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Development of a new quantitative diagnostic method for coronary artery vulnerable plaque by intravascular imaging

Research Project

Project/Area Number 17K01417
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Medical systems
Research InstitutionTohoku Medical and Pharmaceutical University (2018-2022)
Wakayama Medical University (2017)

Principal Investigator

Kameyama Takeyoshi  東北医科薬科大学, 医学部, 講師 (50761847)

Co-Investigator(Kenkyū-buntansha) 久保 隆史  和歌山県立医科大学, 医学部, 博士研究員 (30316096)
赤阪 隆史  和歌山県立医科大学, 医学部, 特別研究員 (70322584)
猪野 靖  和歌山県立医科大学, 医学部, 博士研究員 (00549793)
長岡 亮  富山大学, 学術研究部工学系, 准教授 (60781648)
Project Period (FY) 2017-04-01 – 2023-03-31
Project Status Completed (Fiscal Year 2022)
Budget Amount *help
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2019: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2018: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2017: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Keywords動脈硬化 / 不安定プラーク / 血管内イメージング / 光干渉断層法 / 近赤外線分光法 / 血管内超音波 / 急性冠症候群 / 急性心筋梗塞 / パラメトリックイメージング / 血管内光干渉断層法
Outline of Final Research Achievements

Early detection of vulnerable plaque that causes acute myocardial infarction is an important research theme. We compared intravascular imaging: Optical coherence tomography (OCT) and near-infrared spectroscopy/intravascular ultrasound (NIRS-IVUS) to develop a new diagnostic method for coronary vulnerable plaque. Although we were not able to develop a quantitative method for diagnosing arteriosclerosis by OCT, we could develop a new diagnostic algorithm for coronary atherosclerotic plaque by NIRS-IVUS. Our new algorithm using NIRS-IVUS can distinguish between plaque rupture, plaque erosion, and granular calcification on OCT.

Academic Significance and Societal Importance of the Research Achievements

NIRS-IVUSの新たな冠動脈プラーク判断アルゴリズムにより、プラーク破裂、プラークびらん、粒状石灰化の正確な鑑別が可能となった。これにより不安定な冠動脈病変を特定できるようになり、急性冠症候群(急性心筋梗塞および不安定狭心症)のより適切な治療法を選択できるようになる。

Report

(7 results)
  • 2022 Annual Research Report   Final Research Report ( PDF )
  • 2021 Research-status Report
  • 2020 Research-status Report
  • 2019 Research-status Report
  • 2018 Research-status Report
  • 2017 Research-status Report
  • Research Products

    (19 results)

All 2021 2020 2019 2018 2017 Other

All Int'l Joint Research (4 results) Journal Article (3 results) (of which Int'l Joint Research: 2 results,  Peer Reviewed: 3 results,  Open Access: 2 results) Presentation (10 results) (of which Int'l Joint Research: 2 results,  Invited: 2 results) Book (2 results)

  • [Int'l Joint Research] エラスムス大学胸部疾患セン ター 生体医工学教室(オランダ)

    • Related Report
      2020 Research-status Report
  • [Int'l Joint Research] エラスムス大学胸部疾患センター 生体医工学教室(オランダ)

    • Related Report
      2019 Research-status Report
  • [Int'l Joint Research] エラスムス大学胸部疾患セン ター 生体医工学教室(オランダ)

    • Related Report
      2018 Research-status Report
  • [Int'l Joint Research] エラスムス大学胸部疾患センター 生体医工学教室(オランダ)

    • Related Report
      2017 Research-status Report
  • [Journal Article] Target Lesion Lipid Content Detected by Near-Infrared Spectroscopy After Stenting and the Risk of Subsequent Target Lesion Failure2021

    • Author(s)
      Madder Ryan D.、Kubo Takashi、Ino Yasushi、Kameyama Takeyoshi、Terada Kosei、VanOosterhout Stacie、Mulder Abbey、McNamara Michael、Kenaan Mohamad、Samani Soroush、Kassier Adnan、Parker Jessica L.、McNamara Richard、Akasaka Takashi
    • Journal Title

      Arteriosclerosis, Thrombosis, and Vascular Biology

      Volume: 41 Issue: 7 Pages: 2181-2189

    • DOI

      10.1161/atvbaha.120.315617

    • Related Report
      2021 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] NIRS-IVUS for Differentiating Coronary Plaque Rupture, Erosion and Calcified Nodule in Acute Myocardial Infarction2020

    • Author(s)
      Kosei Terada, Takashi Kubo, Takeyoshi Kameyama, Yoshiki Matsuo, Yasushi Ino, Hiroki Emori, Daisuke Higashioka, Yosuke Katayama, Amir Kh.M. Khalifa, Masahiro Takahata, Kunihiro Shimamura, Yasutsugu Shiono, Atsushi Tanaka, Takeshi Hozumi, Ryan D. Madder, Takashi Akasaka
    • Journal Title

      JACC: Cardiovascular Imaging

      Volume: - Issue: 7 Pages: 30827-5

    • DOI

      10.1016/j.jcmg.2020.08.030

    • Related Report
      2020 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Clinical Utility of Combined Optical Coherence Tomography and Near-Infrared Spectroscopy for Assessing the Mechanism of Very Late Stent Thrombosis2018

    • Author(s)
      Ino Yasushi、Kubo Takashi、Kameyama Takeyoshi、Shimamura Kunihiro、Terada Kosei、Matsuo Yoshiki、Kitabata Hironori、Shiono Yasutsugu、Kashiwagi Manabu、Kuroi Akio、Maniwa Naoki、Ota Shingo、Ozaki Yuichi、Tanaka Atsushi、Hozumi Takeshi、Akasaka Takashi
    • Journal Title

      JACC: Cardiovascular Imaging

      Volume: 11 Issue: 5 Pages: 772-775

    • DOI

      10.1016/j.jcmg.2017.11.015

    • Related Report
      2018 Research-status Report
    • Peer Reviewed
  • [Presentation] NIRS-IVUS Guided PCI : Feasibility and Initial Results2021

    • Author(s)
      Takeyoshi Kameyama, Takao Nakano, Hisashi Kikuta, Yuki Kurose, Kaoru Hasegawa, Takenori Sumiyoshi, Yuko Sekiguchi, Minoru Yambe, Yoshinao Sugai, Koji Kumagai, Tatsuya Komaru
    • Organizer
      The 29th Annual Meeting of the Japanese Association of Cardiovascular Intervention and Therapeutics―CVIT 2020
    • Related Report
      2020 Research-status Report
  • [Presentation] A case of Lotus root-like appearance observed by OCT with unexpectedly low FFR value.2020

    • Author(s)
      Takeyoshi Kameyama, Takao Nakano, Hisashi Kikuta, Yuki Kurose, Kaoru Hasegawa, Takenori Sumiyoshi, Yuko Sekiguchi, Minoru Yambe, Yoshinao Sugai, Koji Kumagai, Tatsuya Komaru.
    • Organizer
      Asian Pacific Society of Cardiology Congress 2020 (APSC2020).
    • Related Report
      2019 Research-status Report
    • Int'l Joint Research
  • [Presentation] NIRS-IVUSガイド下で末梢塞栓を予測しニトロプルシドを冠注した1例2019

    • Author(s)
      亀山剛義、菊田 寿、中野陽夫、長谷川薫、住吉剛忠、関口祐子、山家 実、菅井義尚、熊谷浩司、小丸達也
    • Organizer
      第168回日本循環器学会東北地方会
    • Related Report
      2019 Research-status Report
  • [Presentation] FFR陰性のCAGから3ヶ月後に完全閉塞を来たし、NIRS-IVUSガイド下でPCIを施行した1例2019

    • Author(s)
      亀山剛義、菊田 寿、中野陽夫、黒瀬裕樹、長谷川薫、住吉剛忠、関口祐子、山家 実、菅井義尚、熊谷浩司、小丸達也
    • Organizer
      第46回日本心血管インターベンション治療学会東北地方会
    • Related Report
      2019 Research-status Report
  • [Presentation] Cypherステント留置後の再々狭窄をOCTと新型NIRS-IVUSでPCIした1例2019

    • Author(s)
      亀山剛義,菊田寿,中野陽夫,長谷川薫,住吉剛忠,関口祐子,山家実,菅井義尚,熊谷浩司,小丸達也
    • Organizer
      第45回日本心血管インターベンション学会東北地方会
    • Related Report
      2018 Research-status Report
  • [Presentation] 新型NIRS-IVUSの有用性2018

    • Author(s)
      亀山剛義
    • Organizer
      Imaging and Physiology Oriented PCI Live Demonstration Course 2018
    • Related Report
      2018 Research-status Report
    • Invited
  • [Presentation] 新型NIRS-IVUSの可能性2018

    • Author(s)
      亀山剛義
    • Organizer
      岩手リアルワールドライブ
    • Related Report
      2018 Research-status Report
    • Invited
  • [Presentation] OCTとNIRS-IVUSの組み合わせによる不安定プラークの同定に関する検討2018

    • Author(s)
      亀山剛義,久保隆史,猪野靖,松尾好記,北端宏規,嶋村邦宏,塩野泰紹,片山陽介,江守裕紀,寺田幸誠,赤阪隆史
    • Organizer
      第66回日本心臓病学会学術集会
    • Related Report
      2018 Research-status Report
  • [Presentation] 血管内イメージングについて- OCTとNIRS-IVUSの有用性 -2018

    • Author(s)
      亀山剛義
    • Organizer
      第34回東北心臓疾患研究会
    • Related Report
      2018 Research-status Report
  • [Presentation] NIRS-IVUS guided PCI: Successful and unsuccessful cases.2017

    • Author(s)
      Kameyama T, Kubo T, Akasaka T.
    • Organizer
      Optics in cardiology 2017, 2017.4, Rotterdam, The Netherlands
    • Related Report
      2017 Research-status Report
    • Int'l Joint Research
  • [Book] 新しいNIRS-IVUSとその有用性. 特集PCIにおけるIVUS/OCTの活かし方2018前編, Coronary intervention 14 (2): 63-69, 2018.2018

    • Author(s)
      亀山剛義, 久保隆史
    • Total Pages
      7
    • Publisher
      株式会社メディアルファ、東京
    • Related Report
      2017 Research-status Report
  • [Book] 近赤外線スペクトロスコピー. 循環器内科. 2017;81:5796-5799.2017

    • Author(s)
      亀山剛義, 久保隆史, 赤阪隆史.
    • Total Pages
      4
    • Publisher
      科学評論社、東京
    • Related Report
      2017 Research-status Report

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Published: 2017-04-28   Modified: 2024-01-30  

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