A model study for personalized cancer medicine by the novel chemoradiotherapy guided on the state-of-the-art spin resonance imaging
| Project/Area Number |
17K01363
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Biomedical engineering/Biomaterial science and engineering
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| Research Institution | National Institutes for Quantum and Radiological Science and Technology |
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Principal Investigator |
Takakusagi Yoichi 国立研究開発法人量子科学技術研究開発機構, 量子生命科学領域, 主任研究員(任常) (60439916)
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| Project Period (FY) |
2017-04-01 – 2021-03-31
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| Project Status |
Completed (Fiscal Year 2020)
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| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2019: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2018: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2017: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Keywords | 電子スピン共鳴 / 酸素 / 低酸素標的薬 / 動的核偏極 / ピルビン酸 / イメージング / 放射線治療 / 個別化医療 / 放射線増感剤 / 超偏極 |
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| Outline of Final Research Achievements |
In this study, a model experiment was conducted to improve the treatment outcome of cancer by using the in vivo imaging technique for the application of new chemo-radiotherapy. Prior to the treatment, physiological characteristics of tumors, such as hypoxia formation or enhanced aerobic glycolysis, which are associated with treatment resistance, were non-invasively visualized using spin resonance imaging techniques. Based on the imaging data with partial oxygen pressure (pO2) or metabolic properties, appropriate therapeutic options (type of radiosensitizer, radiation dose, and their treatment schedule) were determined to maximize the therapeutic effect. As support, imaging during the treatment as well as biopsy tests was conducted in parallel to determine the optimal treatment protocol.
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| Academic Significance and Societal Importance of the Research Achievements |
本課題の in vivo 画像技術は、癌の悪性化や治療耐性に関わる低酸素領域の形成や糖代謝の亢進を、生体を傷つけることなく超高感度かつダイナミックに調べることが可能な最先端の技術である。作用メカニズムの異なる臨床開発中の新しい放射線増感剤を組み合わせた個別化医療のモデル実験によりそれらの応用方法や有用性を具体的に示し、当該分野の先駆的な研究成果として後続の研究を牽引する。また、本成果を基盤とした臨床開発の進展により、その精度を格段に向上させた新たながん診断治療技術として、がんの治療成績の向上へと貢献する可能性が期待される。
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Report
(5 results)
Research Products
(50 results)
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[Journal Article] A Multimodal Molecular Imaging Study Evaluates Pharmacological Alteration of the Tumor Microenvironment to Improve Radiation Response2018
Author(s)
Takakusagi, Y. Naz, S. Takakusagi, K. Ishima, M. Murata, H. Ohta, K. Miura, M. Sugawara, F. Sakaguchi, K. Kishimoto, S. Munasinghe, J. P. Mitchell, J. B. Krishna, M. C.
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Journal Title
Cancer Res
Volume: 78
Issue: 24
Pages: 6828-6837
DOI
Related Report
Peer Reviewed / Int'l Joint Research
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[Journal Article] Metabolic and Physiologic Imaging Biomarkers of the Tumor Microenvironment Predict Treatment Outcome with Radiation or a Hypoxia-Activated Prodrug in Mice2018
Author(s)
Matsumoto, S. Kishimoto, S. Saito, K. Takakusagi, Y. Munasinghe, J. P. Devasahayam, N. Hart, C. P. Gillies, R. J. Mitchell, J. B. Krishna, M. C.
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Journal Title
Cancer Res
Volume: 78
Issue: 14
Pages: 3783-3792
DOI
NAID
Related Report
Peer Reviewed / Int'l Joint Research
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[Journal Article] Hyperpolarized [1-13C]-pyruvate magnetic resonance spectroscopic imaging of prostate cancer in vivo predicts efficacy of targeting the Warburg effect2018
Author(s)
Scroggins B, Matsuo M, White A, Saito K, Munasinghe JP, Sourbier C, Yamamoto K, Diaz V, Ichikawa K, Mitchell JB, Cherukuri MK, Citrin DE
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Journal Title
Clinical Cancer Research
Volume: 印刷中
Issue: 13
Pages: 3137-3148
DOI
Related Report
Peer Reviewed / Int'l Joint Research
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[Presentation] Novel Real-time Hyperpolarized 13C Metabolic Tracer Probes gamma-Glutamyl Transferase Activities in vivo Human Tumor Xenografts2020
Author(s)
Kazutoshi Yamamoto , Tomohiro Seki , Nobu Oshima , Marino Itoda , Yohei Kondo , Yutaro Saito , Yoichi Takakusagi , Shun Kishimoto , Jeffery Brender , Ronja Malinowski , Jan Henrik Ardenkjaer-Larsen , Hiroshi Nonaka , Murali Krishna , Shinsuke Sando
Organizer
61st ENC
Related Report
Int'l Joint Research
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[Presentation] Novel Real-time Hyperpolarized 13C Metabolic Tracer Probes γ-Glutamyl Transferase Activities in vivo Tumor Xenografts2020
Author(s)
Tomohiro Seki , Kazutoshi Yamamoto , Nobu Oshima , Marino Itoda , Yohei Kondo , Yutaro Saito , Yoichi Takakusagi , Shun Kishimoto , Jeffery Brender , Ronja Malinowski , Jan Henrik Ardenkjaer-Larsen , Hiroshi Nonaka , Murali C Krishna , Shinsuke Sando
Organizer
ISMRM
Related Report
Int'l Joint Research
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[Presentation] 生体内ペプチダーゼ活性検出のための実用的量子超偏極 MRI 分子プローブ開発2020
Author(s)
齋藤雄太朗 , 谷田部浩行 , 田村伊織 , 近藤洋平 , 石田諒 , 関智宏 , 江口晃弘 , 高草木洋一 , 山本和俊 , Murali C. Krishna , 山東信介
Organizer
量子生命科学会第 2 回大会
Related Report
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[Presentation] 生体内アミノペプチダーゼN活性を検出する超偏極分子プローブの開発2020
Author(s)
齋藤雄太朗 , 谷田部浩行 , 田村伊織 , 近藤洋平 , 石田諒 , 関智宏 , 江口晃弘 , 高草木洋一 , 山本和俊 , Murali C Krishna , 山東信介
Organizer
第 14 回バイオ関連化学シンポジウム 2020
Related Report
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[Presentation] A multimodal molecular imaging study of tumor microenvironment to reveal the mechanism of tumor radiosensitization elicited by a natural sulfoglycolipid2019
Author(s)
Yoichi Takakusagi, Shingo Matsumoto, Masayuki Matsuo, Kaori Takakusagi, Keita Saito, Shun Kishimoto, Masahiko Miura, Toshiyasu Miyazaki, Fumio Sugawara, Kengo Sakaguchi, James B Mitchell, Murali C Krishna
Organizer
第 14 回日本分子イメージング学会総会・学術集会、日本分子イメージング学会
Related Report
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