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Functional regeneration program for the damaged brain with hemispatial apraxia using the stereoscopic sensory stimulation and transcranial alternating current stimulation.

Research Project

Project/Area Number 17K01527
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Rehabilitation science/Welfare engineering
Research InstitutionInternational University of Health and Welfare

Principal Investigator

Goto Yoshinobu  国際医療福祉大学, 医学部, 教授 (30336028)

Project Period (FY) 2017-04-01 – 2023-03-31
Project Status Completed (Fiscal Year 2022)
Budget Amount *help
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2021: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2020: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2019: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2018: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2017: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Keywords半側空間失認 / 立体感覚刺激 / 経頭蓋交流刺激 / 誘発電位 / 誘発電位・誘発脳磁界 / 経頭蓋直流刺激 / γ帯域律動波 / 安静時機能的MRI / 脳波周波数解析 / 経頭蓋交流電流刺激 / 経頭蓋直流電流刺激 / 交流電流刺激 / 直流電流刺激 / 機能的MRI
Outline of Final Research Achievements

To evaluate the 3D-visuo-auditory stimulation to promote the reorganization of the damaged brain with unilateral spatial agnosia (USA). 3D-visuo-auditory movies were presented to the healthy adults and USA patients, aged from 40 to 60 years, for 2 hours a day for 2 weeks. The effects of stimulation were checked by the psychophysical and electromagnetic examinations with visual 3D optic flow stimulation. Transcranial alternating current stimulation (t-ACS) at 10 Hz for 20 min during video presentation was also studied. As a result, the motion recognition threshold was recovered in the healthy and USA groups after this 3D-visuo-auditory training. No significant changes were observed in electrophysiological examinations after t-ACS. Therefore, these results suggest that the sensory stimulation may be able to reorganize the elderly brain function. However, further studies should be needed to decide the optimal parameters for the t-ACS.

Academic Significance and Societal Importance of the Research Achievements

本研究では、健常脳と障害脳(USA脳)での立体感覚(視覚)に伴う脳内情報処理メカニズムの相違を解析したことで、USA脳での脳内情報処理ネットワークの時間的・空間的機能連関の一端を明らかにでき、USA脳での情報処理障害モデルの基礎となる結果を得られた。また、脳波周期活動への作用が考えられるt-ACSの効果を明確にすることができず、t-ACSの最適刺激条件を見つけ出すまでには至らなかった。今後、t-ACSの最適条件の設定ができれば、USAに対する部位特異的効果を長期間発揮するニューロリハビリテーションを提案することも可能となると思われる。

Report

(7 results)
  • 2022 Annual Research Report   Final Research Report ( PDF )
  • 2021 Research-status Report
  • 2020 Research-status Report
  • 2019 Research-status Report
  • 2018 Research-status Report
  • 2017 Research-status Report
  • Research Products

    (55 results)

All 2022 2021 2020 2019 2018 2017

All Journal Article (16 results) (of which Int'l Joint Research: 3 results,  Peer Reviewed: 16 results,  Open Access: 16 results) Presentation (36 results) (of which Int'l Joint Research: 11 results,  Invited: 11 results) Book (3 results)

  • [Journal Article] Weighted Blind Source Separation Can Decompose the Frequency Mismatch Response by Deviant Concatenation: An MEG Study2022

    • Author(s)
      Matsubara Teppei、Stufflebeam Steven、Khan Sheraz、Ahveninen Jyrki、H?m?l?inen Matti、Goto Yoshinobu、Maekawa Toshihiko、Tobimatsu Shozo、Kishida Kuniharu
    • Journal Title

      Frontiers in Neurology

      Volume: 13 Pages: 762497-762497

    • DOI

      10.3389/fneur.2022.762497

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Bilateral Representation of Sensorimotor Responses in Benign Adult Familial Myoclonus Epilepsy: An MEG Study.2021

    • Author(s)
      Matsubara T, Ahlfors S.P, Mima T, Hagiwara K, Shigeto H, Tobimatsu S, Goto Y & Stufebeam S
    • Journal Title

      Frontiers in Neurology

      Volume: 12 Pages: 759866-759866

    • DOI

      10.3389/fneur.2021.759866

    • Related Report
      2021 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] After-Effects of Intermittent Theta-Burst Stimulation Are Differentially and Phase-Dependently Suppressed by α- and β-Frequency Transcranial Alternating Current Stimulation2021

    • Author(s)
      Ogata K, Nakazono H, Ikeda T, Oka S, Goto Y, Tobimatsu S.
    • Journal Title

      Frontiers in human neuroscience

      Volume: 15 Pages: 750329-750329

    • DOI

      10.3389/fnhum.2021.750329

    • Related Report
      2021 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Influence of a dual task with finger movement frequency controland different levels of divided attention on motor-related corticalpotential.2020

    • Author(s)
      Hirano D, Goto Y, Jinnai D, Taniguchi T
    • Journal Title

      J Physical Ther Sci

      Volume: 32 Pages: 710-716

    • Related Report
      2020 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] 非利き手運動中のγ帯域律動反応の変化.2020

    • Author(s)
      溝口貴之、池田拓郎、高嶋美和、後藤和彦、岡真一郎、後藤純信
    • Journal Title

      理学療法科学

      Volume: 35 Pages: 527-531

    • NAID

      130007889049

    • Related Report
      2020 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] The effect of stimulus pattern, color combination and flicker frequency on steady-state visual evoked potentials topography.2019

    • Author(s)
      Kazuhiko Goto, Takenao Sugi ,Hiroki Fukuda,Takao Yamasaki,Shozo Tobimatsu, Yoshinobu Goto.
    • Journal Title

      International Journal of Innovative Computing, Information and Control

      Volume: 15 Pages: 1521-1530

    • Related Report
      2019 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] 閃光刺激による定常状態型視覚誘発電位の定量解析:刺激頻度変化による反応特性の検討.2019

    • Author(s)
      池田拓郎,後藤和彦,岡真一郎,杉剛直,福田裕樹,後藤純信
    • Journal Title

      理学療法科学

      Volume: 34 Pages: 41-45

    • NAID

      130007604497

    • Related Report
      2019 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] バーチャルリアリティ環境におけるニューロリハビリテーションの可能性.2019

    • Author(s)
      岡 真一郎, 池田 拓郎, 吉田 誠也, 近藤 遥奈, 筒井 友美, 田中 晴菜, 後藤 和彦, 光武 翼, 後藤 純信
    • Journal Title

      神経眼科

      Volume: 36 Pages: 36-43

    • NAID

      130007636244

    • Related Report
      2019 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] 健常人の錯視生起に影響する視覚要素~心理物理学的検討~.2019

    • Author(s)
      伊藤香織、原直人、後藤純信
    • Journal Title

      神経眼科

      Volume: 36 Pages: 44-53

    • NAID

      130007636245

    • Related Report
      2019 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] 運動知覚への両眼視差刺激の影響:視覚誘発電位を用いた検討.2019

    • Author(s)
      後藤和彦、杉 剛直、池田拓郎、山崎貴男、飛松省三、後藤純信
    • Journal Title

      臨床神経生理学

      Volume: 47 Pages: 509-518

    • NAID

      130007756713

    • Related Report
      2019 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] 視覚誘発電位実時間評価システムを含んだ記録環境の構築2019

    • Author(s)
      山口峻,後藤和彦,杉剛直,松田吉隆,後藤聡,池田拓郎,山崎貴男,飛松省三,後藤純信
    • Journal Title

      信学技報

      Volume: 118 Pages: 13-16

    • Related Report
      2019 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Quantitative Analysis of Steady-state Visual Evoked Potentials Using Flash Stimulations: Response Characteristics of Different Frequency Stimuli2019

    • Author(s)
      池田拓郎、後藤和彦、岡真一郎、杉剛直、福田裕樹、 後藤純信
    • Journal Title

      Rigakuryoho Kagaku

      Volume: 34 Issue: 1 Pages: 41-45

    • DOI

      10.1589/rika.34.41

    • NAID

      130007604497

    • ISSN
      1341-1667, 2434-2807
    • Related Report
      2018 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Effects of Transcranial Direct Current Stimulation to the Right Parietal Cortex on Standing Postural Control2018

    • Author(s)
      岡 真一郎,池田 拓郎,後藤 和彦,近藤 遥奈,吉田 誠,光武 翼,後藤 純信
    • Journal Title

      Rigakuryoho Kagaku

      Volume: 33 Issue: 2 Pages: 357-360

    • DOI

      10.1589/rika.33.357

    • NAID

      130006727819

    • ISSN
      1341-1667, 2434-2807
    • Related Report
      2018 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] 右頭頂葉に対する経頭蓋直流電流刺激が立位姿勢調節に及ぼす影響2018

    • Author(s)
      岡真一郎,池田拓郎,後藤和彦,近藤遥奈,吉田誠,光武翼,後藤純信
    • Journal Title

      理学療法科学

      Volume: 33 Pages: 357-360

    • NAID

      130006727819

    • Related Report
      2017 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Auditory hemispheric specialization depends on temporal and spectral frequencies.2017

    • Author(s)
      Goto Y, Yamasaki T, Tobimatsu S
    • Journal Title

      BAOJ Psychology

      Volume: 2 Pages: 1-9

    • Related Report
      2017 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] The effects of divided attention on visual evoked magnetic fields during mental arithmetic tasks and a verbal fluency task2017

    • Author(s)
      池田拓郎、水野健太郎、後藤和彦、後藤純信
    • Journal Title

      Japanese Journal of Clinical Neurophysiology

      Volume: 45 Issue: 3 Pages: 137-145

    • DOI

      10.11422/jscn.45.137

    • NAID

      130006398077

    • ISSN
      1345-7101, 2188-031X
    • Related Report
      2017 Research-status Report
    • Peer Reviewed / Open Access
  • [Presentation] 頭頂部に対する経頭蓋交流電流刺激がトレッドミル歩行後の身体動揺に与える影響2022

    • Author(s)
      岡真一郎、池田拓郎、後藤純信
    • Organizer
      第52回日本臨床神経生理学会学術大会
    • Related Report
      2022 Annual Research Report
  • [Presentation] 視差勾配の違いが自己運動知覚に与える影響:sLORETA による視覚誘発電位の信号源推定2022

    • Author(s)
      後藤和彦、杉剛直、池田拓郎、後藤純信
    • Organizer
      第52回日本臨床神経生理学会学術大会
    • Related Report
      2022 Annual Research Report
  • [Presentation] Optic flow 感覚閾値が歩行時の頭部動揺に与える影響2022

    • Author(s)
      池田拓郎、後藤純信
    • Organizer
      第52回日本臨床神経生理学会学術大会
    • Related Report
      2022 Annual Research Report
  • [Presentation] 脳機能障害の基礎2021

    • Author(s)
      後藤純信
    • Organizer
      第17回日本子ども学会学術集会
    • Related Report
      2021 Research-status Report
    • Invited
  • [Presentation] Prefrontal cortical activation while actual driving to stopping: a functional near-infrared spectroscopy study2021

    • Author(s)
      平野大輔、後藤純信
    • Organizer
      7th Asian-Oceanian Congress on Clinical Neurophysiology
    • Related Report
      2021 Research-status Report
    • Int'l Joint Research
  • [Presentation] 運動視刺激による視覚性事象関連電位の変化:刺激速度による検討2021

    • Author(s)
      池田拓郎、後藤純信
    • Organizer
      第51回日本臨床神経生理学会学術大会
    • Related Report
      2021 Research-status Report
  • [Presentation] Differential effects of 20 and 10 Hz-tACS on MEPs with intermittent Theta Burst Stimulation2020

    • Author(s)
      Goto Y
    • Organizer
      The 14th ICME International Conference on Complex Medical Engineering(CME 2020)
    • Related Report
      2020 Research-status Report
    • Int'l Joint Research / Invited
  • [Presentation] ベーシックレクチャー:VEP(視覚誘発電位)2020

    • Author(s)
      後藤純信
    • Organizer
      第50回日本臨床神経生理学会学術大会
    • Related Report
      2020 Research-status Report
    • Invited
  • [Presentation] Roles of intrinsic and extrinsic neural oscillations in the brain.2019

    • Author(s)
      Yoshinobu Goto
    • Organizer
      The 13th ICME International Conference on Complex Medical Engineering(CME 2019)
    • Related Report
      2019 Research-status Report
    • Int'l Joint Research / Invited
  • [Presentation] Visual evoked magnetic fields to 8Hz repetitive pattern-reversal stimulation.2019

    • Author(s)
      Yoshinobu Goto
    • Organizer
      Neuroscience meeting 2019
    • Related Report
      2019 Research-status Report
    • Int'l Joint Research
  • [Presentation] 視覚誘発電位(新ガイドライン)2019

    • Author(s)
      後藤純信
    • Organizer
      第49回日本臨床神経生理学会学術大会
    • Related Report
      2019 Research-status Report
    • Invited
  • [Presentation] 明日から役立つ視覚誘発電位のピットホール2019

    • Author(s)
      後藤純信
    • Organizer
      第49回日本臨床神経生理学会学術大会
    • Related Report
      2019 Research-status Report
    • Invited
  • [Presentation] ランダムドットステレオグラムに対する視覚誘発電位の解析:視差勾配の影響2019

    • Author(s)
      後藤和彦、杉 剛直、池田拓郎、山崎貴男、飛松省三、後藤純信
    • Organizer
      第49回日本臨床神経生理学会学術大会
    • Related Report
      2019 Research-status Report
  • [Presentation] ベーシックレクチャー21:VEP2018

    • Author(s)
      後藤純信
    • Organizer
      第48回日本臨床神経生理学会学術大会
    • Related Report
      2018 Research-status Report
    • Invited
  • [Presentation] Cutting-edge technologies for clinical neuroscience2018

    • Author(s)
      Yoshinobu Goto
    • Organizer
      The 12th ICME International Conference on Complex Medical Engineering(CME 2018)
    • Related Report
      2018 Research-status Report
    • Int'l Joint Research / Invited
  • [Presentation] Spatiotemporal changes in steady-state visual evoked potentials during the mental arithmetic2018

    • Author(s)
      Ikeda T, Goto K, Oka S,Sugi T, Goto Y
    • Organizer
      The 12th ICME International Conference on Complex Medical Engineering(CME 2018)
    • Related Report
      2018 Research-status Report
    • Int'l Joint Research
  • [Presentation] Neural mechanism of optokinetic eye movement in visual stimuli.(Symposium)2018

    • Author(s)
      Oka S, Sugi T, Ikeda T, Goto Y
    • Organizer
      The 12th ICME International Conference on Complex Medical Engineering(CME 2018)
    • Related Report
      2018 Research-status Report
    • Int'l Joint Research
  • [Presentation] 奥行運動刺激時の視覚誘発電位における運動知覚と奥行き知覚の相互作用2018

    • Author(s)
      後藤和彦、杉剛直、池田拓郎、山崎貴男、飛松省三、後藤純信
    • Organizer
      第48回日本臨床神経生理学会学術大会
    • Related Report
      2018 Research-status Report
  • [Presentation] 手指運動中のγ帯域律動反応の変化2018

    • Author(s)
      溝口貴之、池田拓郎、後藤和彦、岡真一郎、高嶋美和、後藤純信
    • Organizer
      第48回日本臨床神経生理学会学術大会
    • Related Report
      2018 Research-status Report
  • [Presentation] 左半側空間無視の機能的結合性の変化~安静時fMRIによる検討~2018

    • Author(s)
      甲斐慎介、上原平福山幸三、原田啓、後藤純信
    • Organizer
      第42回日本高次脳障害学会学術総会
    • Related Report
      2018 Research-status Report
  • [Presentation] 後頭葉病変における病巣部位による症状の傾向2018

    • Author(s)
      伊藤香織、後藤純信
    • Organizer
      第42回日本高次脳障害学会学術総会
    • Related Report
      2018 Research-status Report
  • [Presentation] 道具使用時の前頭葉活動:近赤外分光法(NIRS)を用いた検討2018

    • Author(s)
      原麻里子、後藤純信、前田眞治、菅原光晴、山本潤
    • Organizer
      第42回日本高次脳障害学会学術総会
    • Related Report
      2018 Research-status Report
  • [Presentation] Visualization of brain2017

    • Author(s)
      Goto Y
    • Organizer
      5th Meeting of Physical Therapy Science in Beijing
    • Related Report
      2017 Research-status Report
    • Int'l Joint Research / Invited
  • [Presentation] 後頭葉病変の障害部位による臨床症状の相違2017

    • Author(s)
      伊藤香織、後藤純信
    • Organizer
      第22回日本認知神経科学会学術大会
    • Related Report
      2017 Research-status Report
  • [Presentation] Long-term course of a patient with cognitive impairment in childhood.2017

    • Author(s)
      Iwasaki Y、Goto Y、Takashima S
    • Organizer
      APCSLH2017;Asia Pacific Conference on Speech, Language, and Hearing
    • Related Report
      2017 Research-status Report
    • Int'l Joint Research
  • [Presentation] 障害脳を探る2017

    • Author(s)
      後藤純信
    • Organizer
      リハビリテーション・ケア合同研究大会久留米2017
    • Related Report
      2017 Research-status Report
    • Invited
  • [Presentation] 錯視生起に関する視覚要素の脳内情報処理.2017

    • Author(s)
      伊藤香織、後藤純信、原直人、小山智生
    • Organizer
      第55回日本神経眼科学会総会
    • Related Report
      2017 Research-status Report
  • [Presentation] Difference of visual evoked magnetic fields with mental arithmetic tasks and2017

    • Author(s)
      Goto Y
    • Organizer
      2017 Neuroscience meeting
    • Related Report
      2017 Research-status Report
    • Int'l Joint Research
  • [Presentation] Verification of the reciprocal inhibition between visual and vestibular system using a t-DCS.2017

    • Author(s)
      Oka S, Ikeda T, Goto Y
    • Organizer
      The 11th ICME International Conference on Complex Medical Engineering(CME 2017)
    • Related Report
      2017 Research-status Report
    • Int'l Joint Research
  • [Presentation] VEP: 基礎と臨床2017

    • Author(s)
      後藤純信
    • Organizer
      第47回日本臨床神経生理学会学術大会
    • Related Report
      2017 Research-status Report
    • Invited
  • [Presentation] 一側頭頂葉に対する経頭蓋直流電流刺激が平衡機能に及ぼす影響.2017

    • Author(s)
      岡真一郎、池田拓郎、後藤和彦、近藤遥奈、吉田誠也、島雄南、上原嵯季、柴田良真、後藤純信
    • Organizer
      第47回日本臨床神経生理学会学術大会
    • Related Report
      2017 Research-status Report
  • [Presentation] 奥行運動刺激に対する視覚誘発電位の特徴解析.2017

    • Author(s)
      後藤和彦、杉剛直、池田拓郎、山崎貴男、飛松省三、後藤純信
    • Organizer
      第47回日本臨床神経生理学会学術大会
    • Related Report
      2017 Research-status Report
  • [Presentation] 色組み合わせに関する上下半視野パターン反転刺激時の視覚誘発電位特徴解析.2017

    • Author(s)
      大庭尚之、後藤和彦、杉剛直、松田吉隆、後藤聡、池田拓郎、山崎貴男、飛松省三、後藤純信
    • Organizer
      第47回日本臨床神経生理学会学術大会
    • Related Report
      2017 Research-status Report
  • [Presentation] 暗算負荷による定常視覚誘発電位の変化-刺激頻度4Hzと8Hzによる検討-2017

    • Author(s)
      池田拓郎、後藤和彦、岡真一郎、大庭尚之、杉剛直、後藤純信
    • Organizer
      第47回日本臨床神経生理学会学術大会
    • Related Report
      2017 Research-status Report
  • [Presentation] 後頭葉病変の障害部位と神経心理学的検査との相関性の検証.2017

    • Author(s)
      伊藤香織、後藤純信
    • Organizer
      第41回日本高次脳障害学会学術総会
    • Related Report
      2017 Research-status Report
  • [Presentation] 脳障害に対する安静時fMRIの有用性の検討-O-157脳症による検討-2017

    • Author(s)
      甲斐慎介、池田 拓郎, 岡 真一郎, 原 麻理子, 後藤純信
    • Organizer
      第41回日本高次脳障害学会学術総会
    • Related Report
      2017 Research-status Report
  • [Book] 誘発電位測定マニュアル2019. 1. 視覚誘発電位2020

    • Author(s)
      後藤純信、佐々木一朗、佐々木達也、飛松省三、安原昭博、山崎貴男
    • Total Pages
      210
    • Publisher
      診断と治療社
    • Related Report
      2020 Research-status Report
  • [Book] 誘発電位測定マニュアル20192019

    • Author(s)
      後藤純信、佐々木一朗、佐々木達也、飛松省三、安原昭博、山崎貴男
    • Total Pages
      110
    • Publisher
      診断と治療社
    • ISBN
      9784787824462
    • Related Report
      2019 Research-status Report
  • [Book] 解きながら身につく臨床神経生理学のポイント.日本臨床神経生理学会専門医・専門技師 試験問題・解説 120.2018

    • Author(s)
      後藤純信 (分担執筆)
    • Total Pages
      2
    • Publisher
      診断と治療社
    • Related Report
      2018 Research-status Report

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Published: 2017-04-28   Modified: 2024-01-30  

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