Exercise increases neural stem cell number around the area of damage following rat traumatic brain injury

• Project/Area Number: 17K01486
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Rehabilitation science/Welfare engineering
• Research Institution: Kindai University
• Principal Investigator: Itoh Tatsuki 近畿大学, 農学部, 教授 (40330245)
• Co-Investigator(Kenkyū-buntansha): 井上 敬夫 近畿大学, 医学部, 助教 (00441006) ; 佐藤 隆夫 近畿大学, 大学病院, 教授 (70162443)
• Project Period (FY): 2017-04-01 – 2020-03-31
• Project Status: Completed (Fiscal Year 2019)
• Budget Amount: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000); Fiscal Year 2019: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2018: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2017: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
• Keywords: 脳外傷 / 運動 / 神経再生 / リハビリテーション / リハビリ / 適切な運動開始日 / neurogenesis / 最適な運動開始日 / 最適な開始日 / 開始時の違い

Outline of Final Research Achievements

From our current study, we propose that the exercise in the early following traumatic brain injury increases the number of nestin-positive cells-including NSCs- with the potential to differentiate into neurons and glia around the area damaged by TBI, and enhanced proliferation activity of neural stem cells (NSCs) around damaged area after traumatic brain injury(TBI). Therefore, the exercise therapy (rehabilitation) in the early phase following TBI is very important for recuperation of induced cerebral dysfunction following TBI.

Academic Significance and Societal Importance of the Research Achievements

脳外傷後早期から運動（リハビリテーション）をすることは脳損傷後における損傷部位での神経幹細胞の増殖能力を高め、神経再生を誘導し、神経再生治療に有効であり、早期からの運動が社会復帰を早める可能性が示された。

Research Products

• [Journal Article] Pathological Findings in Male Patients With Anti-N-methyl-d-Aspartate Receptor Encephalitis (2019)
  • Author(s): Hirano M1,2, Itoh T3, Fujimura H4, Inoue K4, Samukawa M1,2, Nose K5, Sakamoto H2, Maekura S6, Ueno S1,2, Satou T3, Nishioka T4, Kusunoki S, Nakamura Y
  • Journal Title: J Neuropathol Exp Neurol Volume: - Issue: 8 Pages: 735-741
  • DOI: 10.1093/jnen/nlz052
  • Peer Reviewed / Open Access
• [Journal Article] Pioglitazone inhibits cancer cell growth through STAT3 inhibition and enhanced AIF expression via a PPARγ-independent pathway. (2018)
  • Author(s): Tsubaki M, Takeda T, Tomonari Y, Kawashima K, Itoh T, Imano M, Satou T, Nishida S.
  • Journal Title: J Cell Physiol. Volume: 233 Issue: 4 Pages: 3638-3647
  • DOI: 10.1002/jcp.26225
  • Peer Reviewed / Open Access
• [Journal Article] Rebamipide suppresses 5-fluorouracil-induced cell death via the activation of Akt/mTOR pathway and regulates the expression of Bcl-2 family proteins. (2018)
  • Author(s): Tsubaki M, Takeda T, Asano RT, Matsuda T, Fujimoto SI, Itoh T, Imano M, Satou T, Nishida S.
  • Journal Title: Toxicol In Vitro. Volume: 46 Pages: 284-293
  • DOI: 10.1016/j.tiv.2017.10.019
  • Peer Reviewed / Open Access
• [Presentation] 高齢出産における発達障害発症のリスク因子の解析 (2019)
  • Author(s): 木内葵、村岡歩美、岩崎史、熊野雅洋、末永麻里、蒲尚子、水口信行、佐藤隆夫、伊藤龍生
  • Organizer: 第73回日本栄養・食糧学会大会
• [Presentation] お茶飲料による母体高血糖誘発発達障害発症における改善効果の検討 (2019)
  • Author(s): 熊野雅洋、木内葵、瀬田みなみ、末永麻里、蒲尚子、水口信行、江川賢太郎、佐藤洋、佐藤隆夫、伊藤龍生
  • Organizer: 第73回日本栄養・食糧学会大会
• [Presentation] 高齢出産における妊娠高血圧が及ぼす発達障害の発症機序の解明 (2018)
  • Author(s): 木内葵、蒲尚子、藪口友暉、熊野雅洋、末永麻里、水口信行、江川賢太郎、田渕正樹、佐藤隆夫、伊藤龍生
  • Organizer: 第72回日本栄養・食糧学会大会
• [Presentation] 母胎高血糖由来のラット胎仔神経幹細胞分化異常に対するカテキンの改善効果 (2018)
  • Author(s): 熊野雅洋、木内葵、蒲尚子、水口信行、江川賢太郎、末永麻里、佐藤隆夫、伊藤龍生
  • Organizer: 第72回日本栄養・食糧学会大会
• [Book] 知る！わかる！身につく！！公衆栄養学 第二版 (2020)
  • Author(s): 伊藤龍生他
  • Total Pages: 232
  • Publisher: 同文書院
  • ISBN: 9784810315004