| Project/Area Number |
17K01501
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Rehabilitation science/Welfare engineering
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| Research Institution | Kobe University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
河上 敬介 大分大学, 福祉健康科学部, 教授 (60195047)
田口 徹 新潟医療福祉大学, リハビリテーション学部, 教授 (90464156)
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| Project Period (FY) |
2017-04-01 – 2020-03-31
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| Project Status |
Completed (Fiscal Year 2019)
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| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2019: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2018: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2017: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
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| Keywords | 寒冷療法 / 温熱療法 / マクロファージ / 寒冷刺激 / 温熱刺激 / MCP-1 / 骨格筋 / 寒冷 / 温熱 / 再生 |
|---|
| Outline of Final Research Achievements |
Owing to the icing application for 20min soon after the muscle crush injury, accumulation of the macrophages was inhibited until 12h after injury. Numbers of the neutrophils at 3h after the injury and the MCP-1+ cells at 6h and later after the injury in the icing group were significantly lower than those in the non-icing group, suggesting that these phenomena contribute to the retardation of macrophage migration.
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| Academic Significance and Societal Importance of the Research Achievements |
筋損傷後に常識とされてきた寒冷療法は、筋再生を遅延、抑制させてしまう。そのことのメカニズムが明らかとなってきた。すなわち、筋損傷後に筋再生を促すためには温熱療法が優れていることを示していると考えられる。理学療法、およびスポーツの現場における対処法における常識を考え直す必要がある。
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