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Development of a non-invasive blood glucose sensor without calibration

Research Project

Project/Area Number 17K01384
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Biomedical engineering/Biomaterial science and engineering
Research InstitutionNational Institutes for Quantum and Radiological Science and Technology

Principal Investigator

KOICHI YAMAKAWA  国立研究開発法人量子科学技術研究開発機構, 関西光科学研究所 光量子科学研究部, グループリーダー(定常) (40360408)

Project Period (FY) 2017-04-01 – 2020-03-31
Project Status Completed (Fiscal Year 2019)
Budget Amount *help
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2019: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2018: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
Fiscal Year 2017: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Keywords非侵襲 / 血糖 / レーザー / 中赤外線 / 非侵襲計測 / 糖尿病 / 赤外レーザー / 医療・福祉 / 応用光学・量子光工学
Outline of Final Research Achievements

We have developed a non-invasive glucose sensor without calibration by using two color mid-infrared (MIR) lasers. The glucose concentrations in blood were taken for three healthy volunteers during 3 months using a standard oral glucose tolerance test (OGTT). Numerical values for the subjects' glucose concentration levels were obtained using commercial self-monitoring of blood glucose prior to in vivo optical experiments. As a result, the precision of our two color MIR glucose sensor was improved compared with the monochromatic MIR sensor even if individual differences exist.

Academic Significance and Societal Importance of the Research Achievements

世界で4億人を超える糖尿病患者は、1日4-5回、指などを針で穿刺する採血型自己血糖値センサーを用いて血糖値を測定しなければならず、痛みや精神的ストレス、さらに感染症の危険を伴うなどの多くの問題をかかえている。針を刺さず(非侵襲)に連続的に血糖値測定ができれば、患者の負担を大幅に低減でき、また穿刺針やセンサーチップなどの医療廃棄物ゼロに出来るため、感染症の危険が無くなる。そして、非侵襲性の長所を最大限生かし、自宅や会社、ドラッグストアなどへの設置による、健常者を含めた気軽な健康・血糖値管理に活用することで、糖尿病人口の増加抑制はもちろん、年々増加する医療費の削減とともに、健康寿命の延伸を目指す。

Report

(3 results)
  • 2019 Final Research Report ( PDF )
  • 2018 Research-status Report
  • 2017 Research-status Report

URL: 

Published: 2017-04-28   Modified: 2025-03-27  

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