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Suppression of the high risk arrythmia: investigation for practical suppression methods using both numerical and animal models

Research Project

Project/Area Number 17K01364
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Biomedical engineering/Biomaterial science and engineering
Research InstitutionTokyo Metropolitan University

Principal Investigator

Yazawa Toru  首都大学東京, 理学研究科, 客員研究員 (30106603)

Project Period (FY) 2017-04-01 – 2020-03-31
Project Status Completed (Fiscal Year 2019)
Budget Amount *help
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2019: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2018: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2017: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Keywords不整脈 / alternans / 無脊椎動物モデル / 数理モデル / 心臓 / 死の予兆 / Alternans / 無脊椎動物 / 生理学
Outline of Final Research Achievements

Alternans heartbeat is called as harbinger of death rhythm, which was first documented by German physician Dr. Traube in 1872. Over one hundred years have passed since then. However the mechanisms of its generation are still a mystery. I investigated when animal hearts generate alternans. I found that alternans is observable when animals are at a terminal condition. Numerical simulation study with Dr. Kitajima at Kagawa U. revealed that the equation can generate alternans at a certain condition. For preventing generation of alternans, sodium channel characteristics, probably controlled by genetic regulation, potassium concentration in blood, and calcium availability for myocardial cells are key factors.

Academic Significance and Societal Importance of the Research Achievements

突然死は、院外において発生した場合に特に問題である。少なくとも心臓に既往症があり生還した者には深刻で再発は防止したい。防止に重要なポイントは、突然発生してもおかしくない「状況」の早めの察知である。この状況の本質が本研究で明らかになった。心筋細胞において、何らかの事情でNaイオンチャンネルをNaイオンが通過しにくいこと、何らかの事情でKイオンの血中濃度が上昇してしまったこと、そしてCaイオンの可用性(利用[使用]できる度合い)が減少したこと、少なくとも以上の3点である。既往症がない場合でも同じ理由で発生するので、常時監視技術の進歩により心臓突然死の災難は減じられるだろう。

Report

(4 results)
  • 2019 Annual Research Report   Final Research Report ( PDF )
  • 2018 Research-status Report
  • 2017 Research-status Report
  • Research Products

    (25 results)

All 2020 2019 2018 2017

All Journal Article (12 results) (of which Int'l Joint Research: 6 results,  Peer Reviewed: 12 results,  Open Access: 9 results) Presentation (10 results) (of which Int'l Joint Research: 8 results,  Invited: 2 results) Book (1 results) Patent(Industrial Property Rights) (2 results) (of which Overseas: 1 results)

  • [Journal Article] Pulsus alternans in a crustacean cardiac model2020

    • Author(s)
      Kitajima Hiroyuki、Fujimoto Ken’ichi、Yazawa Toru
    • Journal Title

      Physica D: Nonlinear Phenomena

      Volume: 402 Pages: 132253-132253

    • DOI

      10.1016/j.physd.2019.132253

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] mDFA Detects Abnormality: From Heartbeat to Material Vibration2019

    • Author(s)
      Yazawa, T., Omata, S.
    • Journal Title

      Noise and Vibration Control - From Theory to Practice

      Volume: 1 Pages: 1-23

    • DOI

      10.5772/intechopen.85798

    • ISBN
      9781789847703, 9781789847710
    • Related Report
      2019 Annual Research Report 2018 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Quantifying the Mind: Worry, Tension, and Anxiety2019

    • Author(s)
      Yazawa, Toru
    • Journal Title

      Transactions on Engineering Technologies World Congress on Engineering and Computer Science 2017. Editors: Ao, Sio-Iong, Kim, Haeng Kon, Amouzegar, Mahyar A.

      Volume: 1 Pages: 353-362

    • DOI

      10.1007/978-981-13-2191-7_25

    • ISBN
      9789811321900, 9789811321917
    • Related Report
      2019 Annual Research Report 2018 Research-status Report
    • Peer Reviewed
  • [Journal Article] Health wellness monitoring using the scaling exponent: a heartbeat interval time series analysis2018

    • Author(s)
      Yazawa T
    • Journal Title

      Proceedings of The 9th International Multi-Conference on Complexity, Informatics and Cybernetics (IMCIC 2018)

      Volume: 1 Pages: 128-133

    • Related Report
      2018 Research-status Report
    • Peer Reviewed
  • [Journal Article] Health wellness monitoring using the scaling exponent: a heartbeat interval time series analysis2018

    • Author(s)
      Yazawa T, Kitajima H
    • Journal Title

      Journal of Systematics, Cybernetics and Informatics

      Volume: 16 Pages: 74-80

    • Related Report
      2018 Research-status Report
    • Peer Reviewed
  • [Journal Article] Anxiety, Worry and Fear: Quantifying the Mind Using EKG2018

    • Author(s)
      T Yazawa
    • Journal Title

      In: Time Series Analysis and Applications, Chapter 2, Edited by Nawaz Mohamudally, Published by InTech Janeza Trdine 9, 51000 Rijeka, Croatia.

      Volume: I Pages: 7-22

    • Related Report
      2017 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Health wellness monitoring using the scaling exponent: a heartbeat interval time series analysis.2018

    • Author(s)
      T Yazawa
    • Journal Title

      Proceedings of The 9th International Multi-Conference on Complexity, Informatics and Cybernetics (IMCIC 2018)

      Volume: I Pages: 128-133

    • Related Report
      2017 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Quantifying the Mind: Worry, Tension, and Anxiety.2018

    • Author(s)
      T Yazawa  in press
    • Journal Title

      In: Transactions on Engineering Technologies: WCECS 2017, Eds, Sio-Iong Ao, Haeng Kon Kim, Mahyar A. Amouzegar, Springer. Chapter ##,

      Volume: -

    • Related Report
      2017 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Invisible Emotion, Anxiety and Fear: Quantifying the Mind Using EKG with mDFA.2017

    • Author(s)
      T Yazawa
    • Journal Title

      Proceedings of The 8th International Multi-Conference on Complexity, Informatics and Cybernetics (IMCIC 2017)

      Volume: I Pages: 201-205

    • Related Report
      2017 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Invisible Emotion, Anxiety and Fear: Quantifying the Mind Using EKG with mDFA2017

    • Author(s)
      T Yazawa
    • Journal Title

      Journal of Systemics, Cybernetics and Informatics (JSCI)

      Volume: I Pages: 84-88

    • Related Report
      2017 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Anxiety, Worry, and Fear: Quantifying the mind using EKG-mDFA Method.2017

    • Author(s)
      T Yazawa
    • Journal Title

      Proceedings of the World Congress on Engineering and Computer Science 2017

      Volume: II Pages: 519-524

    • Related Report
      2017 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Bifurcation in a crustacean cardiac model.2017

    • Author(s)
      Akatsuki ABE, Hiroyuki KITAJIMA, and Toru YAZAWA
    • Journal Title

      電子情報通信学会 IEICE Technical Report NLP2017-96(2018-01)

      Volume: I Pages: 55-57

    • Related Report
      2017 Research-status Report
    • Peer Reviewed / Open Access
  • [Presentation] A Life-Threatening Pulse, Alternans, Lowers the Scaling2019

    • Author(s)
      Toru Yazawa, Hiroyuki Kitajima
    • Organizer
      29 th Annual Conference of the Society for Chaos Theory in Psychology and Life Sciences
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Scaling Exponents Computed by EKG-mDFA Method Serve as a Useful Bioindex: A Heartbeat Analysis for Speedy Health Detection2018

    • Author(s)
      Yazawa T
    • Organizer
      28th Society for Chaos Theory in Psychology & Life Sciences
    • Related Report
      2018 Research-status Report
    • Int'l Joint Research
  • [Presentation] Heartbeat analysis for speedy disease/health detection: The scaling exponents computed by EKG-mDFA serve as a useful bioindex2018

    • Author(s)
      Yazawa T
    • Organizer
      Society for Neuroscience 2018
    • Related Report
      2018 Research-status Report
    • Int'l Joint Research
  • [Presentation] Health Wellness Monitoring Using the Scaling Exponent: A Heartbeat Interval Time Series Analysis.2018

    • Author(s)
      T Yazawa
    • Organizer
      The 9th International Multi-Conference on Complexity, Informatics and Cybernetics: IMCIC 2018, シンポジウムHealth Care and Bio-Medicine I
    • Related Report
      2017 Research-status Report
    • Int'l Joint Research
  • [Presentation] Invisible Emotion, Anxiety and Fear: Quantifying the Mind Using EKG with mDFA2017

    • Author(s)
      T Yazawa
    • Organizer
      国際会議IMCIC 2017
    • Related Report
      2017 Research-status Report
    • Int'l Joint Research
  • [Presentation] Anxiety and Fear: Quantifying the Mind Using EKG with mDFA2017

    • Author(s)
      T Yazawa
    • Organizer
      国際自律神経学会ISAN2017 Symposium 17 Central circuitries controlling autonomic physiological response to stressful events.
    • Related Report
      2017 Research-status Report
    • Int'l Joint Research
  • [Presentation] Anxiety, Worry, and Fear: Quantifying the Mind Using EKG-mDFA Method2017

    • Author(s)
      T Yazawa
    • Organizer
      Int. Conf. on Soft Computing Applications, WCECS 2017
    • Related Report
      2017 Research-status Report
    • Int'l Joint Research
  • [Presentation] A method for the measurement of autonomic control: Quantitative analysis of the properties of cardiovascular dynamics using the scaling exponent computed by mDFA.2017

    • Author(s)
      T Yazawa
    • Organizer
      SFN 北米神経科学会
    • Related Report
      2017 Research-status Report
    • Int'l Joint Research
  • [Presentation] mDFA2017

    • Author(s)
      T Yazawa
    • Organizer
      JISS(国立スポーツ科学センター)
    • Related Report
      2017 Research-status Report
    • Invited
  • [Presentation] 「カニからヒトまでの心臓の話」ー心臓はこころの窓ー2017

    • Author(s)
      T Yazawa
    • Organizer
      国立大学法人北海道教育大 附属旭川中学校
    • Related Report
      2017 Research-status Report
    • Invited
  • [Book] Transactions on Engineering Technologies World Congress on Engineering and Computer Science 2017, Editors: Ao, Sio-Iong, Kim, Haeng Kon, Amouzegar, Mahyar A.2019

    • Author(s)
      Yazawa, Toru
    • Total Pages
      397
    • Publisher
      Springer Nature Singapore Pte Ltd.
    • ISBN
      9789811321900
    • Related Report
      2019 Annual Research Report
  • [Patent(Industrial Property Rights)] 信号解析システム、方法およびプログラム2019

    • Inventor(s)
      Yazawa T
    • Industrial Property Rights Holder
      矢澤徹 霜田幸雄 株)シンフォディアフィル
    • Industrial Property Rights Type
      特許
    • Filing Date
      2019
    • Acquisition Date
      2019
    • Related Report
      2018 Research-status Report
    • Overseas
  • [Patent(Industrial Property Rights)] 信号解析システム、方法およびプログラム2018

    • Inventor(s)
      矢澤徹・霜田幸雄
    • Industrial Property Rights Holder
      矢澤徹・霜田幸雄
    • Industrial Property Rights Type
      特許
    • Industrial Property Number
      2018-028404
    • Filing Date
      2018
    • Related Report
      2017 Research-status Report

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Published: 2017-04-28   Modified: 2021-02-19  

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