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Effects of voluntary exercise on physiological indices, brain neurotransmitters, and emotional behavior under social isolation stress

Research Project

Project/Area Number 17K01766
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Sports science
Research InstitutionRikkyo University

Principal Investigator

ISHIWATA Takayuki  立教大学, コミュニティ福祉学部, 教授 (40435235)

Project Period (FY) 2017-04-01 – 2021-03-31
Project Status Completed (Fiscal Year 2020)
Budget Amount *help
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2019: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2018: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2017: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
Keywords脳内神経伝達物質 / 生理指標 / 情動行動 / 自発運動 / 社会的隔離 / ストレス / 社会的隔離ストレス / 深部体温 / 活動量
Outline of Final Research Achievements

The purpose of this study was to elucidate the effects of house rearing on physiological indices, brain neurotransmitters, and emotional behavior, and the effects of voluntary exercise on each index, by focusing on the difference in the growth environment (isolation vs. group rearing) related to sociality. Isolation rearing was considered to be more stressful than group rearing, causing an increase in body temperature at rest and changes in the serotonin and noradrenaline in the brain, and also inducing a decrease in sociability. The results of body weight and brain neurotransmitters showed that voluntary exercise in group rearing had a positive effect on physical health, but the results of body temperature and emotional behavior indicated that it may increase mental stress. In the future, it is necessary to consider more appropriate breeding methods that maximize the effects of voluntary exercise.

Academic Significance and Societal Importance of the Research Achievements

本研究において,生育環境の違いによる生理指標,脳内神経伝達物質,情動行動の関係性や,自発運動による各指標への効果の一部を明らかにした.これらの結果は,近年増加傾向にある鬱病をはじめとする精神疾患の原因や発症メカニズムの解明の手掛かりにもなる.今後更に社会性に関連する生育環境の重要性,及び運動の効果を生理神経科学や行動科学の観点から検討し,教育やスポーツの現場に還元することが望まれる.

Report

(5 results)
  • 2020 Annual Research Report   Final Research Report ( PDF )
  • 2019 Research-status Report
  • 2018 Research-status Report
  • 2017 Research-status Report
  • Research Products

    (14 results)

All 2021 2020 2019 2018 2016 Other

All Journal Article (3 results) (of which Peer Reviewed: 3 results) Presentation (7 results) (of which Int'l Joint Research: 4 results,  Invited: 1 results) Remarks (4 results)

  • [Journal Article] Difference in the brain serotonin and its metabolite level and anxiety-like behavior between forced and voluntary exercise conditions in rats2021

    • Author(s)
      Matsunaga Daisuke, Nakagawa Hikaru, Ishiwata Takayuki
    • Journal Title

      Neuroscience Letters

      Volume: 744 Pages: 135556-135556

    • DOI

      10.1016/j.neulet.2020.135556

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Comparison of neurotransmitter levels, physiological conditions, and emotional behavior between isolation‐housed rats with group‐housed rats2020

    • Author(s)
      Kaneda Yuta, Kawata Akira, Suzuki Kota, Matsunaga Daisuke, Yasumatsu Mikinobu, Ishiwata Takayuki
    • Journal Title

      Developmental Psychobiology

      Volume: 63 Issue: 3 Pages: 452-460

    • DOI

      10.1002/dev.22036

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Changes of brain monoamine levels and physiological indexes during heat acclimation in rats2016

    • Author(s)
      Hikaru Nakagawa, Takeru Matsumura, Kota Suzuki, Chisa Ninomiya, Takayuki Ishiwata
    • Journal Title

      Journal of Thermal Biology

      Volume: 58 Pages: 15-22

    • DOI

      10.1016/j.jtherbio.2016.03.010

    • Related Report
      2019 Research-status Report
    • Peer Reviewed
  • [Presentation] Difference in the brain serotonin level and anxiety-like behavior in rats between forced and voluntary exercise conditions.2020

    • Author(s)
      Daisuke Matsunaga, Hikaru Nakagawa, Takayuki Ishiwata
    • Organizer
      Federation of European Neuroscience Societies 2020 Virtual Forum
    • Related Report
      2020 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Changes in brain monoamine levels in the preoptic area and physiological indices in a heat acclimated rat during heat exposure2019

    • Author(s)
      Hikaru Nakagawa, Diasuke Matsunaga, Takayuki Ishiwata
    • Organizer
      14th ICPA2019
    • Related Report
      2019 Research-status Report
    • Int'l Joint Research
  • [Presentation] 自発運動と強制運動の違いがラットの生理指標及び情動行動へ及ぼす影響2019

    • Author(s)
      松長大祐,中川晃,石渡貴之
    • Organizer
      第27回日本運動生理学会大会
    • Related Report
      2019 Research-status Report
  • [Presentation] 環境ストレスが生理指標,脳内神経伝達物質,情動行動に及ぼす影響2018

    • Author(s)
      石渡貴之
    • Organizer
      第73回日本体力医学会
    • Related Report
      2018 Research-status Report
    • Invited
  • [Presentation] 幼若期における社会的隔離がラットの生理指標,脳内神経伝達物質,情動行動に及ぼす影響2018

    • Author(s)
      石渡貴之,金田雄太,川田輝,安松幹展
    • Organizer
      第73回日本体力医学会
    • Related Report
      2018 Research-status Report
  • [Presentation] Forced and voluntary exercise affect brain monoaminergic neurotransmitters and behavior differently in rats.2018

    • Author(s)
      Daisuke Matsunaga, Hikaru Nakagawa, Akira Kawata, Takayuki Ishiwata
    • Organizer
      11th FENS forum of Neuroscience
    • Related Report
      2018 Research-status Report
    • Int'l Joint Research
  • [Presentation] Comparison of physiological indices, emotional behaviors, and monoaminergic neurotransmitters in rat brains in isolation or group-rearing environments2018

    • Author(s)
      Takayuki Ishiwata, Yuta Kaneda, Akira Kawata, Mikinobu Yasumatsu
    • Organizer
      11th FENS forum of Neuroscience
    • Related Report
      2017 Research-status Report
    • Int'l Joint Research
  • [Remarks] Welcome to Ishiwata’s Homepage! 環境生理学研究室

    • URL

      https://sites.google.com/rikkyo.ac.jp/rikkyo-univ-ishiwata-lab/welcome

    • Related Report
      2020 Annual Research Report
  • [Remarks] 研究者情報

    • URL

      https://univdb.rikkyo.ac.jp/view?l=ja&u=1179&n=%E7%9F%B3%E6%B8%A1&sm=name&sl=ja&sp=1

    • Related Report
      2020 Annual Research Report
  • [Remarks] 立教大学 研究者情報

    • URL

      http://univdb.rikkyo.ac.jp/view?l=ja&u=1179&n=%E7%9F%B3%E6%B8%A1&sm=name&sl=ja&sp=1

    • Related Report
      2019 Research-status Report
  • [Remarks] Welcome to Ishiwata’s Homepage! 環境生理学研究室

    • URL

      https://www2.rikkyo.ac.jp/web/ishiwata/Ishiwata_Lab/Welcome.html

    • Related Report
      2019 Research-status Report

URL: 

Published: 2017-04-28   Modified: 2022-01-27  

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