Multimodal imaging of cancerous regions utilizing spectral X-ray CT and 7T-MRI
Project/Area Number |
17K01424
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Medical systems
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Research Institution | Toho University |
Principal Investigator |
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Project Period (FY) |
2017-04-01 – 2020-03-31
|
Project Status |
Completed (Fiscal Year 2019)
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Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2019: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2018: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2017: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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Keywords | X線CT / CdTe検出器 / フォトンカウンティング / CdTeアレー / スペクトラルCT / 7T-MRI / ナノ粒子懸濁液 / 陰性造影剤 / スペクトラルX線CT / トリプルエネルギーCT / ビームハードニングCT / 3次元イメージング / ブドウ糖 / ガドペント酸メグルミン / 酸化ガドリニウム / T2強調画像 / トリプルエネルギーCTスキャナー / クアッドエネルギーCT / KエッジCT / マルチモーダルイメージング / エネルギー弁別X線CT / Gd-KエッジCT / 画像診断システム |
Outline of Final Research Achievements |
To visualize cancerous region utilizing enhanced K-edge angiography using I and Gd media, we developed both the first- and third-generation X-ray spectral CT (SP-CT) scanners. The spatial resolutions of the first and third scanners were 0.25 and 0.1mm, respectively, and fine blood vessels were observed at high contrasts. Using 7T-MRI and T2*WI, we carried out cancer-region visualization using Gd2O3-nanoperticle suspension. The nanoparticles remained effectively in the rabbit-thigh cancer utilizing femoral-vein injection, and the gray-value density in the cancer substantially decreased. In the infusion of the nanoparticle suspension from a rabbit ear, a negative contrast effect in the cancerous region was observed immediately after the infusion.
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Academic Significance and Societal Importance of the Research Achievements |
本研究ではフォトンカウンティングを利用したスペクトラルX線CTと7T-MRIの医療診断における先端技術を取り入れて,さらに新しい技術の開発を試みた。第1世代CTではデュアル,トリプル,クアッドエネルギーのスキャナーが開発され,撮影エネルギー範囲を変化させることにより,血管のコントラストが著しく変化した。第3世代では空間分解能が0.1mm程度まで改善され,3D-CTも実現された。一方,7T-MRIでは陰性造影剤としての酸化ガドリニウムナノ粒子懸濁液が開発され,造影効果が確認された。磁性ナノ粒子はハイパーサーミアにも利用できることから,癌治療への応用も期待される。
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Report
(4 results)
Research Products
(52 results)
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[Journal Article] Triple-sensitivity high-spatial-resolution X-ray computed tomography using a cadmium-telluride detector and its beam-hardening effect2020
Author(s)
Yoshida, S., Sato, E., Oda, Y., Yoshioka, K., Moriyama, H., Watanabe, M.
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Journal Title
Appl. Radiat. Isot.
Volume: 159
Pages: 109089-109089
DOI
Related Report
Peer Reviewed
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[Journal Article] Near-infrared-ray computed tomography with 850-nm peak and high spatial resplutions in first living-body window2019
Author(s)
Sato, E., Yoshida, A., Someya. T., Oda, Y., Yoshida, S., Yoshioka, K., Sato, Y., Moriyama, H., Watanabe, M.
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Journal Title
Phys. Open
Volume: 2
Pages: 100010-100010
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Near-infrared-ray computed tomography with 850-nm peak and high spatial resolutions2019
Author(s)
Sato, E., Yoshida, A., Someya. T., Yoshizawa, T., Morimoto, M., Mine, T., Oda, Y., Yoshida, S., Yoshioka, K., Sato, Y.
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Journal Title
Ann. Rep. Iwate Med. Univ. Center Lib. Arts Sci.
Volume: 54
Pages: 1-8
Related Report
Peer Reviewed
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[Journal Article] Measurement of penetrating photon spectra using a white power light-emitting diode2019
Author(s)
Sato, E., Oda, Y., Yoshida, S., Yoshioka, K., Moriyama, H., Hagiwara, O., Enomoto, T., Watanabe, M.
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Journal Title
Ann. Rep. Iwate Med. Univ. Center Lib. Arts Sci.
Volume: 54
Pages: 9-12
NAID
Related Report
Peer Reviewed
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[Journal Article] Investigation of low-dose energy-dispersive x-ray computed tomography utilizing beam hardening2019
Author(s)
Yoshida, S., Sato, E., Oda, Y., Yoshioka, S., Ehara, S., Moriyama, H., Hagiwara, O., Enomoto, T., Watanabe, M.
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Journal Title
Proc. SPIE
Volume: 11114
Pages: 55-55
DOI
Related Report
Int'l Joint Research
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[Journal Article] Intense nickel-K-photon irradiation from weakly-ionized linear plasma x-ray source with a reflector2019
Author(s)
Sato, E., Sato, Y., Yoshida, S., Yoshioka, K., Moriyama, H., Watanabe, M.
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Journal Title
Proc. SPIE
Volume: 11114
Pages: 52-52
DOI
Related Report
Int'l Joint Research
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[Journal Article] Photon-counting x-ray computed tomography using a YAP(Ce)-PMT detector and beam hardening2019
Author(s)
Watanabe, M., Sato, E., Yoshida, S., Yoshioka, K., Oda, Y., Moriyama, H., Hagiwara, O., Enomoto, T.
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Journal Title
Proc. SPIE
Volume: 11114
Pages: 51-51
DOI
Related Report
Int'l Joint Research
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[Journal Article] Measurement of humanbody-window spectra using a white power light-emitting diode and its application to high-spatial-resolution computed tomography2019
Author(s)
Moriyama, H., Sato, E., Oda, Y., Yoshida, S., Hagiwara, O., Enomoto, T., Watanabe, M.
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Journal Title
Proc. SPIE
Volume: 11073
Pages: 74-74
DOI
Related Report
Int'l Joint Research
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[Journal Article] 850-nm near-infrared-ray computed tomography with high spatial resolutions2019
Author(s)
Sato, E., Oda, Y., Sato, Y., Yoshida, S., Moriyama, H., Watanabe, M.
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Journal Title
Proc. SPIE
Volume: 11073
Pages: 22-22
DOI
Related Report
Int'l Joint Research
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[Journal Article] High-speed dual-energy x-ray photoncounter using a YAP(Ce)-photomultiplier detector and itsapplication to low-dose computedtomography2019
Author(s)
Sato, Y., Sato, E., Oda, Y., Moriyama, H., Hagiwara, O., Matsukiyo, H., Enomoto, T., Watanabe, M., Kusachi, S.
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Journal Title
Proc. SPIE
Volume: 11051
Pages: 19-19
DOI
Related Report
Int'l Joint Research
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[Journal Article] Dual-energy x-ray computed tomography scanner using a room-temperature cadmium-telluride detector and a range-region counter2018
Author(s)
8)Watanabe, M., Sato, E., Oda, Y., Yoshida, S., Moriyama, H., Hagiwara, O., Matsukiyo, H., Enomoto, T., Kusachi, S.
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Journal Title
SPIE 10763
Volume: 10763
Pages: 1-1
DOI
Related Report
Int'l Joint Research
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[Journal Article] Zero-dark-counting brief measurement of X-ray spectra using a lutetium-oxyorthosilicate multipixel-photon detector driven in pre-Geiger mode.2018
Author(s)
Enomoto, T., Sato, E., Moriyama, H., Hagiwara, O., Matsukiyo, H., Watanabe, M., Kusachi, S.
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Journal Title
Int. J. Sci. Res
Volume: 7
Pages: 1751-1756
Related Report
Peer Reviewed
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[Journal Article] Dual-energy low-dose X-ray computed tomography scanner using a room-temperature cadmium telluride detector.2018
Author(s)
Watanabe, M., Sato, E., Moriyama, H., Hagiwara, O., Matsukiyo, H., Enomoto, T., Kusachi, S.
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Journal Title
Int. J. Sci. Res.
Volume: 7
Pages: 184-189
Related Report
Peer Reviewed
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[Journal Article] Development of an amplifier module for measuring X-ray spectra using a photomultiplier tube.2018
Author(s)
Sato, E., Oda, Y., Sagae, M., Yoshida, S., Yamaguchi, S., Sato, Y., Moriyama, H., Hagiwara, O., Matsukiyo, H., Enomoto, T., Watanabe, M., Kusachi, S.
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Journal Title
Ann. Rep. Iwate Med. Univ. Center Lib. Arts Sci.
Volume: 53
Pages: 1-6
NAID
Related Report
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[Journal Article] High-sensitivity compact dosimeter using two silicon X-ray diode.2018
Author(s)
Sato, E., Oda, Y., Sagae, M., Yoshida, S., Yamaguchi, S., Sato, Y., Moriyama, H., Hagiwara, O., Matsukiyo, H., Enomoto, T., Watanabe, M., Kusachi, S.
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Journal Title
Ann. Rep. Iwate Med. Univ. Center Lib. Arts Sci.
Volume: 53
Pages: 7-12
NAID
Related Report
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[Journal Article] Development of a compact dosimeter using a silicon X-ray diode and a long USB cable.2017
Author(s)
Sato E, Oda Y, Sagae M, Yoshida S, Yamaguchi S, Sato Y, Moriyama H, Hagiwara O, Matsukiyo H, Enomoto T, Watanabe M, Kusachi S
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Journal Title
Ann. Rep. Iwate Med. Univ. Center Lib. Arts Sci.
Volume: 51
Pages: 1-5
NAID
Related Report
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[Journal Article] Measurement of X-ray spectra using a photomultiplier tube in conjunction with a simple inverse amplifier.2017
Author(s)
Sato E, Oda Y, Sagae M, Yoshida S, Yamaguchi S, Sato Y, Moriyama H, Hagiwara O, Matsukiyo H, Enomoto T, Watanabe M, Kusachi S
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Journal Title
Ann. Rep. Iwate Med. Univ. Center Lib. Arts Sci.
Volume: 51
Pages: 7-12
NAID
Related Report
-
[Presentation] Investigation of low-dose energy-dispersive x-ray computed tomography utilizing beam hardening2019
Author(s)
Yoshida, S., Sato, E., Oda, Y., Yoshioka, S., Ehara, S., Moriyama, H., Hagiwara, O., Enomoto, T., Watanabe, M.
Organizer
SPIE Optics+Photonics, San Diego
Related Report
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[Presentation] Intense nickel-K-photon irradiation from weakly-ionized linear plasma x-ray source with a reflector2019
Author(s)
Sato, E., Sato, Y., Yoshida, S., Yoshioka, K., Moriyama, H., Watanabe, M.
Organizer
SPIE Optics+Photonics, San Diego
Related Report
-
[Presentation] Photon-counting x-ray computed tomography using a YAP(Ce)-PMT detector and beam hardening2019
Author(s)
Watanabe, M., Sato, E., Yoshida, S., Yoshioka, K., Oda, Y., Moriyama, H., Hagiwara, O., Enomoto, T.
Organizer
SPIE Optics+Photonics, San Diego
Related Report
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[Presentation] 850-nm near-infrared-ray computed tomography with high spatial resolutions2019
Author(s)
Sato, E., Oda, Y., Sato, Y., Yoshida, S., Moriyama, H., Watanabe, M.
Organizer
European Conferences on Biomedical Optics, Munich.
Related Report
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[Presentation] Measurement of human-body-window spectra using a white power light-emitting diode and its application to high-spatial-resolution computed tomography2019
Author(s)
Moriyama, H., Sato, E., Oda, Y., Yoshida, S., Hagiwara, O., Enomoto, T., Watanabe, M.
Organizer
European Conferences on Biomedical Optics, Munich.
Related Report
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[Presentation] 850-nm-peak high-spatial-resolution near-infrared-ray computed tomography in the living-body window.2018
Author(s)
Sato, E. Oda, Y., Sato, Y., Moriyama, H., Hagiwara, O., Matsukiyo, H., Enomoto, T., Watanabe, M., Kusachi, S.
Organizer
Asia-Oceania Congress on Medical Physics
Related Report
Int'l Joint Research
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[Presentation] Low-dose tripe-energy X-ray computed tomography using a cadmium telluride detector with high-spatial and -energy resolutions.2018
Author(s)
Sato, E. Oda, Y., Sato, Y., Moriyama, H., Hagiwara, O., Matsukiyo, H., Enomoto, T., Watanabe, M., Kusachi, S.
Organizer
Asia-Oceania Congress on Medical Physics
Related Report
Int'l Joint Research
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[Presentation] Intense nickel-K-photon irradiation from weakly-ionized linear plasma X-ray source with a zinc reflector.2018
Author(s)
Sato, E., Oda, Y., Sato, Y., Morikaya, H., Hagiwara, O., Matsukiyo, H., Enomoto, T., Watanabe, M., Kusachi, S.
Organizer
32nd Int. Congr. High-Speed Imaging and Photonics
Related Report
Int'l Joint Research
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[Presentation] High-speed tripe-energy X-ray photon counter using a room-temperature cadmium-telluride detector and its application to high-spatial-resolution low-dose computed tomography.2018
Author(s)
Watanabe, M., Sato, E., Oda, Y., Sato, Y., Yamaguchi, S., Moriyama, H., Hagiwara, O., Matsukiyo, H., Enomoto, T., Kusachi, S.
Organizer
32nd Int. Congr. High-Speed Imaging and Photonics
Related Report
Int'l Joint Research
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[Presentation] High-speed dual-energy X-ray photon counter using a YAP(Ce)-photomultiplier detector and its application to low-dose computed tomography.2018
Author(s)
Sato, Y., Sato, E., Oda, Y., Moriyama, H., Hagiwara, O., Matsukiyo, H., Enomoto, T., Watanabe, M., Kusachi, S.
Organizer
32nd Int. Congr. High-Speed Imaging and Photonics
Related Report
Int'l Joint Research
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[Presentation] Dual-energy X-ray computed tomography scanner using a room-temperature cadmium-telluride detector and a range-region counter.2018
Author(s)
Watanabe, M., Sato, E., Oda, Y., Yoshida, S., Moriyama, H., Hagiwara, O., Matsukiyo, H., Enomoto, T., Kusachi, S.
Organizer
SPIE Optics+Photonics
Related Report
Int'l Joint Research
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[Presentation] Triple-energy high-count-rate X-ray computed tomography scanner using a cooled cadmium-telluride detector.2018
Author(s)
Moriyama, H., Sato, E., Oda, Y., Sato, Y., Yoshida, S., Yamaguchi, S., Hagiwara, O., Matsukiyo, H., Enomoto, T., Watanabe, M., Kusachi, S.
Organizer
SPIE Optics+Photonics
Related Report
Int'l Joint Research
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[Presentation] Dual-energy high-count-rate X-ray computed tomography using a cerium-doped yttrium-aluminum-perovskite crystal and a photomultiplier tube.2018
Author(s)
Sato, E., Oda, Y., Yoshida, S., Yamaguchi, S., Sato, Y., Moriyama, H., Hagiwara, O., Matsukiyo, H., Enomoto, T., Watanabe, M., Kusachi, S.
Organizer
SPIE Optics+Photonics
Related Report
Int'l Joint Research
-
[Presentation] 850-nm-peak high-sensitivity near-infrared-ray computed tomography scanner in the living-body window.2018
Author(s)
Sato, Y., Takaoka, A., Sato, T., Sato, E., Oda, Y., Yoshida, S., Moriyama, H., Hagiwara, O., Matsukiyo, H., Enomoto, T., Watanabe, M., Kusachi, S.
Organizer
17th Asia Oceania Congress of Medical Physics,
Related Report
Int'l Joint Research
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[Presentation] Triple-energy high-count-rate X-ray computed tomography scanner using a cadmium telluride detector.2018
Author(s)
Sato, E., Sato, T., Oda, Y., Sato, Y., Yoshida, S., Yamaguchi, S., Hagiwara, O., Matsukiyo, H., Enomoto, T., Watanabe, M., Kusachi, S.
Organizer
17th Asia Oceania Congress of Medical Physics,
Related Report
Int'l Joint Research
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[Presentation] Dual-energy high-count-rate X-ray computed tomography scanner using a cerium-doped yttrium aluminum perovskite crystal and a small-photomultiplier tube.2018
Author(s)
Sato, T., Sato, E., Oda, Y., Sato, Y., Yoshida, S., Yamaguchi, S., Hagiwara, O., Matsukiyo, H., Enomoto, T., Watanabe, M., Kusachi, S.
Organizer
17th Asia Oceania Congress of Medical Physics,
Related Report
Int'l Joint Research
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[Presentation] Measurement of x-ray spectra using a recent YAP(Ce)-MPPC detector.2017
Author(s)
Sato, E., Oda, Y., Yoshida, S., Yamaguchi, S., Sato, Y., Ishii, T., Hagiwara, O., Matsukiyo, H., Enomoto, T., Watanabe, M., Kusachi, S.
Organizer
SPIE Optics+Photonics.
Related Report
Int'l Joint Research
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[Presentation] Investigation of a high-sensitivity near-infrared-ray computed tomography scanner.2017
Author(s)
Sato, E., Oda, Y., Yoshida, S., Yamaguchi, S., Sato, Y., Ishii, T., Hagiwara, O., Matsukiyo, H., Enomoto, T., Watanabe, M., Kusachi, S.
Organizer
SPIE Optics+Photonics.
Related Report
Int'l Joint Research
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