Functional regeneration program for the damaged brain with hemispatial apraxia using the stereoscopic sensory stimulation and transcranial alternating current stimulation.
| Project/Area Number |
17K01527
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Rehabilitation science/Welfare engineering
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| Research Institution | International University of Health and Welfare |
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Principal Investigator |
Goto Yoshinobu 国際医療福祉大学, 医学部, 教授 (30336028)
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| Project Period (FY) |
2017-04-01 – 2023-03-31
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| Project Status |
Completed (Fiscal Year 2022)
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| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2021: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2020: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2019: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2018: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2017: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Keywords | 半側空間失認 / 立体感覚刺激 / 経頭蓋交流刺激 / 誘発電位 / 誘発電位・誘発脳磁界 / 経頭蓋直流刺激 / γ帯域律動波 / 安静時機能的MRI / 脳波周波数解析 / 経頭蓋交流電流刺激 / 経頭蓋直流電流刺激 / 交流電流刺激 / 直流電流刺激 / 機能的MRI |
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| Outline of Final Research Achievements |
To evaluate the 3D-visuo-auditory stimulation to promote the reorganization of the damaged brain with unilateral spatial agnosia (USA). 3D-visuo-auditory movies were presented to the healthy adults and USA patients, aged from 40 to 60 years, for 2 hours a day for 2 weeks. The effects of stimulation were checked by the psychophysical and electromagnetic examinations with visual 3D optic flow stimulation. Transcranial alternating current stimulation (t-ACS) at 10 Hz for 20 min during video presentation was also studied. As a result, the motion recognition threshold was recovered in the healthy and USA groups after this 3D-visuo-auditory training. No significant changes were observed in electrophysiological examinations after t-ACS. Therefore, these results suggest that the sensory stimulation may be able to reorganize the elderly brain function. However, further studies should be needed to decide the optimal parameters for the t-ACS.
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| Academic Significance and Societal Importance of the Research Achievements |
本研究では、健常脳と障害脳(USA脳)での立体感覚(視覚)に伴う脳内情報処理メカニズムの相違を解析したことで、USA脳での脳内情報処理ネットワークの時間的・空間的機能連関の一端を明らかにでき、USA脳での情報処理障害モデルの基礎となる結果を得られた。また、脳波周期活動への作用が考えられるt-ACSの効果を明確にすることができず、t-ACSの最適刺激条件を見つけ出すまでには至らなかった。今後、t-ACSの最適条件の設定ができれば、USAに対する部位特異的効果を長期間発揮するニューロリハビリテーションを提案することも可能となると思われる。
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Report
(7 results)
Research Products
(55 results)
