| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2019: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2018: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2017: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Outline of Final Research Achievements |
This study tested the hypothesis that nitric oxide (NO) mediates a reduction of resistance exercise blood pressure, a risk factor for future essential hypertension, with aerobic training in older individuals. Older adults participated in a 6-week program as a part of the aerobic training group or the control group. The aerobic exercise intervention increased plasma concentrations of nitrite/nitrate (NOx, end product of NO) and deceased systolic blood pressure (SBP) during resistance exercise and pulse wave velocity (an index of arterial stiffness). Changes in plasma NOx concentrations during the study period were correlated with changes in resistance exercise SBP. Stepwise regression revealed that changes in plasma NOx concentrations during the experimental period are a significant factor of changes in resistance exercise SBP, independent of other variables. These results suggest that NO is associated with decreases in resistance exercise SBP with aerobic training in older individuals.
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