Development of a new quantitative diagnostic method for coronary artery vulnerable plaque by intravascular imaging
| Project/Area Number |
17K01417
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Medical systems
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| Research Institution | Tohoku Medical and Pharmaceutical University (2018-2022)
Wakayama Medical University (2017) |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
久保 隆史 和歌山県立医科大学, 医学部, 博士研究員 (30316096)
赤阪 隆史 和歌山県立医科大学, 医学部, 特別研究員 (70322584)
猪野 靖 和歌山県立医科大学, 医学部, 博士研究員 (00549793)
長岡 亮 富山大学, 学術研究部工学系, 准教授 (60781648)
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| Project Period (FY) |
2017-04-01 – 2023-03-31
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| Project Status |
Completed (Fiscal Year 2022)
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| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2019: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2018: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2017: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
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| Keywords | 動脈硬化 / 不安定プラーク / 血管内イメージング / 光干渉断層法 / 近赤外線分光法 / 血管内超音波 / 急性冠症候群 / 急性心筋梗塞 / パラメトリックイメージング / 血管内光干渉断層法 |
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| Outline of Final Research Achievements |
Early detection of vulnerable plaque that causes acute myocardial infarction is an important research theme. We compared intravascular imaging: Optical coherence tomography (OCT) and near-infrared spectroscopy/intravascular ultrasound (NIRS-IVUS) to develop a new diagnostic method for coronary vulnerable plaque. Although we were not able to develop a quantitative method for diagnosing arteriosclerosis by OCT, we could develop a new diagnostic algorithm for coronary atherosclerotic plaque by NIRS-IVUS. Our new algorithm using NIRS-IVUS can distinguish between plaque rupture, plaque erosion, and granular calcification on OCT.
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| Academic Significance and Societal Importance of the Research Achievements |
NIRS-IVUSの新たな冠動脈プラーク判断アルゴリズムにより、プラーク破裂、プラークびらん、粒状石灰化の正確な鑑別が可能となった。これにより不安定な冠動脈病変を特定できるようになり、急性冠症候群（急性心筋梗塞および不安定狭心症）のより適切な治療法を選択できるようになる。
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Report
(7 results)
Research Products
(19 results)
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[Journal Article] NIRS-IVUS for Differentiating Coronary Plaque Rupture, Erosion and Calcified Nodule in Acute Myocardial Infarction2020
Author(s)
Kosei Terada, Takashi Kubo, Takeyoshi Kameyama, Yoshiki Matsuo, Yasushi Ino, Hiroki Emori, Daisuke Higashioka, Yosuke Katayama, Amir Kh.M. Khalifa, Masahiro Takahata, Kunihiro Shimamura, Yasutsugu Shiono, Atsushi Tanaka, Takeshi Hozumi, Ryan D. Madder, Takashi Akasaka
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Journal Title
JACC: Cardiovascular Imaging
Volume: -
Issue: 7
Pages: 30827-5
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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[Presentation] NIRS-IVUS Guided PCI : Feasibility and Initial Results2021
Author(s)
Takeyoshi Kameyama, Takao Nakano, Hisashi Kikuta, Yuki Kurose, Kaoru Hasegawa, Takenori Sumiyoshi, Yuko Sekiguchi, Minoru Yambe, Yoshinao Sugai, Koji Kumagai, Tatsuya Komaru
Organizer
The 29th Annual Meeting of the Japanese Association of Cardiovascular Intervention and Therapeutics―CVIT 2020
Related Report
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[Presentation] A case of Lotus root-like appearance observed by OCT with unexpectedly low FFR value.2020
Author(s)
Takeyoshi Kameyama, Takao Nakano, Hisashi Kikuta, Yuki Kurose, Kaoru Hasegawa, Takenori Sumiyoshi, Yuko Sekiguchi, Minoru Yambe, Yoshinao Sugai, Koji Kumagai, Tatsuya Komaru.
Organizer
Asian Pacific Society of Cardiology Congress 2020 (APSC2020).
Related Report
Int'l Joint Research
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[Presentation] OCTとNIRS-IVUSの組み合わせによる不安定プラークの同定に関する検討2018
Author(s)
亀山剛義,久保隆史,猪野靖,松尾好記,北端宏規,嶋村邦宏,塩野泰紹,片山陽介,江守裕紀,寺田幸誠,赤阪隆史
Organizer
第66回日本心臓病学会学術集会
Related Report
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