす習慣的な主食摂取パターンの影響 (2019)
  • Author(s): 齋藤 瑛介
  • Organizer: 第22回日本病態栄養学会年次学術集会
• [Presentation] 茹で調理が肉および魚のリン、たんぱく質含有量に及ぼす影響 (2018)
  • Author(s): 佐久間 理英
  • Organizer: 第72回日本栄養・食糧学会大会
• [Presentation] 腸管リン吸収に及ぼす高脂肪食摂取の影響 (2018)
  • Author(s): 新井 英一
  • Organizer: 第72回日本栄養・食糧学会大会
• [Presentation] 透析患者の食事療法における茹で調理の有用性の評価 (2018)
  • Author(s): 佐久間 理英
  • Organizer: 第7回日本栄養改善学会東海支部会学術総会
• [Presentation] 脂肪酸の種類がリン代謝動態に及ぼす影響 (2018)
  • Author(s): 秋山 萌
  • Organizer: 第6回日本腎栄養代謝研究会
• [Presentation] 若年健常者において習慣的な菓子類摂取は血清リン濃度と関係する (2018)
  • Author(s): 齋藤 瑛介
  • Organizer: 第6回日本腎栄養代謝研究会
• [Presentation] 若年者におけるマグネシウム摂取量の評価およびカルシウム・リン代謝指標との関連性 (2018)
  • Author(s): 金子 麻由
  • Organizer: 第65回日本栄養改善学会総会
• [Presentation] 生体内リン代謝に及ぼす性別および体格の影響 (2018)
  • Author(s): 竹内万莉乃
  • Organizer: 第65回日本栄養改善学会総会
• [Presentation] 脂肪酸の質の異なる高脂肪食摂取が腸管リン吸収に及ぼす影響 (2018)
  • Author(s): 川上 由香
  • Organizer: 第40回日本臨床栄養学会総会
• [Presentation] 介護施設入所高齢者の筋肉量と栄養評価 (2018)
  • Author(s): 武田英二
  • Organizer: 第21回日本病態栄養学会年次学術集会
• [Presentation] 糖・脂肪の組成比率がリン代謝動態に及ぼす影響 (2017)
  • Author(s): 川本桂祐
  • Organizer: 第5回日本腎栄養代謝研究会
• [Presentation] 血清リン濃度の管理における豆乳の有効性の評価 (2017)
  • Author(s): 佐久間理英
  • Organizer: 第64回日本栄養改善学会学術総会
• [Book] リンの事典 (2017)
  • Author(s): 大竹久夫
  • Total Pages: 360
  • Publisher: 朝倉書店
  • ISBN: 9784254141047