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Effects of split-belt gait training for gait asymmetry in Parkinson's disease

Research Project

Project/Area Number 17K01545
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Rehabilitation science/Welfare engineering
Research InstitutionKio University

Principal Investigator

Okada Yohei  畿央大学, 健康科学部, 准教授 (80511568)

Project Period (FY) 2017-04-01 – 2022-03-31
Project Status Completed (Fiscal Year 2021)
Budget Amount *help
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2020: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2019: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2018: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2017: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Keywordsパーキンソン病 / 歩行 / 理学療法 / リハビリテーション / 分離トレドミル / 運動療法 / 歩行障害 / 対称性 / split-belt treadmill / 適応 / すくみ足 / 分離トレッドミル / 左右非対称性 / 左右対称性
Outline of Final Research Achievements

Study 1 elucidated that the increased risk of forward loss of equilibrium is associated with decreased step length, while forward dynamic instability is associated with increased cadence in Parkinson's disease(PD) patients with freezing of gait(FOG). Study 2 revealed that PD patients tend to turn close to the TUG marker, and this turning strategy may be associated with the decreased step length when turning. Study 3 found that the novel split-belt gait training, in which left and right belt speeds are varied in a pendulum fashion, may improve gait asymmetry in PD patients with FOG. Study 4 provided the first evidence on the favorable effects of long-term physiotherapy on motor symptoms in off period and the antiparkinsonian medication dosage.

Academic Significance and Societal Importance of the Research Achievements

研究1と2によりパーキンソン病(PD)患者の歩行不安定性の関連要因や方向転換の異常に関連する要因についての新たな知見が得られ,これらは今後の歩行障害に対するリハビリテーションの発展に寄与するものである。研究3による知見は,PD患者のすくみ足と関連する重要な問題である歩行左右非対称性に対する新たなリハビリテーション介入の手段として分離トレッドミルを用いた歩行練習が有用であることを示唆するものである。研究4による成果は,長期間の理学療法が薬効状態が不良な時の運動症状を改善し,抗PD薬内服量を減少することに関するエビデンスを初めて示すものであり,PD患者や医療従事者にとって大変重要な情報を提供した。

Report

(6 results)
  • 2021 Annual Research Report   Final Research Report ( PDF )
  • 2020 Research-status Report
  • 2019 Research-status Report
  • 2018 Research-status Report
  • 2017 Research-status Report
  • Research Products

    (42 results)

All 2022 2021 2020 2019 2018 2017 Other

All Journal Article (22 results) (of which Int'l Joint Research: 4 results,  Peer Reviewed: 15 results,  Open Access: 6 results) Presentation (16 results) (of which Invited: 11 results) Book (3 results) Remarks (1 results)

  • [Journal Article] Effect of galvanic vestibular stimulation on axial symptoms in Parkinson’s disease2022

    • Author(s)
      Kataoka Hiroshi、Okada Yohei、Kiriyama Takao、Kita Yorihiro、Nakamura Junji、Shomoto Koji、Sugie Kazuma
    • Journal Title

      Journal of Central Nervous System Disease

      Volume: 14 Pages: 1-5

    • DOI

      10.1177/11795735221081599

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Effectiveness of Long-Term Physiotherapy in Parkinson’s Disease: A Systematic Review and Meta-Analysis2021

    • Author(s)
      Okada Yohei、Ohtsuka Hiroyuki、Kamata Noriyuki、Yamamoto Satoshi、Sawada Makoto、Nakamura Junji、Okamoto Masayuki、Narita Masaru、Nikaido Yasutaka、Urakami Hideyuki、Kawasaki Tsubasa、Morioka Shu、Shomoto Koji、Hattori Nobutaka
    • Journal Title

      Journal of Parkinson's Disease

      Volume: 11 Issue: 4 Pages: 1619-1630

    • DOI

      10.3233/jpd-212782

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Dynamic stability during gait in idiopathic normal pressure hydrocephalus and Parkinson's disease2021

    • Author(s)
      Nikaido Yasutaka、Okada Yohei、Urakami Hideyuki、Ishida Naoya、Akisue Toshihiro、Kawami Yuki、Kuroda Kenji、Kajimoto Yoshinaga、Saura Ryuichi
    • Journal Title

      Acta Neurologica Scandinavica

      Volume: 145 Issue: 2 Pages: 215-222

    • DOI

      10.1111/ane.13537

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Forward gait instability in patients with Parkinson’s disease with freezing of gait2021

    • Author(s)
      Urakami Hideyuki、Nikaido Yasutaka、Kuroda Kenji、Ohno Hiroshi、Saura Ryuichi、Okada Yohei
    • Journal Title

      Neuroscience Research

      Volume: 173 Pages: 80-89

    • DOI

      10.1016/j.neures.2021.06.007

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Footsteps and walking trajectories during the Timed Up and Go test in young, older, and Parkinson’s disease subjects2021

    • Author(s)
      Okada Yohei、Yorozu Ayanori、Fukumoto Takahiko、Morioka Shu、Shomoto Koji、Aoyama Tomoki、Takahashi Masaki
    • Journal Title

      Gait & Posture

      Volume: 89 Pages: 54-60

    • DOI

      10.1016/j.gaitpost.2021.06.021

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Reliability and laterality of the soleus H-reflex following galvanic vestibular stimulation in healthy individuals2021

    • Author(s)
      Nakamura Junji、Okada Yohei、Shiozaki Tomoyuki、Tanaka Hiroaki、Ueta Kozo、Ikuno Koki、Morioka Shu、Shomoto Koji
    • Journal Title

      Neuroscience Letters

      Volume: 755 Pages: 135910-135910

    • DOI

      10.1016/j.neulet.2021.135910

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] パーキンソン病の理学療法の現状と今後の展望2021

    • Author(s)
      岡田洋平
    • Journal Title

      難病と在宅ケア

      Volume: 27 Pages: 24-27

    • Related Report
      2021 Annual Research Report
  • [Journal Article] Perceived and actual changes in gait balance after CSF shunting in idiopathic normal pressure hydrocephalus2021

    • Author(s)
      Nikaido Yasutaka、Urakami Hideyuki、Akisue Toshihiro、Okada Yohei、Kawami Yuki、Ishida Naoya、Kuroda Kenji、Ohno Hiroshi、Kajimoto Yoshinaga、Saura Ryuichi
    • Journal Title

      Acta Neurologica Scandinavica

      Volume: - Issue: 1 Pages: 21-28

    • DOI

      10.1111/ane.13421

    • Related Report
      2020 Research-status Report
    • Peer Reviewed
  • [Journal Article] Posture influences on vestibulospinal tract excitability2021

    • Author(s)
      Tanaka Hiroaki、Nakamura Junji、Siozaki Tomoyuki、Ueta Kozo、Morioka Shu、Shomoto Koji、Okada Yohei
    • Journal Title

      Experimental Brain Research

      Volume: 239 Issue: 3 Pages: 997-1007

    • DOI

      10.1007/s00221-021-06033-8

    • Related Report
      2020 Research-status Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] No Impact of Stochastic Galvanic Vestibular Stimulation on Arterial Pressure and Heart Rate Variability in the Elderly Population2021

    • Author(s)
      Matsugi Akiyoshi、Nagino Koji、Shiozaki Tomoyuki、Okada Yohei、Mori Nobuhiko、Nakamura Junji、Douchi Shinya、Oku Kosuke、Nagano Kiyoshi、Tamaru Yoshiki
    • Journal Title

      Frontiers in Human Neuroscience

      Volume: 15 Pages: 646127-646127

    • DOI

      10.3389/fnhum.2021.646127

    • Related Report
      2020 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] 特集 歩行PART 1 脳神経疾患と歩行 パーキンソン病による歩行障害の評価と治療2020

    • Author(s)
      岡田 洋平
    • Journal Title

      理学療法ジャーナル

      Volume: 54 Issue: 11 Pages: 1285-1290

    • DOI

      10.11477/mf.1551202104

    • ISSN
      0915-0552, 1882-1359
    • Year and Date
      2020-11-15
    • Related Report
      2020 Research-status Report
  • [Journal Article] Possibility of Rehabilitation Developed by Cooperation with Engineering Research2019

    • Author(s)
      岡田 洋平
    • Journal Title

      SYSTEMS, CONTROL AND INFORMATION

      Volume: 63 Issue: 8 Pages: 335-340

    • DOI

      10.11509/isciesci.63.8_335

    • NAID

      130007798463

    • ISSN
      0916-1600, 2424-1806
    • Year and Date
      2019-08-15
    • Related Report
      2019 Research-status Report
    • Open Access
  • [Journal Article] 特集 パーキンソン病up-to-date パーキンソン病のリハビリテーションup-to-date2019

    • Author(s)
      岡田 洋平
    • Journal Title

      作業療法ジャーナル

      Volume: 53 Issue: 9 Pages: 955-959

    • DOI

      10.11477/mf.5001201827

    • ISSN
      0915-1354
    • Year and Date
      2019-08-15
    • Related Report
      2019 Research-status Report
  • [Journal Article] 報告 Wallenberg症候群後のlateropulsionに対する運動療法とgalvanic vestibular stimulationの併用治療の効果-単一事例研究2019

    • Author(s)
      久保洋平, 植田耕造, 植田耕造, 岡田洋平, 森岡周.
    • Journal Title

      理学療法ジャーナル

      Volume: 53 Issue: 6 Pages: 633-639

    • DOI

      10.11477/mf.1551201584

    • ISSN
      0915-0552, 1882-1359
    • Year and Date
      2019-06-15
    • Related Report
      2019 Research-status Report
  • [Journal Article] Associations among falls, gait variability, and balance function in idiopathic normal pressure hydrocephalus2019

    • Author(s)
      Nikaido Y, Urakami H, Akisue T, Okada Y, Katsuta N, Kawami Y, Ikeji T, Kuroda K, Hinoshita T, Ohno H, Kajimoto Y, Saura R
    • Journal Title

      Clin Neurol Neurosurg

      Volume: 183 Pages: 105385-105385

    • DOI

      10.1016/j.clineuro.2019.105385

    • Related Report
      2019 Research-status Report
    • Peer Reviewed
  • [Journal Article] Role of somatosensory and/or vestibular sensory information in subjective postural vertical in healthy adults2019

    • Author(s)
      Nakamura J, Shiozaki T, Tsujimoto N, Ikuno K, Okada Y, Shomoto K
    • Journal Title

      Neurosci Lett

      Volume: 714 Pages: 134598-134598

    • DOI

      10.1016/j.neulet.2019.134598

    • Related Report
      2019 Research-status Report
    • Peer Reviewed
  • [Journal Article] Cerebellar Transcranial Magnetic Stimulation Reduces the Silent Period on Hand Muscle Electromyography During Force Control.2019

    • Author(s)
      Matsugi A, Douchi S, Suzuki K, Oku K, Mori N, Tanaka H, Nishishita S, Bando K, Kikuchi Y, Okada Y
    • Journal Title

      Brain Sci

      Volume: 10 Issue: 2 Pages: 63-63

    • DOI

      10.3390/brainsci10020063

    • Related Report
      2019 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Cerebellum-mediated trainability of eye and head movements for dynamic gazing2019

    • Author(s)
      Matsugi A, Yoshida N, Nishishita S, Okada Y, Mori N, Oku K, Douchi S, Hosomi K, Saitoh Y
    • Journal Title

      PLoS One

      Volume: 14 Issue: 11 Pages: e0224458-e0224458

    • DOI

      10.1371/journal.pone.0224458

    • Related Report
      2019 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] The muscle pre-activity timing of the hamstrings and quadriceps during 180° and 360° rotational jump landings in healthy female subjects.2019

    • Author(s)
      Bai D, Okada Y, Fukumoto T, Ogawa M, Tanaka Y
    • Journal Title

      Asia Pac J Sports Med Arthrosc Rehabil Technol

      Volume: 17 Pages: 16-20

    • DOI

      10.1016/j.asmart.2019.01.001

    • Related Report
      2019 Research-status Report
    • Peer Reviewed
  • [Journal Article] パーキンソン病の歩行障害に対するリハビリテーションの効果と介入戦略2018

    • Author(s)
      岡田洋平
    • Journal Title

      Bio Clinica

      Volume: 33 Pages: 49-52

    • Related Report
      2018 Research-status Report
  • [Journal Article] 特集リハビリテーションとグループ療法2018

    • Author(s)
      岡本昌幸,岡田洋平
    • Journal Title

      総合リハビリテーション

      Volume: 46 Pages: 815-819

    • Related Report
      2018 Research-status Report
  • [Journal Article] パーキンソン病の歩行障害に対するリハビリテーションーUp to date-2018

    • Author(s)
      岡田洋平,萬礼応,福本貴彦,青山朋樹,高橋正樹
    • Journal Title

      Medical Science Digest

      Volume: 44 Pages: 60-63

    • Related Report
      2017 Research-status Report
    • Peer Reviewed
  • [Presentation] パーキンソン病におけるすくみ足に対するリハビリテーション2021

    • Author(s)
      岡田洋平
    • Organizer
      第15回北九州パーキンソン病 リハビリテーション研究会
    • Related Report
      2021 Annual Research Report
    • Invited
  • [Presentation] PD遠隔リハビリのアウトカム2021

    • Author(s)
      岡田洋平
    • Organizer
      第1回パーキンソン病に対する遠隔リハビリテーション研究会
    • Related Report
      2021 Annual Research Report
    • Invited
  • [Presentation] パーキンソン病の理学療法のこれから~コロナ禍の先に~2021

    • Author(s)
      岡田洋平
    • Organizer
      Small Web Conference-Young PD Experts in Northern Japan-
    • Related Report
      2021 Annual Research Report
    • Invited
  • [Presentation] 歩行を実現する神経メカニズム2021

    • Author(s)
      岡田洋平
    • Organizer
      第19回日本神経理学療法学会学術大会
    • Related Report
      2021 Annual Research Report
    • Invited
  • [Presentation] パーキンソン病の運動症状およびレボドパ換算量に対する長期理学療法の効果~メタアナリシス~2021

    • Author(s)
      岡田洋平
    • Organizer
      第15回パーキンソン病・運動障害疾患コングレス
    • Related Report
      2021 Annual Research Report
  • [Presentation] Camptocormia を呈するパーキンソン病患者 2 症例の歩行時の前方不安定性 ~三次元動作解析装置を用いた検証~2021

    • Author(s)
      浦上 英之,二階堂 泰隆,岡田 洋平,佐浦 隆一
    • Organizer
      第19回日本神経理学療法学会学術大会
    • Related Report
      2021 Annual Research Report
  • [Presentation] パーキンソン病に対する理学療法介入とその可能性2020

    • Author(s)
      岡田 洋平
    • Organizer
      第31回徳島県理学療法士学会
    • Related Report
      2020 Research-status Report
    • Invited
  • [Presentation] 適応的な歩行の障害とその神経メカニズム2020

    • Author(s)
      岡田 洋平
    • Organizer
      第18回日本神経理学療法学会学術大会
    • Related Report
      2020 Research-status Report
    • Invited
  • [Presentation] パーキンソン病のリハビリテーションの現状と今後の展望2020

    • Author(s)
      岡田 洋平
    • Organizer
      第9回北海道神経難病リハビリテーション研究会
    • Related Report
      2020 Research-status Report
    • Invited
  • [Presentation] パーキンソン病患者の歩行障害の改善の可能性を高めるための理学療法は?2019

    • Author(s)
      岡田 洋平
    • Organizer
      第2回日本神経理学療法学会SIGs参加型フォーラム シンポジウム
    • Related Report
      2018 Research-status Report
    • Invited
  • [Presentation] 姿勢、歩行制御の障害を理解するための行動および神経生理学的分析2019

    • Author(s)
      岡田 洋平
    • Organizer
      畿央大学ニューロリハビリテーション研究センター シンポジウム企画×プロジェクト研究報告会
    • Related Report
      2018 Research-status Report
  • [Presentation] パーキンソン病の歩行運動制御とリハビリテーション Up To Date2018

    • Author(s)
      岡田 洋平
    • Organizer
      第1回リハビリテーションのための姿勢運動制御研究会
    • Related Report
      2018 Research-status Report
    • Invited
  • [Presentation] パーキンソン病におけるすくみ足に対するリハビリテーション2018

    • Author(s)
      岡田 洋平
    • Organizer
      Japanese Neurologist Parkinson’s Disease Seminar
    • Related Report
      2018 Research-status Report
    • Invited
  • [Presentation] PD 患者における外的キューを用いた系列運動の練習効果 ~ワーキングメモリーの違いが効果に及ぼす影響~2018

    • Author(s)
      成田 雅,岡田 洋平
    • Organizer
      第12回パーキンソン病・運動障害疾患コングレス
    • Related Report
      2018 Research-status Report
  • [Presentation] 神経難病に対する理学療法 ~特にパーキンソン病について~2018

    • Author(s)
      岡田洋平
    • Organizer
      第23回愛媛県理学療法士会学術集会
    • Related Report
      2017 Research-status Report
    • Invited
  • [Presentation] パーキンソン病患者における方向転換動作の特性の解明~Laser計測システムを用いて2017

    • Author(s)
      岡田洋平,萬礼応,福本貴彦,青山朋樹,高橋正樹
    • Organizer
      第11回パーキンソン病・運動障害疾患コングレス
    • Related Report
      2017 Research-status Report
  • [Book] 神経難病リハビリテーション100の叡智2018

    • Author(s)
      岡田 洋平
    • Publisher
      gene-books
    • ISBN
      4905241820
    • Related Report
      2018 Research-status Report
  • [Book] 標準理学療法学 専門分野 神経理学療法学第2版2018

    • Author(s)
      岡田 洋平
    • Publisher
      医学書院
    • ISBN
      4260036211
    • Related Report
      2018 Research-status Report
  • [Book] パーキンソン病の医学的リハビリテーション2018

    • Author(s)
      岡田 洋平
    • Publisher
      日本医事新報社
    • ISBN
      4784948007
    • Related Report
      2018 Research-status Report
  • [Remarks] 畿央大学ニューロリハビリテーション研究センター

    • URL

      https://www.kio.ac.jp/nrc/publication_top/

    • Related Report
      2021 Annual Research Report

URL: 

Published: 2017-04-28   Modified: 2023-01-30  

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