| Project/Area Number |
17K01507
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Rehabilitation science/Welfare engineering
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| Research Institution | Nagasaki University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
神津 玲 長崎大学, 医歯薬学総合研究科(保健学科), 教授 (80423622)
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| Project Period (FY) |
2017-04-01 – 2021-03-31
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| Project Status |
Completed (Fiscal Year 2020)
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| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2019: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2018: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2017: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Keywords | 敗血症 / 神経筋電気刺激療法 / 筋萎縮 / 筋委縮 / 電気刺激療法 / リハビリテーション |
|---|
| Outline of Final Research Achievements |
In ICU patients, we were examined that the effectiveness of neuromuscular electrical stimulation for ICU-acquired muscle weakness (ICU-AW) using urinary 3-methylhistidine (3-MH) as muscle proteolytic. 3-MH could be measured in 7 cases, and 3-MH was decreased. However, the conditions of collecting urine were often different Therefore, our results were unreliable and could not be characteristic.
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| Academic Significance and Societal Importance of the Research Achievements |
現在までの先行研究においては，ICUに入室する重症患者におけるNMESの有効性を示す報告がなされているが，神経筋電気刺激療法における蛋白分解の特徴を証明した報告がなく，方法論確立に向けた筋線維の蛋白分解レベルでの推移や特徴を捉える検討は必要不可欠である．また，最適な介入時期の検討に関する報告は散見されず，本研究のような取り組みは重要である．
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