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Autonomous parallel control of breathing and limb movements centered on central chemoreceptors

Research Project

Project/Area Number 17K01612
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Developmental mechanisms and the body works
Research InstitutionHokkaido University

Principal Investigator

Takahiro Yunoki  北海道大学, 教育学研究院, 教授 (00352500)

Project Period (FY) 2017-04-01 – 2022-03-31
Project Status Completed (Fiscal Year 2021)
Budget Amount *help
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2019: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2018: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2017: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Keywords呼吸 / 運動 / 動脈血二酸化炭素分圧 / 中枢化学受容器 / 脊髄運動ニューロン / 身体運動 / 運動生理学 / 呼吸生理学
Outline of Final Research Achievements

Although it is known that a coupling exists between the respiratory control system and the motor control system, the mechanism of this coupling is still unclear. In this study, we examined the effects of inputs to the respiratory control system (manipulation of CO2 and O2 concentrations during inspiration or ventilation volume) on neuromuscular activity in the limbs. The results suggest that an increase in arterial blood CO2 partial pressure may enhance the self-sustained activity of spinal motoneurons innervating the lower leg muscles and that central chemoreceptors may play a certain role there.

Academic Significance and Societal Importance of the Research Achievements

呼吸は四肢の神経筋活動にも影響し、それが呼吸と四肢運動の調節や協調に関係していることが示唆されているが、この呼吸-運動連関のメカニズムは明らかではない。本研究では、動脈血CO2分圧の上昇が、下腿筋を支配する脊髄運動ニューロンの自己持続的活動を増強させている可能性を示した。この増強に関するメカニズムの解明と方法論の確立が進展することで、加齢等による筋力低下や力調整能力の低下への対処、あるいは運動指導やリハビリテーションの実践への貢献が期待される。

Report

(6 results)
  • 2021 Annual Research Report   Final Research Report ( PDF )
  • 2020 Research-status Report
  • 2019 Research-status Report
  • 2018 Research-status Report
  • 2017 Research-status Report
  • Research Products

    (5 results)

All 2022 2021 2019 2018 2017

All Journal Article (2 results) (of which Peer Reviewed: 2 results) Presentation (3 results)

  • [Journal Article] Enhancement of self-sustained muscle activity through external dead space ventilation appears to be associated with hypercapnia2022

    • Author(s)
      Kei Hatano, Ryouta Matsuura, Yoshinori Ohtsuka, Takahiro Yunoki
    • Journal Title

      Respiratory Physiology & Neurobiology

      Volume: 295 Pages: 1-8

    • DOI

      10.1016/j.resp.2021.103777

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Effect of hypercapnia on self-sustained muscle activity2018

    • Author(s)
      Kei Hatano, Kazuki Shirakawa, Noboru Usuda, Ryouta Matsuura, Yoshinori Ohtsuka, Takahiro Yunoki
    • Journal Title

      Respiratory Physiology & Neurobiology

      Volume: 250 Pages: 24-30

    • DOI

      10.1016/j.resp.2018.02.002

    • NAID

      120006633281

    • Related Report
      2017 Research-status Report
    • Peer Reviewed
  • [Presentation] 高二酸化炭素曝露が下腿筋運動ニューロンの興奮性に与える影響2021

    • Author(s)
      波多野慶、河合陽平、柚木孝敬
    • Organizer
      北海道体育学会第60回記念大会
    • Related Report
      2021 Annual Research Report
  • [Presentation] 高炭酸ガス血症が自己持続的ヒラメ筋活動に及ぼす影響2019

    • Author(s)
      波多野慶、大塚吉則、柚木孝敬
    • Organizer
      第13回 motor control 研究会
    • Related Report
      2019 Research-status Report
  • [Presentation] CO2再呼吸が自律持続性筋収縮に及ぼす影響2017

    • Author(s)
      波多野慶、白川和希、臼田昇、松浦亮太、大塚吉則、柚木孝敬
    • Organizer
      第19回日本体力医学会北海道地方会学術集会
    • Related Report
      2017 Research-status Report

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Published: 2017-04-28   Modified: 2023-01-30  

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