Development of a physiotherapy algorithm for musculoskeletal pain based on assessment of central sensitization

• Project/Area Number: 17K01543
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Rehabilitation science/Welfare engineering
• Research Institution: Prefectural University of Hiroshima (2019-2021); Konan Women's University (2017-2018)
• Principal Investigator: Nishigami Tomohiko 県立広島大学, 保健福祉学部(三原キャンパス), 教授 (60515691)
• Project Period (FY): 2017-04-01 – 2022-03-31
• Project Status: Completed (Fiscal Year 2021)
• Budget Amount: ¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000); Fiscal Year 2019: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000); Fiscal Year 2018: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000); Fiscal Year 2017: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
• Keywords: 疼痛 / 中枢性感作 / 理学療法 / 能力障害 / 中枢性感作症候群 / 疼痛神経科学教育 / 乳がん / 筋骨格系障害疼痛 / 慢性痛 / アルゴリズム / 教育 / 筋骨格系疼痛

Outline of Final Research Achievements

We examined whether the severity level of central sensitization syndrome prior to the start of physical therapy could predict pain and disability after 3 months of physical therapy. 150 patients with musculoskeletal disorders were evaluated before and after the start of physical therapy for CSI, an assessment of central sensitization syndrome; EQ5D, an assessment of quality of life; and BPI, an assessment of pain and disability. 3 months later, patients with moderate to high baseline CSI severity had lower baseline CSI severity and The rate was significantly higher (p<0.001) than that of patients with On the other hand, pain was not predicted by CSI. The results of this study led to the development of a physiotherapy algorithm based on CSI.

Academic Significance and Societal Importance of the Research Achievements

中枢性感作は治療反応性に深く関与することが示唆されながら，理学療法の治療効果に影響するか明らかではなかった．本研究結果によって，中枢性感作の理学療法の治療効果への寄与が明らかになった．具体的には，CSI質問表で理学療法開始前に30点以上の場合は能力障害が改善しない可能性が高いことから，教育や有酸素運動などを行う必要性が有り，医学的，社会的意義は高い．

Research Products

• [Journal Article] Effect of perioperative pain neuroscience education in patients with post-mastectomy persistent pain: a retrospective, propensity score-matched study. (2021)
  • Author(s): Manfuku M, Nishigami T, Mibu A, Yamashita H, Imai R, Tanaka K, Kitagaki K, Hiroe K, Sumiyoshi K.
  • Journal Title: Support Care Cancer Volume: 29 Issue: 9 Pages: 5351-5359
  • DOI: 10.1007/s00520-021-06103-1
  • Peer Reviewed
• [Journal Article] Establishing Central Sensitization-Related Symptom Severity Subgroups: A Multicountry Study Using the Central Sensitization Inventory (2020)
  • Author(s): Cuesta-Vargas AI, Neblett R, Nijs J, Chiarotto A, Kregel J, van Wilgen CP, Pitance L, Knezevic A, Gatchel RJ, Mayer TG, Viti C, Roldan-Jimnez C, Testa M, Caumo W, Jeremic-Knezevic M, Nishigami T, Feliu-Soler A, Luciano JV.
  • Journal Title: Pain Medicine Volume: 21 Issue: 6 Pages: 2430-2440
  • DOI: 10.1111/papr.13005
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Embodying the illusion of a strong, fit back in people with chronic low back pain. A pilot proof-of-concept study. (2019)
  • Author(s): Nishigami T, Wand BM, Newport R, Ratcliffe N, Themelis K, Moen D, Jones C, Moseley GM, Stanton TR.
  • Journal Title: Musculoskeletal science & practice. Volume: 39 Pages: 178-183
  • DOI: 10.1016/j.msksp.2018.07.002
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Validation of the Japanese Version of the Fremantle Back Awareness Questionnaire in Patients with Low Back Pain. (2018)
  • Author(s): Nishigami T, Mibu A, Tanaka K, Yamashita Y, Shimizu ME, Wand BM, Catley MJ, Stanton TR, Moseley GL.
  • Journal Title: Pain Practice Volume: 18 Issue: 2 Pages: 170-179
  • DOI: 10.1111/papr.12586
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Differences in Risk Factors for Rotator Cuff Tears between Elderly Patients and Young Patients (2018)
  • Author(s): Watanabe A, Ono Q, Nishigami T, Hirooka T, Machida H.
  • Journal Title: Acta Medica Okayama Volume: 72 Issue: 1 Pages: 67-72
  • DOI: 10.18926/AMO/55665
  • NAID: 120006398865
  • URL: https://ousar.lib.okayama-u.ac.jp/55665
  • Peer Reviewed
• [Journal Article] Association between the Critical Shoulder Angle and Rotator Cuff Tears in Japan (2018)
  • Author(s): Watanabe A, Ono Q, Nishigami T, Hirooka T, Machida H.
  • Journal Title: Acta Medica Okayama Volume: 72 Issue: 6 Pages: 547-551
  • DOI: 10.18926/AMO/56371
  • NAID: 120006545156
  • URL: https://ousar.lib.okayama-u.ac.jp/56371
  • Peer Reviewed
• [Journal Article] Development and psychometric properties of short form of central sensitization inventory in participants with musculoskeletal pain: A cross-sectional study (2018)
  • Author(s): Nishigami T, Tanaka K, Mibu A, Manfuku M, Yono S, Tanabe A.
  • Journal Title: Plos One Volume: 13 Issue: 7 Pages: e0200152-e0200152
  • DOI: 10.1371/journal.pone.0200152
  • Peer Reviewed / Open Access
• [Journal Article] Validation of the Japanese version of the Central Sensitization Inventory in patients with musculoskeletal disorders (2017)
  • Author(s): Katsuyoshi Tanaka, Tomohiko Nishigami, Akira Mibu, Masahiro Manfuku, Satoko Yono, Yoshikazu Shinohara, Akihito Tanabe, Rei Ono
  • Journal Title: PLOS ONE Volume: 12 Issue: 12 Pages: e0188719-e0188719
  • DOI: 10.1371/journal.pone.0188719
  • NAID: 120006377641
  • Peer Reviewed / Open Access