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Characterization of Thermotherapy by Magnetic Resonance Temperature Measurement and In Silico Analysis

Research Project

Project/Area Number 17K01357
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Biomedical engineering/Biomaterial science and engineering
Research InstitutionKobe University

Principal Investigator

Kumamoto Etsuko  神戸大学, 情報基盤センター, 教授 (00221383)

Co-Investigator(Kenkyū-buntansha) 黒田 輝  東海大学, 情報理工学部, 教授 (70205243)
Project Period (FY) 2017-04-01 – 2022-03-31
Project Status Completed (Fiscal Year 2021)
Budget Amount *help
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2019: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2018: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2017: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
Keywords温熱治療 / 加温特性解析 / 集束超音波治療 / RF誘電加温 / 磁気共鳴温度分布画像化法 / 加温シミュレーション / 磁気共鳴診断装置 / 磁気共鳴画像診断装置 / 電磁界解析 / 能動型体内埋め込みデバイス / MRガイド下集束超音波治療 / 熱伝導方程式 / インシリコ解析 / 温熱療法 / 脂肪加温特性
Outline of Final Research Achievements

We analyzed the electromagnetic and thermal fields of a small RF dielectric heating device using the finite element method, and analyzed its characteristics by heating simulation based on anatomical structures. In addition, we performed a three-dimensional dynamic analysis focusing on the diaphragm in the focused ultrasound therapy of the liver with displacement and deformation due to respiratory motion, and analyzed the heating characteristics by heating simulation based on the heat transfer equation. Furthermore, we proposed a magnetic resonance temperature imaging method using resonance frequency and spin-spin relaxation time for tissues containing a mixture of water and fat. These results provide a basis and method for selecting appropriate thermal treatment methods based on body tissues.

Academic Significance and Societal Importance of the Research Achievements

本研究で得られた知見を基にした温度分布画像化法の利用や計算機シミュレーションによりは,温熱治療の治療効果および安全性の向上に寄与すると考えられる.また,水と脂肪が混在する組織の温度分布画像化法について,脂肪組織の中で支配的なメチル基および水を分離し緩和時間分布を検出することで,動物性脂肪由来の9種類の成分を同時に考慮した温度分布画像化法を提案したことで,脂肪を含む組織に対する磁気共鳴温度分布の計測精度が向上し,これまで加温モニタが困難であった脂肪を含む組織に対する温熱治療法の治療効果および安全性の向上という点においても優れた成果であると考える.

Report

(6 results)
  • 2021 Annual Research Report   Final Research Report ( PDF )
  • 2020 Research-status Report
  • 2019 Research-status Report
  • 2018 Research-status Report
  • 2017 Research-status Report
  • Research Products

    (45 results)

All 2021 2020 2019 2018 2017

All Journal Article (7 results) (of which Peer Reviewed: 6 results,  Open Access: 1 results) Presentation (37 results) (of which Int'l Joint Research: 12 results,  Invited: 3 results) Book (1 results)

  • [Journal Article] Visualization of Cerebrospinal Fluid Motion in the Whole Brain Using Three-dimensional Dynamic Improved Motion-sensitized Driven-equilibrium Steady-state Free Precession2021

    • Author(s)
      Horie Tomohiko、Kajihara Nao、Saito Haruo、Shibukawa Shuhei、Obara Makoto、Ogino Tetsuo、Niwa Tetsu、Kuroda Kagayaki、Matsumae Mitsunori
    • Journal Title

      Magnetic Resonance in Medical Sciences

      Volume: 20 Issue: 1 Pages: 112-118

    • DOI

      10.2463/mrms.tn.2019-0171

    • NAID

      130007993589

    • ISSN
      1347-3182, 1880-2206
    • Related Report
      2020 Research-status Report
    • Peer Reviewed
  • [Journal Article] Optimization of the Clinical Setting Using Numerical Simulations of the Electromagnetic Field in an Obese Patient Model for Deep Regional Hyperthermia of an 8 MHz Radiofrequency Capacitively Coupled Device in the Pelvis2021

    • Author(s)
      Ohguri Takayuki、Kuroda Kagayaki、Yahara Katsuya、Nakahara Sota、Kakinouchi Sho、Itamura Hirohide、Morisaki Takahiro、Korogi Yukunori
    • Journal Title

      Cancers

      Volume: 13 Issue: 5 Pages: 979-979

    • DOI

      10.3390/cancers13050979

    • Related Report
      2020 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Recent technological advancements in thermometry2020

    • Author(s)
      Kokuryo Daisuke、Kumamoto Etsuko、Kuroda Kagayaki
    • Journal Title

      Advanced Drug Delivery Reviews

      Volume: 163-164 Pages: 19-39

    • DOI

      10.1016/j.addr.2020.11.001

    • Related Report
      2020 Research-status Report
    • Peer Reviewed
  • [Journal Article] MRIの安全性2020

    • Author(s)
      黒田 輝
    • Journal Title

      画像診断

      Volume: 40 Pages: 220-230

    • Related Report
      2019 Research-status Report
    • Peer Reviewed
  • [Journal Article] Image reconstruction method with compressed sensing for high-speed MR temperature measurement of abdominal organs2020

    • Author(s)
      Yusuke Nakagawa , Daisuke Kokuryo , Toshiya Kaihara , Nobutada Fujii , Etsuko Kumamoto
    • Journal Title

      Proc. of 41st Annual International Conference of the IEEE Engineering in Medicine & Biology Society (EMBC)

      Volume: supl. Pages: 2731-2735

    • NAID

      40021912096

    • Related Report
      2019 Research-status Report
    • Peer Reviewed
  • [Journal Article] 研究開発の立場から見たISMRM2018のトピック2018

    • Author(s)
      黒田輝
    • Journal Title

      Innervision

      Volume: 33 Pages: 76-77

    • Related Report
      2018 Research-status Report
  • [Journal Article] MR techniques for guiding high-intensity focused ultrasound (HIFU) treatments.2018

    • Author(s)
      Kuroda K.
    • Journal Title

      J Magn Reson Imag

      Volume: 47 Issue: 2 Pages: 316-331

    • DOI

      10.1002/jmri.25770

    • Related Report
      2017 Research-status Report
    • Peer Reviewed
  • [Presentation] 前臨床MR画像における予後予測実現に向けた腫瘍の特徴量解析2021

    • Author(s)
      田中喜大, 國領大介, 貝原俊也, 藤井信忠, 熊本悦子
    • Organizer
      第65回システム制御情報学会研究発表講演会
    • Related Report
      2021 Annual Research Report
  • [Presentation] 集束超音波治療における信号収集領域を限局したMR信号を用いた照射位置追従精度の検討2021

    • Author(s)
      國領大介, 仲川侑介, 貝原俊也, 藤井信忠, 熊本悦子
    • Organizer
      第49回日本磁気共鳴医学会大会
    • Related Report
      2021 Annual Research Report
  • [Presentation] 磁気共鳴シミュレーションを用いたMR画像への定量性賦与法の提案2021

    • Author(s)
      作田隼樹, 國領大介, 貝原俊也, 藤井信忠, 熊本悦子
    • Organizer
      第64回自動制御連合講演会
    • Related Report
      2021 Annual Research Report
  • [Presentation] 能動型体内植込みデバイスの遺残リード線のRF発熱における絶縁皮膜の影響2020

    • Author(s)
      Kagayaki Kuroda, Satoshi Yatsushiro, Anju Satoh, Kanta Mukai, Daiki Endoh
    • Organizer
      第48回日本磁気共鳴医学会大会
    • Related Report
      2020 Research-status Report
  • [Presentation] Analysis of Physiological Brain Shift and Optic Chiasm in the Closed Cranium due to Postural Position2020

    • Author(s)
      Etsuko Kumamoto, Shigeto Hayashi, Ari Shinojima, Koshi Yokota, Eiji Kohmura
    • Organizer
      ISMRM 28th Scientific Meeting
    • Related Report
      2020 Research-status Report
    • Int'l Joint Research
  • [Presentation] MR Thermometry of Fat-water mixed tissues based on Methylene and Methyl T2 in conjunction with Water Proton Resonance Frequency2019

    • Author(s)
      Kuroda K, Qinyu L, Werawat C, Imai Y
    • Organizer
      1st Annu Meeting Asian Soc Magn Reson Med
    • Related Report
      2019 Research-status Report
    • Int'l Joint Research
  • [Presentation] MR Thermometry of Fat based on Synthesized Temperature Property of Methylene and Methyl Signals2019

    • Author(s)
      Kuroda K, Kurihara K, Nakata Y, Imai Y
    • Organizer
      36th Annual Meeting of Society for Thermal Mecine
    • Related Report
      2019 Research-status Report
    • Int'l Joint Research
  • [Presentation] Magnetic Resonance Imaging of Heat and Mass Transfer2019

    • Author(s)
      Kuroda K
    • Organizer
      The 12th Biomedical Engineering International Congress
    • Related Report
      2019 Research-status Report
    • Int'l Joint Research
  • [Presentation] Heat and Mass Transfer Imaging2019

    • Author(s)
      Kuroda K
    • Organizer
      1st Annu Meeting Asian Soc Magn Reson Med
    • Related Report
      2019 Research-status Report
    • Int'l Joint Research
  • [Presentation] Temperature Measurement2019

    • Author(s)
      Kuroda K
    • Organizer
      The 27th Annu Meeting Int Soc Magn Reson Med
    • Related Report
      2019 Research-status Report
    • Int'l Joint Research
  • [Presentation] Latest Trend of MR Safety with a Focus on Implantable Medical Device2019

    • Author(s)
      Kuroda K
    • Organizer
      第47回日本磁気共鳴医学会大会
    • Related Report
      2019 Research-status Report
  • [Presentation] デバイス患者のMRI撮像~現状と今後を考える~安全性評価の立場から2019

    • Author(s)
      黒田輝
    • Organizer
      日本不整脈心電学会第12回植込みデバイス関連冬季大会
    • Related Report
      2019 Research-status Report
  • [Presentation] 温熱療法の数値シミュレーションの QA のためのベンチマークテスト2019

    • Author(s)
      黒田輝, 斎藤一幸, 上村佳嗣, 進藤康弘, 伊藤公一
    • Organizer
      日本ハイパーサーミア学会 第36回大会
    • Related Report
      2019 Research-status Report
  • [Presentation] 脂肪混在組織のための共鳴周波数とスピン・スピン緩和時間を用いた MR温度分布画像化法2019

    • Author(s)
      黒田輝, 劉沁雨, 平信勇太, 渡辺拓也, 丹羽 徹, 今井 裕
    • Organizer
      日本ハイパーサーミア学会 第36回大会
    • Related Report
      2019 Research-status Report
  • [Presentation] 腹腔臓器を対象とした高速MR温度計測のための圧縮センシングを用いた画像再構成手法の検討2019

    • Author(s)
      仲川 侑介, 國領 大介, 貝原 俊也, 藤井 信忠, 熊本 悦子
    • Organizer
      第63回システム制御情報学会研究発表講演会
    • Related Report
      2019 Research-status Report
  • [Presentation] A Three-dimensional Template Matching Technique in Target Tracking Technique of MRgHIFU for liver2018

    • Author(s)
      Morita Tomoki, Kumamoto Etsuko, Kokuryo Daisuke, Kuroda Kagayaki
    • Organizer
      International Society for Magnetic Resonance in Medicine 26th Annual Meeting and Exibition
    • Related Report
      2018 Research-status Report
    • Int'l Joint Research
  • [Presentation] 高速MR温度計測のための圧縮センシングを用いた画像再構成手法の検討2018

    • Author(s)
      仲川侑介,國領大介,貝原俊也,藤井信忠,熊本悦子
    • Organizer
      第61回自動制御連合講演会
    • Related Report
      2018 Research-status Report
  • [Presentation] Imaging Conditions and Image Quality for Patients with MR-conditional Cardiac Devices: Normal Volunteer Study2018

    • Author(s)
      Kuroda K, Sunohara S, Yatsushiro S, Saito T, Shimizu S, Kajiwara N, et al
    • Organizer
      International Society for Magnetic Resonance in Medicine 26th Annual Meeting and Exibition
    • Related Report
      2018 Research-status Report
    • Int'l Joint Research
  • [Presentation] Feasibility of MR-guided RF capacitive hyperthermia operating at 8MHz2018

    • Author(s)
      Okuda Y, Sagae M, Sekiguchi T, Nomura T, Tsujiguchi M, Kuroda K
    • Organizer
      7th Asian Con Hyper Onc (ACHO)
    • Related Report
      2018 Research-status Report
    • Int'l Joint Research
  • [Presentation] Numerical simulation of properties of RF capacitive hyperthermia analyzed based on patients’ X-ray CT images2018

    • Author(s)
      Sagae M, Okuda Y, Oguri T, Sekiguchi T, Nomura T, Tsujiguchi M, et al
    • Organizer
      7th Asian Con Hyper Onc (ACHO)
    • Related Report
      2018 Research-status Report
    • Int'l Joint Research
  • [Presentation] 患者のX線CT画像から構築した数値人体モデルに基づくRF誘電加温特性の解析2018

    • Author(s)
      寒河江真生, 大栗隆行, 関口哲也, 野村哲司, 黒田輝
    • Organizer
      第22回関東・全身ハイパーサーミア研究会合同学術研究会
    • Related Report
      2018 Research-status Report 2017 Research-status Report
  • [Presentation] MRガイド下RF誘電加温のための電磁干渉シミュレーション2018

    • Author(s)
      奥田祐希, 寒河江真生, 関口哲也, 野村哲司, 黒田輝
    • Organizer
      第22回関東・全身ハイパーサーミア研究会合同学術研究会
    • Related Report
      2018 Research-status Report 2017 Research-status Report
  • [Presentation] 患者のX線CT画像から構築した数値人体モデルに基づくRF誘電加温特性の解析2018

    • Author(s)
      寒河江真生, 大栗隆行, 関口哲也, 野村哲司, 黒田輝
    • Organizer
      日本ハイパーサーミア学会第35回大会
    • Related Report
      2018 Research-status Report
  • [Presentation] Comparison of Imaging Conditions for Patients with MR-conditional Cardiac Devices: Normal Volunteer Study.2018

    • Author(s)
      Kuroda K, Sunohara S, Yatsushiro S, Saito T, Shimizu S, Kajiwara N, Horie T, Kazama T, Niwa T, Imai Y.
    • Organizer
      ISMRM Workshop on Ensuring RF Safety in MRI: Current Practices & Future Directions
    • Related Report
      2017 Research-status Report
    • Int'l Joint Research
  • [Presentation] 体内植込み型医療機器の発熱特性の解析2018

    • Author(s)
      小松巧実, 奥田祐希, 石黒誠也, 竹澤慎太郎, 黒田輝
    • Organizer
      第10回医用生体電磁気学シンポジウム
    • Related Report
      2017 Research-status Report
  • [Presentation] 肝MRgFUSにおける3次元焦点トラッキング2017

    • Author(s)
      熊本悦子,國領大介,黒田輝
    • Organizer
      第34回日本ハイパーサーミア学会第32回大会
    • Related Report
      2017 Research-status Report
    • Invited
  • [Presentation] スピン格子緩和時間による膝関節軟骨の非侵襲絶対温度分布画像化における定量性の検討2017

    • Author(s)
      木村智也, 瀧澤大佑, 高橋謙治, 黒田輝
    • Organizer
      第34回日本ハイパーサーミア学会第30回大会
    • Related Report
      2017 Research-status Report
  • [Presentation] 民間治療器による人体加温時の電磁界及び温熱界の数値解析2017

    • Author(s)
      小澤恭之, 黒田輝, 寒河江真生
    • Organizer
      第34回日本ハイパーサーミア学会第31回大会
    • Related Report
      2017 Research-status Report
  • [Presentation] RF誘電加温装置と磁気共鳴画像化装置の組み合わせに関する基礎検討2017

    • Author(s)
      寒河江真生, 黒田輝, 関口哲也, 野村哲司
    • Organizer
      第34回日本ハイパーサーミア学会第32回大会
    • Related Report
      2017 Research-status Report
  • [Presentation] 磁気共鳴画像化法による乳がんの温度分布画像法の撮像シーケンス最適化2017

    • Author(s)
      大脇陽介, 栗原賢一朗, 黒田輝, 裕 今
    • Organizer
      第34回日本ハイパーサーミア学会第33回大会
    • Related Report
      2017 Research-status Report
  • [Presentation] MRによる温度計測法の基礎と応用2017

    • Author(s)
      黒田輝
    • Organizer
      第45回日本磁気共鳴医学会大会
    • Related Report
      2017 Research-status Report
    • Invited
  • [Presentation] MRIガイド下医療を支える技術の原理2017

    • Author(s)
      黒田輝
    • Organizer
      第45回日本磁気共鳴医学会大会
    • Related Report
      2017 Research-status Report
    • Invited
  • [Presentation] 肝MRガイド下集束超音波治療における三次元照射位置追尾のためのテンプレートマッチング法の検討2017

    • Author(s)
      森田友基,熊本悦子,國領大介,黒田輝
    • Organizer
      第45回日本磁気共鳴医学会大会
    • Related Report
      2017 Research-status Report
  • [Presentation] 温熱による膝関節軟骨の疼痛緩和のためのT1による絶対温度分布画像化における定量性改善2017

    • Author(s)
      Owaki Y, Kurihara K, Kuroda K, Imai Y.
    • Organizer
      第45回日本磁気共鳴医学会大会
    • Related Report
      2017 Research-status Report
  • [Presentation] 人工股関節使用患者のMRI検査時の発熱に関する基礎的検討2017

    • Author(s)
      Okuda Y, Kuroda K
    • Organizer
      第45回日本磁気共鳴医学会大会
    • Related Report
      2017 Research-status Report
  • [Presentation] 温熱による膝関節軟骨の疼痛緩和のためのT1による絶対温度分布画像化における定量性改善2017

    • Author(s)
      Kimura T, Takizawa D, Takahashi K, Kuroda K.
    • Organizer
      第45回日本磁気共鳴医学会大会
    • Related Report
      2017 Research-status Report
  • [Presentation] A Three-dimensional Target Tracking Technique for MRgHIFU using an Image Matching Method with Liver Deformation Volumes Obtained via Time-Resolved Volume Acquisitions2017

    • Author(s)
      Kumamoto E. Kokuryo D. Kuroda K.
    • Organizer
      International Society for Magnetic Resonance in Medicine 25th Annual Meeting and Exibition
    • Related Report
      2017 Research-status Report
    • Int'l Joint Research
  • [Book] 笠井俊文・土井司編, MR撮像技術学2017

    • Author(s)
      黒田 輝
    • Total Pages
      422
    • Publisher
      日本放射線技術学会
    • Related Report
      2017 Research-status Report

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Published: 2017-04-28   Modified: 2023-01-30  

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