Evaluation of the progression of pathological changes in Alzheimer's disease using MRI
| Project/Area Number |
17K01355
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Biomedical engineering/Biomaterial science and engineering
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| Research Institution | Shiga University of Medical Science |
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Principal Investigator |
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| Project Period (FY) |
2017-04-01 – 2020-03-31
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| Project Status |
Completed (Fiscal Year 2019)
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| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2019: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2018: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2017: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
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| Keywords | タウ / アルツハイマー病 / フッ素MRI / 遺伝子改変マウス / rTg4510 / 遺伝的背景 / タウ病理 / アミロイド病理 / MRI / 認知症 |
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| Outline of Final Research Achievements |
The aim of this study is to develop a methodology using MRI to comprehensively evaluate the pathological process in Alzheimer’s disease, such as amyloid deposition, tau pathology, and neurodegeneration. We synthesized Shiga-X35, a novel probe for 19F-MRI, and succeeded in tau imaging using Shiga-X35 in a mouse model of tauopathy, rTg450. We further conducted the researches aiming to develop a mouse model that have amyloid and tau pathology and to explore unknown factors that affect the level of tau pathology in rTg4510.
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| Academic Significance and Societal Importance of the Research Achievements |
アルツハイマー病の病理進展では、最初期にアミロイドβの沈着が始まり、次いでタウ病変の形成と神経変性が誘導されることが知られている。すなわち、個々の病理をそれぞれ解析するのではなく、統合して解析することでアルツハイマー病の病理進展の本質が理解できると推察される。しかし、これまでにそれを実現できる技術は開発されていない。本研究はアルツハイマー病の病理進展の理解に役立つ研究であり、将来のアルツハイマー病克服の一助となる成果が得られた。
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Report
(4 results)
Research Products
(24 results)
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[Journal Article] Generation of transgenic cynomolgus monkeys overexpressing the gene for amyloid-β precursor protein2020
Author(s)
Seita Y, Morimura T, Watanabe N, Iwatani C, Tsuchiya H, Nakamura S, Suzuki T, Yanagisawa D, Tsukiyama T, Nakaya M, Okamura E, Muto M, Ema M, Nishimura M, Tooyama I.
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Journal Title
Journal of Alzheimer's Disease
Volume: -
Issue: 1
Pages: 45-60
DOI
NAID
Related Report
Peer Reviewed / Open Access
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[Journal Article] Modulation of Proteome Profile in AβPP/PS1 Mice Hippocampus, Medial Prefrontal Cortex, and Striatum by Palm Oil Derived Tocotrienol-Rich Fraction.2019
Author(s)
Hamezah HS, Durani LW, Yanagisawa D, Ibrahim NF, Aizat WM, Makpol S, Wan Ngah WZ, Damanhuri HA, Tooyama I
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Journal Title
Alzheimers Dis.
Volume: 72
Issue: 1
Pages: 229-246
DOI
NAID
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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