Utilization of new materials to make practical use of electrophoresis Coulter method (ECM) as medical inspection equipment
Project/Area Number |
17K01394
|
Research Category |
Grant-in-Aid for Scientific Research (C)
|
Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Biomedical engineering/Biomaterial science and engineering
|
Research Institution | Toyo University |
Principal Investigator |
|
Co-Investigator(Kenkyū-buntansha) |
中島 義賢 大阪大学, ナノサイエンスデザイン教育研究センター, 特任准教授(常勤) (40408993)
水木 徹 東洋大学, バイオ・ナノエレクトロニクス研究センター, 研究助手 (80408997)
|
Project Period (FY) |
2017-04-01 – 2020-03-31
|
Project Status |
Completed (Fiscal Year 2019)
|
Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2019: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2018: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2017: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
|
Keywords | マイクロチャネル / 電気泳動 / ゼータ電位 / コールター法 / ECM / POCT / 電気泳動法 / コールター / イットリウム水素化物 / グラフェン / マイクロ流路 / 電気泳動コールター法(ECM) / ヒト多発性骨髄腫・Bリンパ球様(IM-9) / アポトーシス細胞 / マイクロ・ナノデバイス / ナノ材料 / SOQ |
Outline of Final Research Achievements |
We demonstrated that the ECM can identify whether the present cell state is alive or dead for solutions of IM-9 cells, both before and after dosing using an apoptosis inducer. This approach can be applied to other biological cells and biomaterials, for cases in which their size and/or zeta-potential distributions are influenced by disease. Therefore, the ECM is promising for realization of quick point-of-care diagnostics, such as blood glucose monitoring for diabetic patients and early-stage detection of various diseases in remote healthcare. We also demonstrated that Yttrium hydride (YHx) will be helpful as semiconducting materials for FETs, which would be combined with ECM and graphene oxide(GO) are useful as passivation films of YHx. We also proposed the H-shaped microchannel for suppressing the pressure gradient flow and demonstrated the measurement of the electrophoretic velocity of cells using the proposal microchannel.
|
Academic Significance and Societal Importance of the Research Achievements |
本研究の成果により、個々の生体検体のデータ電位が簡便且つ精確に評価できるポータブルECMが実用化されれば、特に臨床医療の現場で、迅速な治療の開始・通院負担の軽減・医療費の抑制などの目的のため、患者の傍らで検体採取し、検査することによって直接的に検査結果が得られる、いわゆる「患者の傍らでの即時検査」POCT(Point of Care Testing)にも貢献する処、非常に大である。
|
Report
(4 results)
Research Products
(31 results)
-
-
-
-
[Journal Article] Chemical mist deposition of organic for efficient front- and back-PEDOT:PSS/crystalline Si heterojunction solar cells2019
Author(s)
ATMS. Islam, ME..Karim, A. Rajib, Y. Nasuno, T. Ukai, S. Kurosu, M. Tokuda, Y. Fujii, Y. Nakajima, T. Hanajiri, H. Shirai,
-
Journal Title
Applied Physics Letters
Volume: 114
Issue: 19
Pages: 193901-193901
DOI
Related Report
Peer Reviewed / Open Access
-
[Journal Article] Low-temperature synthesis of hydride semiconductor YH3-delta using Pt capped Y films and its chemical thermodynamics analysis2019
Author(s)
T. Sakai, M. Sakai, T. Kobayashi, M. Yasutake, S. Akisato, R. Mikami, N. Suganuma, Y.Takahashi, Y. Nakajima, M.Tokuda, Y.Fujii, T.Hanajiri
-
Journal Title
Thin Solid Films
Volume: 669
Pages: 288-293
DOI
Related Report
Peer Reviewed
-
-
-
-
-
[Journal Article] Barium hydroxide hole blocking layer for front- and back-organic/crystalline Si heterojunction solar cells2017
Author(s)
J. Hossain, K. Kasahara, D. Harada, A.T.M.Saiful Islam, R. Ishikawa, K. Ueno, T. Hanajiri, Y. Nakajima, Y. Fujii, M. Tokuda, H. Shirai
-
Journal Title
J. Appl. Phys.
Volume: 122
Issue: 5
Pages: 055101-055101
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
-
-
-
-
-
[Presentation] Stabiliza-tion and Control of the Ratio of YH3 to YH2 in Yttrium Hydride2019
Author(s)
T. Matsudo, J. Kaneko, Y. Tachalert, T. Fujino, Y. Nakajima, M. Tokuda, Y. Fujii, O. Nakamura, M. Sakai, T. Hanajiri
Organizer
ICMAT 10th International Conference on Materials for Advanced Technologies, (Marina Bay Sands, Singapore)
Related Report
Int'l Joint Research
-
-
[Presentation] PEDOT:PSS/n-Si heterojunction solar cells with ALD-Al2O3/n-Si field effect inversion layer2019
Author(s)
E. Karim, T. Ukai, D. Harada, A.T.M. Islam1, S. Kurosu, Y. Nakajima, Y. Fujii, M. Tokuda,, T. Hanajiri, R. Ishikawa, K. Ueno, H. Shirai
Organizer
6th Korea-Japan Joint Symposium on Advanced Solar Cells 2019
Related Report
Int'l Joint Research
-
-
-
-
-
-
-
-
-
-
[Presentation] Pt触媒を用いて作製した半導体相YH3のホール効果2018
Author(s)
菅沼 奈央, 佐藤 枢, 秋里 宗次郎, 三上 亮太, 高橋 侑太郎, 芦沢 優吾, 酒井 政道, 中村 修, 花尻 達郎, 中島 義賢, 徳田 正秀, 藤井 泰彦
Organizer
第65回応用物理学会春季学術講演会
Related Report
-
[Presentation] Pt触媒を用いた低濃度水素によるYの完全水素化2018
Author(s)
坂井 琢磨, 佐藤 枢, 三上 亮太, 菅沼 奈央, 秋里 宗次郎, 酒井 政道, 花尻 達郎, 中島 義賢, 徳田 正秀, 藤井 泰彦, 中村 修
Organizer
第65回応用物理学会春季学術講演会
Related Report
-
-
-
[Presentation] A New Scaling Parameter of FinFETs2017
Author(s)
S. Yamakawa, Y. Tanaka, Y. Osawa, T. Kawakita, H. Shimazu, Y. Nakajima, T. Yamada, T. Hanajiri
Organizer
The 12th International Conference on Surfaces, Coatings and Nanostructured Materials (NANOSMAT2017)
Related Report
Int'l Joint Research