| Project/Area Number |
17K01453
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Rehabilitation science/Welfare engineering
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| Research Institution | Dokkyo Medical University (2018-2019)
Hokkaido University (2017) |
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Principal Investigator |
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| Project Period (FY) |
2017-04-01 – 2020-03-31
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| Project Status |
Completed (Fiscal Year 2019)
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| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2019: ¥390,000 (Direct Cost: ¥300,000、Indirect Cost: ¥90,000)
Fiscal Year 2018: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2017: ¥3,250,000 (Direct Cost: ¥2,500,000、Indirect Cost: ¥750,000)
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| Keywords | 経頭蓋電気刺激 / ヒト歩行 / 歩行障害 / 脳卒中 / 経頭蓋律動電流刺激 / リハビリテーション / 歩行 / 非侵襲的脳刺激 |
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| Outline of Final Research Achievements |
As for healthy subjects, each subject received anodal transcranial patterned direct current stimulation over the foot area of the motor cortex during gait. Self-paced gait speed and left leg stride length were significantly increased and a significant increase was found in the excitability of the corticospinal pathway of the left tibialis anterior muscle. As for patients, we investigated whether gait-synchronized rhythmic brain stimulation targeting swing phase-related M1 activity can improve gait function in post-stroke patients in the chronic phase. The brain stimulation was synchronized with individual gait rhythm. After we administered the intervention repeatedly, self- and maximally-paced gait speed and timed up and go test (TUG) performance were significantly improved along with improved balance function and increased joint flexion of the paretic limbs during gait.
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| Academic Significance and Societal Importance of the Research Achievements |
これまで、歩行中の脳律動に着目し律動性脳刺激を行った研究報告はなく、新たな脳刺激法による歩行障害の治療法の開発につながる成果となった。今後はさらに刺激法と歩行訓練法について検討を行い、車椅子での生活を余儀なくされている多くの患者において歩行機能を再建することで、生活の質(QOL)、日常生活能力(ADL)の向上をめざしていくこととなる。また、ヒトにおける歩行機能再建に関わる神経経路の一部を解明することができたため、機能再建に役立つばかりでなく、機能代替としてより効率的な義足・下肢装具の開発のための基礎技術につながる。
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