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The effect of voluntary muscle contraction on spinal cord excitability and its application for rehabilitation medicine

Research Project

Project/Area Number 17K01461
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Rehabilitation science/Welfare engineering
Research InstitutionTeikyo University (2020)
Saitama Medical University (2018-2019)
Saitama Prefectural University (2017)

Principal Investigator

HARA MOTOHIKO  帝京大学, 医学部, 教授 (30386007)

Project Period (FY) 2017-04-01 – 2021-03-31
Project Status Completed (Fiscal Year 2020)
Budget Amount *help
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2019: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2018: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2017: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Keywords脊髄興奮性 / F波 / 経頭蓋直流電気刺激 / リハビリテーション医学
Outline of Final Research Achievements

We examined the effect on ulnar F-wave persistence and amplitude which indicated spinal cord excitability by neck rotation, neck anterior flexion and teeth clenching. We examined the effect of motor imagery (MI) and voluntary muscle contraction (VC) of teeth clinching on the persistence and amplitude of F-waves recorded from the FDI before and immediately after transcranial direct stimulation (tDCS). Neck rotation and anterior flexion showed that F wave persistence and amplitude are increased at rest from VC respectively. Both motor imagery and VC of teeth clenching enhanced F-wave persistence and amplitude of FDI. The anodal tDCS had no influence on such excitability change. In conclusion, our studies show that spinal cord excitability may enhance by MI and VC of different part. Farther discussion needs for the effect of anodal tDCS for motor tasks and spinal cord excitability in F-wave study.

Academic Significance and Societal Importance of the Research Achievements

今回の研究では、脊髄興奮性の指標の一つであるF波が、F波を記録しているのとは異なる筋の軽度の随意収縮や運動想起を行うことで尺骨神経を刺激して第一背側骨間筋から記録したF波の出現率と振幅が安静時に較べてどのように変化するかを検討した。頚部の回旋、前屈、Teeth clenchingのいずれにおいてもF波の出現率と振幅が安静時に較べて運動想起と軽度随意収縮を行うことによって増加する所見を認めた。この結果はギプス固定などで上肢の安静を余儀なくされる状態および下位頚髄損傷の状態でも、頚部と咬筋の運動想起と軽度随意的筋収縮により異なる髄節支配部位の脊髄興奮性を維持できる可能性を示唆している。

Report

(5 results)
  • 2020 Annual Research Report   Final Research Report ( PDF )
  • 2019 Research-status Report
  • 2018 Research-status Report
  • 2017 Research-status Report
  • Research Products

    (11 results)

All 2021 2020 2019 2018 2017

All Journal Article (7 results) (of which Peer Reviewed: 7 results,  Open Access: 6 results) Presentation (4 results) (of which Int'l Joint Research: 2 results,  Invited: 1 results)

  • [Journal Article] Mobility performance impacts mortality risk in community-dwelling healthy older adults in Japan: a prospective observational study.2021

    • Author(s)
      Otsuka H, Kobayashi H, Suzuki K, Hayashi Y, Ikeda J, Kushimoto M, Hara M, Abe M, Kato K, Soma M.
    • Journal Title

      Aging Clin Exp Res

      Volume: - Issue: 9 Pages: 2511-2517

    • DOI

      10.1007/s40520-021-01787-1

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Mobility performance among healthy older adults eligible for long-term care in Japan: a prospective observational study.2020

    • Author(s)
      Otsuka H, Kobayashi H, Suzuki K, Hayashi Y, Ikeda J, Kushimoto M, Omoto W, Hara M, Abe M, Kato K, Soma M
    • Journal Title

      Aging Clin Exp Res.

      Volume: 32 Issue: 10 Pages: 791-798

    • DOI

      10.1007/s40520-019-01404-2

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Adiponectin Receptor gene Polymorphisms are Associated with Kidney Function in Elderly Japanese Populations2019

    • Author(s)
      Kobayashi H, Otsuka H, Yanai M, Hara M, Hishiki M, Soma M, Abe M
    • Journal Title

      Journal of Atherosclerosis and Thrombosis

      Volume: 26 Issue: 4 Pages: 328-339

    • DOI

      10.5551/jat.45609

    • NAID

      130007621866

    • ISSN
      1340-3478, 1880-3873
    • URL

      https://pure.teikyo.jp/en/publications/3b4c88e3-0be5-430c-8b47-9894f2e139fd

    • Year and Date
      2019-04-01
    • Related Report
      2019 Research-status Report
    • Peer Reviewed
  • [Journal Article] F波とは,生理学的機序と脊髄興奮性2018

    • Author(s)
      原 元彦
    • Journal Title

      臨床神経生理学

      Volume: 46 Pages: 168-174

    • NAID

      130007429186

    • Related Report
      2018 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] High-molecular-weight adiponectin levels in healthy, community-dwelling, elderly Japanese volunteers: a 5-year prospective observational study2018

    • Author(s)
      Otsuka H, Yanai M, Kobayashi H, Haketa A, Hara M, Sugama K, Kato K, Soma M.
    • Journal Title

      Aging Clin Exp Res

      Volume: 30 Issue: 7 Pages: 791

    • DOI

      10.1007/s40520-017-0840-6

    • URL

      https://pure.teikyo.jp/en/publications/ee67b928-f9bd-4935-9802-63559c27ab26

    • Related Report
      2018 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Adiponectin is not associated with renal function decline in community-dwelling elderly adults2018

    • Author(s)
      Kobayashi H, Otsuka H, Yanai M, Haketa A, Hara M, Hishiki M, Abe M, Soma M.
    • Journal Title

      Medicine (Baltimore).

      Volume: 97 Issue: 21 Pages: e10847-e10847

    • DOI

      10.1097/md.0000000000010847

    • URL

      https://pure.teikyo.jp/en/publications/9cf516f6-7323-4b67-bf01-2bcf7c6e10e2

    • Related Report
      2018 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Anxiety, fatigue, and attentional bias toward threat in patients with hematopoietic tumors2018

    • Author(s)
      Kohei Koizumi, Jun Tayama, Toshiyuki Ishioka, Hiromi Nakamura-Thomas, Makoto Suzuki, Motohiko Hara, Shigeru Makita, Toyohiro Hamaguchi
    • Journal Title

      Pros One

      Volume: 13 Issue: 2 Pages: 1-13

    • DOI

      10.1371/journal.pone.0192056

    • URL

      https://localhost/en/publications/0d1c2920-8188-443d-923a-870ff657467a

    • Related Report
      2018 Research-status Report
    • Peer Reviewed / Open Access
  • [Presentation] F wave as a measure of distant motoneuron excitability changes induced by motor imagery and voluntary muscle contraction of teeth clinching before and after transcranial direct current stimulation.2019

    • Author(s)
      Hara M,Thomas-Nakamura H, Sato K, Oki S, Aso Y, Maeda K, Majima M, Kurabayashi H, Kimura J
    • Organizer
      American Clinical Neurophysiology Society (ACNS) Annual Meeting
    • Related Report
      2019 Research-status Report
  • [Presentation] Voluntary Neck Rotation Enhances Ulnar Nerve F-Wave2019

    • Author(s)
      Hara M, Kawakami S, Ohishi E, Thomas-Nakamura H, Maeda K, Yamanouchi Y, Majima M, Kurabayashi H, Kimura J:
    • Organizer
      2019 Annual Meeting of ISPRM
    • Related Report
      2019 Research-status Report
    • Int'l Joint Research
  • [Presentation] F wave as a measure of distant motoneuron excitability changes induced by motor imagery and voluntary muscle contraction of teeth clinching before and after transcranial direct current stimulation.2019

    • Author(s)
      Hara M, Thomas-Nakamura H, Sato K, Oki S, Aso Y. Maeda K, Majima M, Kurabayashi H, Kimura J
    • Organizer
      Annual Meeting, American Clinical Neurophysiology Society (ACNS)
    • Related Report
      2018 Research-status Report
    • Int'l Joint Research
  • [Presentation] F波と脊髄興奮性2017

    • Author(s)
      原 元彦
    • Organizer
      第47回日本臨床神経生理学会学術集会
    • Related Report
      2017 Research-status Report
    • Invited

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Published: 2017-04-28   Modified: 2022-01-27  

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