Development of Microfluidic Devices for Circulating Tumor Cell Separation
| Project/Area Number |
17K01432
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Medical systems
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| Research Institution | Toyama Industrial Technology Research and Development Center |
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Principal Investigator |
TAKATA Koji 富山県産業技術研究開発センター, その他部局等, 主任研究員 (40530621)
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| Co-Investigator(Kenkyū-buntansha) |
横堀 武彦 群馬大学, 未来先端研究機構, 准教授 (60420098)
安田 佳織 富山県立大学, 工学部, 講師 (70707231)
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| Project Period (FY) |
2017-04-01 – 2020-03-31
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| Project Status |
Completed (Fiscal Year 2019)
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| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2019: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2018: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2017: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Keywords | 循環がん細胞 / がん / マイクロ流路チップ / 低侵襲治療システム / 癌 |
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| Outline of Final Research Achievements |
Circulating tumor cells (CTC) are tumor-derived cells circulating in bloodstream and could be the origin of lethal metastatic disease. Easy-to-use and high-throughput methods for CTC separation have potential to be used in innovative cancer therapy, next-generation diagnosis, personalized medicine, fundamental metastasis research, etc. In this study, we newly developed a microfluidic device which could easily separate CTCs, and devices which could be used for high-throughput cell separation. These devices were tested using blood sample spiked with cultured cancer cells, and we showed that the devices could successfully separate cultered cancer cells.
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| Academic Significance and Societal Importance of the Research Achievements |
これまで開発してきたマイクロ流路チップをベースに、簡便に、かつ、大量の血液からCTCを分離する方法を開発する研究である。大量の血液からCTCが分離できるようになれば、転移を抑える革新的ながん治療等に繋がると考えられる。また、血液からCTCを分離・回収することもできるため、これまでCTCが希少なため困難であったCTCによる癌の状態のモニタリング、最適な治療法の選択等にも用いることができ、がん医療に多大な貢献ができると考えられる。
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Report
(4 results)
Research Products
(6 results)
