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Risk factors of metabolic syndrome and thinness in young generation and establishment of early intervention

Research Project

Project/Area Number 17K01825
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Applied health science
Research InstitutionChuo University

Principal Investigator

Sata Fumihiro  中央大学, 保健センター, 医療管理者・学校医 (90187154)

Co-Investigator(Kenkyū-buntansha) 小町 裕志  中央大学, 保健センター, 所長 (10796147)
田中 誠一  中央大学, 保健センター, 専任医師 (20796148)
西條 泰明  旭川医科大学, 医学部, 教授 (70360906)
小西 香苗  昭和女子大学, 生活機構研究科, 准教授 (70238103)
Project Period (FY) 2017-04-01 – 2023-03-31
Project Status Completed (Fiscal Year 2022)
Budget Amount *help
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2019: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2018: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2017: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Keywords保健健康管理 / メタボリックシンドローム / やせ / 肥満 / 若年者 / 早期介入
Outline of Final Research Achievements

The objective of this study was to elucidate the risk factors for thinness, obesity, and metabolic syndrome in young generation and to establish early intervention methods for university students and young employees. In 2017, 7,451 students (5,402 men and 2,049 women) and 12,533 employees (6,397 men and 6,136 women) who underwent medical examinations at the University of Tokyo gave consent to participate in this study. Logistic regression analyses were conducted to elucidate the risk factors for thinness, obesity and metabolic syndrome in young generation using data from health examinations and lifestyle questionnaires, and examined effective preventive methods. At the same time, we also summarized the findings on COVID-19 infection control and the DOHaD theory.

Academic Significance and Societal Importance of the Research Achievements

様々の角度から、若年者のやせ、肥満及びメタボリックシンドロームのリスク要因を明らかにし、効果的な予防対策を検討した。若い日本人女性のやせは、低出生体重の原因になると考えられ、将来、成人の低平均身長を引き起こすリスクがあることも報告されている。若年者保健指導法、特に、若い女性のやせ対策は、わが国において喫緊の課題であり、最近、注目されているプレコンセプションケアと相まって社会的意義は大きい。

Report

(7 results)
  • 2022 Annual Research Report   Final Research Report ( PDF )
  • 2021 Research-status Report
  • 2020 Research-status Report
  • 2019 Research-status Report
  • 2018 Research-status Report
  • 2017 Research-status Report
  • Research Products

    (51 results)

All 2023 2022 2021 2020 2019 2018 2017 Other

All Journal Article (28 results) (of which Int'l Joint Research: 3 results,  Peer Reviewed: 19 results,  Open Access: 11 results) Presentation (20 results) (of which Int'l Joint Research: 5 results,  Invited: 4 results) Book (2 results) Remarks (1 results)

  • [Journal Article] Association Between Smoking and Hypertension in Pregnancy Among Japanese Women: A Meta-analysis of Birth Cohort Studies in the Japan Birth Cohort Consortium (JBiCC) and JECS2023

    • Author(s)
      Morisaki N, Obara T, Piedvache A, Kobayashi S, Miyashita C, Nishimura T, Ishikuro M, Sata F, Horikawa R, Mori C, Metoki H, Tsuchiya KJ, Kuriyama S, Kishi R.
    • Journal Title

      Journal of Epidemiology

      Volume: 33 Issue: 10 Pages: 498-507

    • DOI

      10.2188/jea.JE20220076

    • ISSN
      0917-5040, 1349-9092
    • Year and Date
      2023-10-05
    • Related Report
      2022 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] DOHaDとの出会いと10年間の歩み2023

    • Author(s)
      佐田 文宏.
    • Journal Title

      Developmental Origins of Health and Disease Research

      Volume: 11 Issue: 1 Pages: 17-19

    • DOI

      10.51067/dohad.11.1_17

    • ISSN
      2187-2562, 2187-2597
    • Related Report
      2022 Annual Research Report
    • Open Access
  • [Journal Article] 低出生体重児減少のための予防的アクション2023

    • Author(s)
      小西 香苗.
    • Journal Title

      Developmental Origins of Health and Disease Research

      Volume: 11 Issue: 1 Pages: 11-13

    • DOI

      10.51067/dohad.11.1_11

    • ISSN
      2187-2562, 2187-2597
    • Related Report
      2022 Annual Research Report
    • Open Access
  • [Journal Article] Gene-environment interactions related to maternal exposure to environmental and lifestyle-related chemicals during pregnancy and the resulting adverse fetal growth: a review2022

    • Author(s)
      Kobayashi S, Sata F, Kishi R.
    • Journal Title

      Environmental Health and Preventive Medicine

      Volume: 27 Issue: 0 Pages: 24-24

    • DOI

      10.1265/ehpm.21-00033

    • ISSN
      1342-078X, 1347-4715
    • Related Report
      2022 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Association of exposure to prenatal per?uoroalkyl substances and estrogen receptor 1 polymorphisms with the second to fourth digit ratio in school-aged children: The Hokkaido study2022

    • Author(s)
      Nishimura Yoko、Moriya Kimihiko、Kobayashi Sumitaka、Ikeda- Araki Atsuko、Sata Fumihiro、Mitsui Takahiko、Itoh Sachiko、Miyashita Chihiro、Cho Kazutoshi、Kon Masafumi、Nakamura Michiko、Kitta Takeya、Murai Sachiyo、Kishi Reiko、Shinohara Nobuo
    • Journal Title

      Reproductive Toxicology

      Volume: 109 Pages: 10-18

    • DOI

      10.1016/j.reprotox.2022.02.002

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Relationships between maternal perfluoroalkyl substance levels, polymorphisms of receptor genes, and adverse birth outcomes in the Hokkaido birth cohort study, Japan2022

    • Author(s)
      Kobayashi Sumitaka、Sata Fumihiro、Ikeda-Araki Atsuko、Miyashita Chihiro、Goudarzi Houman、Iwasaki Yusuke、Nakajima Tamie、Kishi Reiko
    • Journal Title

      Reproductive Toxicology

      Volume: 107 Pages: 112-122

    • DOI

      10.1016/j.reprotox.2021.12.004

    • Related Report
      2021 Research-status Report
    • Peer Reviewed
  • [Journal Article] Associations between maternal mono-(2-ethylhexyl) phthalate levels, nuclear receptor gene polymorphisms, and fatty acid levels in pregnant Japanese women in the Hokkaido study2022

    • Author(s)
      Kobayashi Sumitaka、Sata Fumihiro、Miyashita Chihiro、Ikeda-Araki Atsuko、Goudarzi Houman、Nakajima Tamie、Kishi Reiko
    • Journal Title

      Reproductive Toxicology

      Volume: 107 Pages: 22-32

    • DOI

      10.1016/j.reprotox.2021.11.003

    • Related Report
      2021 Research-status Report
    • Peer Reviewed
  • [Journal Article] 大学教職員のやせに影響を及ぼす要因の検討.2022

    • Author(s)
      佐田文宏,西條泰明,小西香苗,田中誠一,柳元伸太郎.
    • Journal Title

      Campus Health

      Volume: 59 Pages: 71-73

    • Related Report
      2021 Research-status Report
  • [Journal Article] Haemodynamic benefit of bridging use of bosentan prior to pulmonary endarterectomy.2021

    • Author(s)
      Kunihara T, Wilkens H, Halank M, Held M, Nomura R, Igarashi T, Sata F, Schテ、fers HJ.
    • Journal Title

      European Journal of Cardio-Thoracic Surgery

      Volume: 60 Issue: 4 Pages: 840-847

    • DOI

      10.1093/ejcts/ezab137

    • Related Report
      2021 Research-status Report 2020 Research-status Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Associations among maternal perfluoroalkyl substance levels, fetal sex-hormone enzymatic gene polymorphisms, and fetal sex hormone levels in the Hokkaido study2021

    • Author(s)
      Kobayashi Sumitaka、Sata Fumihiro、Ikeda-Araki Atsuko、Miyashita Chihiro、Itoh Sachiko、Goudarzi Houman、Iwasaki Yusuke、Mitsui Takahiko、Moriya Kimihiko、Shinohara Nobuo、Cho Kazutoshi、Kishi Reiko
    • Journal Title

      Reproductive Toxicology

      Volume: 105 Pages: 221-231

    • DOI

      10.1016/j.reprotox.2021.09.003

    • Related Report
      2021 Research-status Report
    • Peer Reviewed
  • [Journal Article] Surgical Thoracoabdominal Aortic Aneurysm Repair in a Non-High-Volume Institution.2021

    • Author(s)
      Kunihara T, Vukic C, Sata F, Schテ、fers HJ.
    • Journal Title

      The Thoracic and Cardiovascular Surgeon

      Volume: 69 Issue: 04 Pages: 347-356

    • DOI

      10.1055/s-0040-1708470

    • Related Report
      2021 Research-status Report 2020 Research-status Report 2019 Research-status Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Associations among perfluorooctanesulfonic/perfluorooctanoic acid levels, nuclear receptor gene polymorphisms, and lipid levels in pregnant women in the Hokkaido study2021

    • Author(s)
      Kobayashi Sumitaka、Sata Fumihiro、Goudarzi Houman、Araki Atsuko、Miyashita Chihiro、Sasaki Seiko、Okada Emiko、Iwasaki Yusuke、Nakajima Tamie、Kishi Reiko
    • Journal Title

      Scientific Reports

      Volume: 11 Issue: 1 Pages: 9994-9994

    • DOI

      10.1038/s41598-021-89285-2

    • Related Report
      2021 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] 大学における新型コロナウイルス感染防止対策に関する実態調査.2021

    • Author(s)
      佐田文宏,柳元伸太郎.
    • Journal Title

      Campus Health

      Volume: 58 Pages: 97-101

    • Related Report
      2021 Research-status Report 2020 Research-status Report
  • [Journal Article] Association of exposure to prenatal phthalate esters and bisphenol A and polymorphisms in the ESR1 gene with the second to fourth digit ratio in school-aged children: Data from the Hokkaido study2020

    • Author(s)
      Nishimura Yoko、Moriya Kimihiko、Kobayashi Sumitaka、Araki Atsuko、Sata Fumihiro、Mitsui Takahiko、Itoh Sachiko、Miyashita Chihiro、Cho Kazutoshi、Kon Masafumi、Nakamura Michiko、Kitta Takeya、Murai Sachiyo、Kishi Reiko、Shinohara Nobuo
    • Journal Title

      Steroids

      Volume: 159 Pages: 108637-108637

    • DOI

      10.1016/j.steroids.2020.108637

    • Related Report
      2020 Research-status Report 2019 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] DOHaD学説:その成り立ちと学術分野としての発展.2020

    • Author(s)
      佐田文宏.
    • Journal Title

      医学のあゆみ

      Volume: 275 Pages: 939-946

    • Related Report
      2020 Research-status Report
  • [Journal Article] Gene-Environment Interactions to Detect Adverse Health Effects on the Next Generation.2019

    • Author(s)
      Sata F, Kobayashi S, Kishi R.
    • Journal Title

      Current Topics in Environmental Health and Preventive Medicine

      Volume: 13 Pages: 485-512

    • DOI

      10.1007/978-981-15-0520-1_19

    • ISBN
      9789811505195, 9789811505201
    • Related Report
      2019 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Cryptorchidism and Hypospadias.2019

    • Author(s)
      Mitsui T, Sata F, Kishi R.
    • Journal Title

      Current Topics in Environmental Health and Preventive Medicine

      Volume: 13 Pages: 69-99

    • DOI

      10.1007/978-981-15-0520-1_4

    • ISBN
      9789811505195, 9789811505201
    • Related Report
      2019 Research-status Report
    • Peer Reviewed
  • [Journal Article] Dose-dependent associations between prenatal caffeine consumption and small for gestational age, preterm birth, and reduced birthweight in the Japan Environment and Children's Study.2019

    • Author(s)
      Kobayashi S, Sata F, Murata K, Saijo Y, Araki A, Miyashita C, Itoh S, Minatoya M, Yamazaki K, Ait Bamai Y, Kishi R; Japan Environment and Children's Study Group.
    • Journal Title

      Paediatric and Perinatal Epidemiology

      Volume: 33 Issue: 3 Pages: 185-194

    • DOI

      10.1111/ppe.12551

    • NAID

      120006842195

    • Related Report
      2019 Research-status Report 2018 Research-status Report
    • Peer Reviewed
  • [Journal Article] Association between maternal passive smoking and increased risk of delivering small-for-gestational-age infants at full-term using plasma cotinine levels from The Hokkaido Study: a prospective birth cohort.2019

    • Author(s)
      Kobayashi S, Sata F, Hanaoka T, Braimoh TS, Ito K, Tamura N, Araki A, Itoh S, Miyashita C, Kishi R.
    • Journal Title

      BMJ Open

      Volume: 9(2) Issue: 2 Pages: e023200-e023200

    • DOI

      10.1136/bmjopen-2018-023200

    • NAID

      120006552871

    • Related Report
      2018 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Association between ESR1 polymorphisms and second to fourth digit ratio in school-aged children in the Hokkaido Study.2019

    • Author(s)
      Nishimura Y, Moriya K, Kobayashi S, Araki A, Sata F, Mitsui T, Itoh S, Miyashita C, Cho K, Kon M, Nakamura M, Kitta T, Murai S, Kishi R, Shinohara N.
    • Journal Title

      Steroids

      Volume: 141 Pages: 55-62

    • DOI

      10.1016/j.steroids.2018.11.011

    • Related Report
      2018 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Relationships between Alcohol Intake and Ischemic Stroke Severity in Sex Stratified Analysis for Japanese Acute Stroke Patients.2019

    • Author(s)
      Shiotsuki H, Saijo Y, Ogushi Y, Kobayashi S; Japan Standard Stroke Registry Study Group.
    • Journal Title

      Journal of Stroke & Cerebrovascular Diseases

      Volume: 28 Issue: 6 Pages: 1604-1617

    • DOI

      10.1016/j.jstrokecerebrovasdis.2019.02.034

    • Related Report
      2018 Research-status Report
    • Peer Reviewed
  • [Journal Article] Job Stress Factors Affect Workplace Resignation and Burnout among Japanese Rural Physicians2018

    • Author(s)
      Saijo Y, Yoshioka E, Hanley SJB, Kitaoka K, Yoshida T.
    • Journal Title

      The Tohoku Journal of Experimental Medicine

      Volume: 245 Issue: 3 Pages: 167-177

    • DOI

      10.1620/tjem.245.167

    • NAID

      130007403958

    • ISSN
      0040-8727, 1349-3329
    • Related Report
      2018 Research-status Report
    • Peer Reviewed
  • [Journal Article] DOHaDの疫学 出生コホート研究2018

    • Author(s)
      佐田 文宏
    • Journal Title

      小児科診療

      Volume: 81 Pages: 1307-1315

    • Related Report
      2018 Research-status Report
  • [Journal Article] DOHaD研究の現況と今後の課題2018

    • Author(s)
      佐田 文宏
    • Journal Title

      東京小児科医会報

      Volume: 37 Pages: 63-68

    • Related Report
      2018 Research-status Report
  • [Journal Article] 出生コホート研究.2018

    • Author(s)
      佐田文宏.
    • Journal Title

      小児科診療

      Volume: 81

    • Related Report
      2017 Research-status Report
  • [Journal Article] Effects of low-level prenatal exposure to dioxins on cognitive development in Japanese children at 42 months2018

    • Author(s)
      Ikeno Tamiko、Miyashita Chihiro、Nakajima Sonomi、Kobayashi Sumitaka、Yamazaki Keiko、Saijo Yasuaki、Kita Toshiko、Sasaki Seiko、Konishi Kanae、Kajiwara Junboku、Hori Tsuguhide、Kishi Reiko
    • Journal Title

      Science of The Total Environment

      Volume: 618 Pages: 1423-1430

    • DOI

      10.1016/j.scitotenv.2017.09.267

    • NAID

      120006812530

    • Related Report
      2017 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] 医師の立場から見たタバコ.2017

    • Author(s)
      小町裕志.
    • Journal Title

      中央評論

      Volume: 300 Pages: 148-156

    • Related Report
      2017 Research-status Report
  • [Journal Article] Social support and its interrelationships with demand?control model factors on presenteeism and absenteeism in Japanese civil servants2017

    • Author(s)
      Saijo Yasuaki、Yoshioka Eiji、Nakagi Yoshihiko、Kawanishi Yasuyuki、Hanley Sharon J. B.、Yoshida Takahiko
    • Journal Title

      International Archives of Occupational and Environmental Health

      Volume: 90 Issue: 6 Pages: 539-553

    • DOI

      10.1007/s00420-017-1218-y

    • Related Report
      2017 Research-status Report
    • Peer Reviewed
  • [Presentation] わが国のDOHaD研究の歩み.2023

    • Author(s)
      佐田 文宏.
    • Organizer
      第93回日本衛生学会学術総会
    • Related Report
      2022 Annual Research Report
  • [Presentation] Establishment and management of a collaborative platform of birth cohorts in Japan.2022

    • Author(s)
      Sata F, Morisaki N, Shimizu A, Obara T, Metoki H, Tsuchiya KJ, Horikawa R, Mori C, Kishi R, Kuriyama S.
    • Organizer
      12th World Congress on Developmental Origins of Health and Disease
    • Related Report
      2022 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Relationship between iron supplementation during pregnancy and pre-pregnancy body mass index.2022

    • Author(s)
      Konishi K.
    • Organizer
      12th World Congress on Developmental Origins of Health and Disease
    • Related Report
      2022 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Dietary habits and metabolic syndrome among Japanese employees.2022

    • Author(s)
      Konishi K, Nakagawa K, Mihara S, Saijo Y, Yanagimoto S, Sata F.
    • Organizer
      22nd IUNS-ICN International Congress of Nutrition
    • Related Report
      2022 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 女子大学生の貧血に影響を及ぼす要因の検討.2022

    • Author(s)
      小西 香苗, 西條 泰明, 柳元 伸太郎, 佐田 文宏.
    • Organizer
      第76回日本栄養・食糧学会大会
    • Related Report
      2022 Annual Research Report
  • [Presentation] 若年成人女性における体組成と出生体重との関連.2022

    • Author(s)
      倉田 幸奈, 小西 香苗.
    • Organizer
      第9回日本DOHaD学会学術集会
    • Related Report
      2022 Annual Research Report
  • [Presentation] 国内出生コホート連携基盤の構築・維持・更新:日本の出生コホートの取り組み.2022

    • Author(s)
      佐田文宏.
    • Organizer
      第92回日本衛生学会学術総会
    • Related Report
      2021 Research-status Report
  • [Presentation] 妊娠中の環境化学物質曝露と胎児発育:遺伝環境交互作用に関する疫学研究文献レビュー.2022

    • Author(s)
      小林澄貴,佐田文宏,岸 玲子.
    • Organizer
      第92回日本衛生学会学術総会
    • Related Report
      2021 Research-status Report
  • [Presentation] Combined effects of sex hormone levels and genetic polymorphisms on digit ratio in school-aged children.2021

    • Author(s)
      Sata F, Mitsui T, Araki A, Miyashita C, Ito S, Sasaki S, Kitta T, Moriya K, Kish R, Nonomura K.
    • Organizer
      World Congress of Epidemology (WCE 2021)
    • Related Report
      2021 Research-status Report
    • Int'l Joint Research
  • [Presentation] 大学教職員のやせに影響を及ぼす要因の検討.2021

    • Author(s)
      佐田文宏,西條泰明,小西香苗,田中誠一,柳元伸太郎.
    • Organizer
      第59回全国大学保健管理研究集会
    • Related Report
      2021 Research-status Report
  • [Presentation] 若年者のやせに影響を及ぼす要因の検討.2021

    • Author(s)
      佐田文宏,西條泰明,小西香苗,田中誠一,小町裕志,柳元伸太郎.
    • Organizer
      第91回日本衛生学会学術総会
    • Related Report
      2020 Research-status Report
  • [Presentation] 大学における新型コロナウイルス感染防止対策に関する実態調査.2020

    • Author(s)
      佐田文宏,柳元伸太郎.
    • Organizer
      第58回全国大学保健管理研究集会
    • Related Report
      2020 Research-status Report
  • [Presentation] An attempt of holding a workshop of birth cohort collaboration toward establishing consortia in Japan.2019

    • Author(s)
      Sata F.
    • Organizer
      11th World Congress on Developmental Origins of Health and Disease.
    • Related Report
      2019 Research-status Report
    • Int'l Joint Research
  • [Presentation] 第1回出生コホート研究連携ワークショップ~コンソーシアム設立に向けた試み~.2019

    • Author(s)
      佐田 文宏.
    • Organizer
      第8回日本DOHaD学会学術集会
    • Related Report
      2019 Research-status Report
    • Invited
  • [Presentation] 胎児期有機フッ素化合物濃度と出生体重との関連:異物代謝酵素遺伝型の修飾による影響-北海道スタディ2019

    • Author(s)
      小林澄貴、佐田文宏、荒木敦子、宮下ちひろ、佐々木成子、坂 晋、岩崎雄介、岸 玲子
    • Organizer
      第29回日本疫学会学術総会
    • Related Report
      2018 Research-status Report
  • [Presentation] わが国におけるDOHaD関連政策提言の歩みと今後の期待.2018

    • Author(s)
      佐田文宏.
    • Organizer
      第88回日本衛生学会学術総会
    • Related Report
      2017 Research-status Report
  • [Presentation] 最近の出生コホート研究とDOHaD関連政策提言の歩み.2017

    • Author(s)
      佐田文宏.
    • Organizer
      第14回健康価値創造研究会
    • Related Report
      2017 Research-status Report
    • Invited
  • [Presentation] 世界と日本の出生コホート研究.2017

    • Author(s)
      佐田文宏.
    • Organizer
      第6回日本DOHaD学会学術集会
    • Related Report
      2017 Research-status Report
    • Invited
  • [Presentation] DOHaD説に基づく先制医療とライフコース・ヘルスケア.2017

    • Author(s)
      佐田文宏.
    • Organizer
      内科懇話会.
    • Related Report
      2017 Research-status Report
    • Invited
  • [Presentation] 出生ゲノムコホート研究の現状と課題.2017

    • Author(s)
      佐田文宏.
    • Organizer
      第2回DOHaD疫学セミナー例会.
    • Related Report
      2017 Research-status Report
  • [Book] DOHaD 先制医療への展開2023

    • Author(s)
      一般社団法人日本DOHaD学会
    • Total Pages
      316
    • Publisher
      金原出版
    • ISBN
      9784307170796
    • Related Report
      2022 Annual Research Report
  • [Book] Pre-emptive Medicine: Public Health Aspects of Developmental Origins of Health and Disease2019

    • Author(s)
      Fumihiro Sata, Hideoki Fukuoka, Mark Hanson
    • Total Pages
      217
    • Publisher
      Springer Nature
    • ISBN
      9789811321931
    • Related Report
      2018 Research-status Report
  • [Remarks] DOHaD疫学セミナー

    • URL

      http://dohadepi.kenkyuukai.jp/

    • Related Report
      2019 Research-status Report

URL: 

Published: 2017-04-28   Modified: 2024-01-30  

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