| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2019: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2018: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2017: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
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| Outline of Final Research Achievements |
The increase in the number of elderly people and the increase in the number of patients with dementia has become a social problem in Japan. Nrf2 induces the expression of antioxidant enzyme genes in response to oxidative stress and suppresses the expression of inflammatory cytokine genes. Genetic Nrf2 induction model mice were crossed with Alzheimer's disease model to generate double mutant Nrf2 induced Alzheimer's disease model mice. Nrf2 induction in the brain of Alzheimer's disease model mice increased glutathione synthesis, and suppresses the induction of disease-associated microglia observed in the brains of Alzheimer's disease model mice, resulting in suppression of neuropathy around amyloid plaques.
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